Clinical trials: Emergency General Surgery
Postoperative Morbidity, Postoperative Mortality
Fluid Loading in Abdominal Surgery: Saline Versus Hydroxyethyl Starch (FLASH Study)
The primary purpose of the study is to evaluate whether the type of fluid (0.9% saline or 6% Hydroxyethyl starch 130/0.4) in the context of an individualized goal-directed fluid therapy is associated with a difference in…
- Trial name
- FLASH (NCT02502773)
- Testing
- Hydroxethyl starch
- Where
- France
- Volunteers
- 826 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgery, Emergencies
Laparoscopic Versus Open Repair of Peptic Ulcer Perforation
Although laparoscopic repair (LR) of perforated peptic ulcers (PPUs) has long been accepted, clinical evidence comparing LR versus open repair (OR) remains lacking.
- Conditions
- Surgery, Emergencies, Peptic Ulcer Perforation
- Trial name
- LOREPUP (NCT04447170)
- Testing
- Simple repair or Graham technique
- Where
- 13 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Gianluca Costa
Acute Cholecystitis, Biliary Complications
Acute Cholecystitis Biliary Complications - ICG
Acute cholecystitis is a common indication for emergency laparoscopic cholecystectomy. Inflammatory changes and distorted anatomy may increase the risk of biliary complications, including bile duct injury and bile leak, which are…
- Trial name
- ICG-ACBC (NCT07481760)
- Testing
- ICG
- Where
- Spain
- Volunteers
- 296 people
- Sponsor
- Hospital del Mar
Severe Sepsis, Emergency
Impact of Early Goal-directed Fluid Therapy in Septic Patients Undergoing Emergency Surgery
This study wants to compared the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in septic patients requiring emergency surgery.
- Conditions
- Severe Sepsis, Emergency, Surgery
- Trial name
- NCT01654003
- Testing
- CONTROL, OPTIMIZED
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Geneva
Colorectal Cancer
Emergency Surgery Versus Colorectal Stents for the Management of Malignant Colonic Obstructions
The study evaluates and compares effect of emergency surgery and colonic stents for treatment of malignant colonic obstructions.
- Trial name
- NCT04449822
- Testing
- Emergency surgery, Colonic stenting
- Where
- Georgia
- Volunteers
- 40 people
- Sponsor
- Zaza Demetrashvili
Acute Appendicitis, Acute Appendicitis With Rupture
Modified Enhanced Recovery Program in Emergency Surgery (MERES)
Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis With Peritonitis, Acute Appendicitis Without Peritonitis
- Trial name
- MERES (NCT03754777)
- Testing
- Laparoscopic appendectomy
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Pirogov Russian National Research Medical University
Pain, Postoperative, Abdominal Surgery
Erector Spinae Plane Block Versus Oblique-Subcostal Transversus Abdominis Plane Block in Emergency Abdominal Surgery with Midline Incision
Most of the recommendations regarding pain management in emergency abdominal surgery are extracted from data from elective abdominal surgery.
- Conditions
- Pain, Postoperative, Abdominal Surgery, Emergency
- Trial name
- NCT06448299
- Testing
- TAPB, ESPB
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Kasr El Aini Hospital
Emergency Surgery, Full Stomach
Assessment of Prokinetic Effects of Erythromycin in Emergency Patients With a Full Stomach
The aims of the study is to assess whether the intravenous infusion of 3 mg/kg erythromycin has a significant gastrokinetic effect leading to empty the stomach in less than 90 minutes in non-fasting patients undergoing emergency…
- Trial name
- NCT02296866
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Lionel Bouvet
Surgery--Complications, Abdomen Disease
Use of Wearables for Early Detection of Complications After Major Acute Abdominal Surgery
The purpose of the study is to investigate whether glucose profile, sleep disturbances and heart rate variability measured with wearable devices is associated with postoperative recovery and complications within 30 days after…
- Trial name
- NCT04257344
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Mortality, Pediatric
Operative Duration as a Predictor of Mortality in Pediatric Emergency Surgery
Introduction Operative duration is an important but under-studied predictor of mortality in emergency laparotomies. Aims \& Objectives The objective of this study was to quantify the effect of duration of emergency laparotomy in…
- Conditions
- Mortality, Pediatric, Laparotomy, Emergencies
- Trial name
- NCT03270930
- Testing
- Emergency laparotomy
- Volunteers
- 213 people
- Sponsor
- Jawaharlal Nehru Medical College
Educational Problems, Orthopedic Disorder
Assessment of an Orthopedic Surgery Rotation on Musculoskeletal Competency in Emergency Medicine Residency Training
Patient commonly present with orthopedic injuries in the emergency department. Musculoskeletal education has not historically been emphasized in American medical schools, and the effectiveness of an orthopedic surgery rotation…
- Conditions
- Educational Problems, Orthopedic Disorder, Emergencies
- Trial name
- NCT03944746
- Testing
- Education Curriculum
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Jared L. Cohen
Emergency Surgery
Preoperative Rapid Pou Ultrasound Assessment in Critically Ill Patients Undergoing Emergency Surgery
With the development of society, the number of emergency critical operations is increasing year by year. Traditionally, the patient's systemic and circulatory status is indirectly assessed by testing and blood pressure heart…
- Trial name
- NCT04111783
- Testing
- POU protocol ultrasound
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shenzhen People's Hospital
Laparotomy, Dehiscence Wound
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory…
- Conditions
- Laparotomy, Dehiscence Wound, Surgical Site Infections, Trauma Abdomen
- Trial name
- NCT06043414
- Testing
- triclosan-coated barbed suture, triclosan-coated non-barbed suture, Non-coated non-barbed suture
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Southern California
Hernia, Emergencies
Management of Acutely Symptomatic Hernia
Acutely symptomatic abdominal wall hernia can cause many symptoms and complications. They can be associated with levels of morbidity beyond that seen in emergency laparotomy. There is limited data to guide practice in this field.
- Conditions
- Hernia, Emergencies, Surgery--Complications
- Trial name
- MASH (NCT04197271)
- Testing
- Emergency Hernia Repair, Conservative management
- Where
- United Kingdom
- Volunteers
- 280 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Colon Perforation
Feasibility and Effects of an Enhanced Recovery vs Conventional Care After Emergency Colon Surgery for Patients With Left Colon Perforation.
A study was designed with a prospective cohort of all patients undergoing urgent surgery for left colon perforation between March 2014 and June 2017 who were treated according to a specific ERAS programme (ERAS group/29…
- Trial name
- NCT03611413
- Testing
- ERAS care
- Volunteers
- 50 people
- Sponsor
- Antonio Arroyo Sebastian
Surgical Incision, Wound Dehiscence
Treating Emergency Laparotomy Incisions With Negative Pressure Wound Therapy
The goal of this clinical trial is to investigate Negative Pressure Wound Therapy (NPWT) in adults undergoing emergency laparotomy.
- Conditions
- Surgical Incision, Wound Dehiscence, Surgical Site Infection, Incisional Hernia
- Trial name
- TELIN (NCT07003906)
- Testing
- Negative pressure wound therapy, Standard postoperative dressing
- Where
- 6 sites in Sweden
- Volunteers
- 720 people
- Sponsor
- Uppsala University
Emergency Laparotomy, Quality Improvement
Quality Improvement Audit of ERAS Protocol Adherence in Emergency Laparotomy
This study evaluates the implementation of Enhanced Recovery After Surgery (ERAS) protocols during emergency laparotomy procedures in a resource-limited hospital in Sudan.
- Conditions
- Emergency Laparotomy, Quality Improvement, Implementation Science, Enhanced Recovery After Surgery (ERAS) Protocol
- Trial name
- NCT06757127
- Testing
- ERAS Protocol Adaptation for Emergency Laparotomy
- Where
- Sudan
- Volunteers
- 40 people
- Sponsor
- Sudan Medical Specialization Board
Surgery
Evaluation of the Use of the RELAX® Glasses on the Anxiety of Patients Undergoing Emergency Hand Surgery Under Locoregional Anesthesia
More than 90% of hand surgery is performed under local anesthesia and can be a source of anxiety, especially in an emergency context. The management of this intraoperative anxiety is essential for the comfort.
- Trial name
- RELAX (NCT06436118)
- Testing
- RELAX® glasses
- Where
- France
- Volunteers
- 171 people
- Sponsor
- Centre Hospitalier de Valenciennes
Quality of Life (QOL), Decision Making
Peri-Operative Surgical Care Optimisation for Patients Requiring Emergency Surgery
Emergency General Surgery (EGS) is an umbrella term which describes all patients presenting to hospital with an acute abdominal problem. Patients can have various conditions requiring emergency operations.
- Conditions
- Quality of Life (QOL), Decision Making, Emergency General Surgery
- Trial name
- PERI-SCOPES (NCT06972017)
- Volunteers
- 112 people
- Sponsor
- NHS Greater Glasgow and Clyde
Frailty, Surgery
Retrospective Analysis of Sarcopenia in Older Patients Undergoing Laparotomy
Assess the influence of sarcopenia on outcomes of emergency laparotomy in the over 65 age group
- Conditions
- Frailty, Surgery, Emergencies
- Trial name
- NCT04493710
- Testing
- Sarcopenia estimation
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wirral University Teaching Hospital NHS Trust