Clinical trials: Emergency Departments
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Pain
Comparison of Lidocaine-Prilocaine Combination and Vapocoolant for IV Cannulation Pain in the ED
Hypothesis: Lidocaine-Prilocaine Combination is as effective as Vapocoolant in treating IV cannulation pain in the emergency department.
- Trial name
- NCT04473820
- Testing
- Vapocoolant spray, Lidocaine-Prilocaine cream
- Where
- Iran
- Volunteers
- 77 people
- Sponsor
- Tehran University of Medical Sciences
Physiological Stress, Psychological Stress
Descriptive Study of Biological Stress and Perceived Stress at the Center 15
The purpose of this study is to describe biological stress (cortisolemia) and perceived stress in Emergency Call Center Operators and Doctors while processing a center 15 call.
- Trial name
- RegulStress (NCT02075424)
- Testing
- salivary sampling by a biomnis swab
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Sickle Cell Disease
Improving Emergency Department Management of Adults With Sickle Cell Disease
The objective of this study is to design, implement and test quality improvement measures to improve the care of adults with sickle cell disease in the emergency department.
- Trial name
- NCT01603160
- Testing
- Quality Improvement
- Where
- United States
- Volunteers
- 715 people
- Sponsor
- Duke University
Acute Myocardial Infarction, Acute Coronary Syndrome
Use of High Sensitivity Cardiac Troponin In Ruling Out Emergency Patients With Acute Myocardial Injury and Infarction
Examine the analytical and clinical performance of Atellica IM TnIH assay for the diagnosis and rule out of acute myocardial injury and myocardial infarction in patients presenting to the emergency department in whom serial cTnI…
- Trial name
- SAFETY (NCT04280926)
- Testing
- Cardiac Troponin Testing
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Fred Apple
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
IMproved PREdiction of Severe Sepsis in the Emergency Department
The purposes of this study is to determine whether Heparin Binding Protein (HBP) can be used as a marker of severe sepsis (including septic shock) in patients presenting to the emergency department with suspected infection.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Sepsis, Severe Sepsis, Septic Shock
- Trial name
- IMPRESSED (NCT01392508)
- Where
- 5 sites in United States, Sweden
- Volunteers
- 759 people
- Sponsor
- Axis Shield Diagnostics Ltd
Sepsis, Infection
Heparin Binding Protein in Early Sepsis Diagnosis
The primary objective of this study is to use heparin-binding protein (HBP) concentration to indicate the presence, or outcome, of sepsis over 72 hours after ED admission.
- Trial name
- PROMPT (NCT03295825)
- Testing
- Biomarker
- Where
- 6 sites in Greece
- Volunteers
- 400 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Neck Pain, Ankle Injuries
Acupuncture for Pain Control in the Emergency Department
Acupuncture is widely used for managing acute and chronic pain conditions. In the context of an emergency department (ED), patients often present with non-emergent acute pain symptoms.
- Conditions
- Neck Pain, Ankle Injuries, Headache Disorders, Primary
- Trial name
- NCT02013908
- Testing
- Acupuncture plus standard ED management, Standard ED management alone
- Where
- South Korea
- Volunteers
- 17 people
- Sponsor
- Korean Medicine Hospital of Pusan National University
Triage, Pediatrics
The Canadian Triage and Acuity Scale for Children; A Prospective Multi-Center Evaluation.
The aim of this study is to evaluate the validity and the reproducibility of the canadian triage and acuity scale when applied by regular nurses for the triage of children in the Emergency Department.
- Trial name
- PERC CTAS (NCT00807352)
- Where
- 9 sites in Canada
- Volunteers
- 1,464 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Critical Illness, Emergency Department Patient
Critical Care Admission Following Emergency Department's Resuscitation Room Care
This prospective multicenter observational study aims to describe resuscitation room activity in France and to compare critical care admission within 24 hours between patients directly admitted to the resuscitation room and those…
- Conditions
- Critical Illness, Emergency Department Patient, Shock, Trauma (Including Fractures)
- Trial name
- SAUV-IRU (NCT07411976)
- Testing
- Emergency resuscitation room management (observational)
- Where
- France
- Volunteers
- 1,629 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Mental Health Issue
The Benefits of Telephone Follow-up (TFU)
This study will investigate the impact of a brief telephone follow-up following a mental health assessment in the emergency department.
- Trial name
- TFU (NCT04793282)
- Testing
- Telephone Follow-up
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brandon University
Bronchial Asthma
Assessment of Asthma Exacerbation in Children by Modified Pulmonary Index Score
Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness and cough that vary over time and…
- Trial name
- NCT03190759
- Volunteers
- 1 people
- Sponsor
- Assiut University
Medical Education
Online Ultrasound Curriculum on Learning Outcomes of Post-graduate Physicians
This single-center retrospective study evaluates the effectiveness of the Training Management System (TMS) ultrasound curriculum on the learning outcomes of PGY emergency physicians.
- Trial name
- NCT06950346
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Non-specific Low Back Pain
Adjunctive Wet Cupping for Acute Non-Specific Low Back Pain
This prospective randomized controlled trial evaluated the effectiveness and safety of adjunctive wet cupping therapy combined with standard pharmacological treatment in adults presenting to the emergency department with acute…
- Trial name
- NCT07837596
- Testing
- Wet Cupping Therapy, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ataturk University
Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay
Prophylactic Negative Wound Therapy in Laparotomy Wounds.
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. The impact of different types of wound therapy are not clear in the literature.
- Trial name
- PROPEL (NCT03871023)
- Testing
- Smith & Nephew PICO Negative wound pressure versus standard dresing, PREVENA Negative pressure wound versus standard dressing
- Where
- Ireland
- Volunteers
- 240 people
- Sponsor
- St. James's Hospital, Ireland
Bleeding Ugi
PillSense for Suspected Upper Gastrointestinal Bleeding
This study aims to evaluate the efficacy and safety of a novel blood sensing capsule (PillSense), to help emergency doctors better evaluate if patients have active upper digestive tract bleeding, to determine if they can be…
- Trial name
- BLEED (NCT06500468)
- Testing
- PillSense System
- Where
- Singapore
- Volunteers
- 84 people
- Sponsor
- Tan Tock Seng Hospital
Patient Satisfaction
The Influence of Expectations on Patient Satisfaction in the Pediatric Emergency Department
The purpose of this study is to determine whether physician knowledge of parental pre-visit expectations improves patient satisfaction in the pediatric emergency department.
- Trial name
- NCT00293982
- Testing
- Physician knowledge of parental expectations for the visit
- Where
- United States
- Volunteers
- 948 people
- Sponsor
- Medical College of Wisconsin
Emergency Department, Crowding
A New Crowding Indicator in the Emergency Department
Fenice has proposed a new indicator to measure the level of crowding in the ER. The aim of this study is to evaluate, in a national multicenter context, the degree of agreement between the Fenice indicator and the perception of…
- Trial name
- NCT07111624
- Where
- 52 sites in Italy
- Volunteers
- 828 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Hypotension
Efficacy Study of a Facemask Device to Treat Hypotension
The purpose of this study is to determine if the impedance threshold device (ITD) attached to a facemask can increase blood pressure in patients who present to the emergency department with hypotension secondary to hypovolemia.
- Trial name
- NCT00256724
- Testing
- Impedance Threshold Device
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Advanced Circulatory Systems
Opioid Use
Incentivizing Buprenorphine-Naloxone Initiation in Emergency Departments
This study seeks to test standard and behavioral economic-enhanced training strategies to bolster first-time Emergency Department-initiated buprenorphine-naloxone administration among Emergency Department providers.
- Trial name
- NCT03821103
- Testing
- Training, Behavioral economic enhanced arm
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Pennsylvania
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