Clinical trials: Emergency Laparotomy
Surgical Site Infection, Surgical Wound
Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of IOWI in Preventing SSIs in Emergency Laparotomies
The goal of this clinical trial is to compare the outcomes of High-volume saline irrigation vs Povidone-iodine solution cleaning of the intraoperative incision wound in preventing superficial surgical site infections in patients…
- Conditions
- Surgical Site Infection, Surgical Wound, Surgical Incision, Emergency Laparotomies
- Trial name
- NCT05989386
- Testing
- 0.9% saline solution, Povidone-iodine Swab
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Dow University of Health Sciences
Wound Dehiscence
Burst Abdomen in Emergency Midline Laparotomy: Incidence and Risk
The study was conducted in 250 patients who underwent midline Laparotomy at Kasr Al-Ainy emergency department, Cairo University from August 2017 until March 2018.
- Trial name
- NCT03684902
- Testing
- emergency midline exploratory laparotomy
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Cairo University
Laparotomy, Hernia
Continuous Versus Interrupted Abdominal Wall Closure After Emergency Midline Laparotomy
Patients undergoing primary midline laparotomy for an emergency surgical intervention with a suspected septic focus in the abdominal cavity.
- Trial name
- CONTINT (NCT00544583)
- Testing
- Interrupted sutures, Continuous sutures
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Heidelberg University
Advanced Colorectal Cancer in Elderly Patient
The Management of Complicated Colo-rectal Cancer in Older Patients in the Emergency Setting: the CO-OLDER Study
This is a multicenter observational study aimed to investigate the management of older patients aged 75 years old and over admitted to the emergency department with complicated colorectal cancer.
- Trial name
- CO-OLDER (NCT05788224)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Poissy-Saint Germain Hospital
Surgical Site Infection (SSI)
Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy
Surgical site infection (SSI) remains a major cause of postoperative morbidity following emergency laparotomy, particularly in contaminated and dirty/infected abdominal conditions.
- Trial name
- NCT07696819
- Testing
- Levofloxacin
- Where
- Bangladesh
- Volunteers
- 90 people
- Sponsor
- Sylhet M.A.G.Osmani Medical College
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Hernia Incisional, Suture, Complication
DuraMesh Laparotomy Closure Following Trauma and Emergency Surgery
The proposed project aims to evaluate the safety of DuraMesh™ suture for laparotomy closure in an emergent setting, while also providing preliminary efficacy data with regard to incisional hernia prevention.
- Trial name
- NCT04312165
- Testing
- Duramesh Laparotomy Closure, Conventional suture closure
- Where
- 2 sites in United States
- Sponsor
- Uniformed Services University of the Health Sciences
Abdomen, Acute
Geographic Influences on Emergency Laparotomy Outcomes
Introduction 'Emergency Laparotomy' is an umbrella term for a set of commonly performed procedures which are known to carry a significant risk of mortality and morbidity.
- Trial name
- NCT02017977
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Incisional Hernia of Midline of Abdomen
Barbed Suture for Emergency Midline Laparotomy Closure
Urgency surgeries are often performed in a stressful setting with critical patient involved. In this context, laparotomy closure can sometimes be the most neglected part of the procedure.
- Trial name
- BAROTOMY (NCT05351970)
- Testing
- Barbed
- Where
- Spain
- Volunteers
- 128 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Peritonitis, Primary Closure
Outcome of Primary vs Delayed Primary Closure of Laparotomy in Dirty Abdominal Wounds
This randomized controlled trial is designed to evaluate and compare two different wound management strategies-primary closure (PC) and delayed primary closure (DPC)-in patients undergoing emergency laparotomy for peritonitis The…
- Conditions
- Peritonitis, Primary Closure, Delayed Primary Closure
- Trial name
- NCT07531576
- Testing
- Delayed Primary Laparotomy wound Closure, Primary Abdominal Closure
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Ayub Teaching Hospital
Surgical Site Infection, Length of Stay
Prevena to Prevent Surgical Site Infection After Emergency Abdominal Laparotomy
Post-operative wound complications in abdominal surgery have a major impact on patient outcomes and the real impact of Closed incision negative pressure therapy (CINVt) is not clear in the literature moreover concerning its…
- Conditions
- Surgical Site Infection, Length of Stay, Seroma, Hematoma
- Trial name
- CiPNT/SSI (NCT04496180)
- Testing
- Closed incision negative pressure therapy versus standard dressing after emergency abdominal laparotomies
- Volunteers
- 334 people
- Sponsor
- University Hospital, Geneva
Emergency Laparotomy
Evaluation of Surgical Risk Prediction Tools.
Introduction: In modern surgery, the prediction of perioperative death gains significant importance due to the availability of treatment options, means of improving the surgical outcome and for proper patient information.
- Trial name
- NCT04615520
- Where
- Greece
- Volunteers
- 660 people
- Sponsor
- University Hospital of Crete
Failure to Rescue, Emergencies
Rescue for Emergency Surgery Patients Observed to uNdergo Acute Deterioration
This is a Five Year programme designed to identify and evaluate human factors interventions to improve the response to patients deteriorating following emergency surgery.
- Trial name
- RESPOND (NCT04919720)
- Testing
- FRAM Model and Human Factors/Quality Improvement Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 9,064 people
- Sponsor
- University of Oxford
Laparotomy, Peritonitis
Standardized Perioperative Management of Patients Operated With Acute Abdominal Surgery in a High-risk Emergency Setting
The objective of the study is to handle patients with the need for an acute laparotomy according to a standardised perioperative protocol and to document the measurement as they are performed (i.e.
- Conditions
- Laparotomy, Peritonitis, Ileus, Perforated Bowel
- Trial name
- SMASH (NCT03549624)
- Testing
- Standardised protocol for the perioperative management in patients in need of an acute laparotomy
- Where
- Sweden
- Volunteers
- 1,435 people
- Sponsor
- Sahlgrenska University Hospital
Wound Infection; Wounds; Dehisence; Cosmesis; Home Care; Length of Hospital Stay
Prophylactic Negative Wound Therapy in Laparotomy Wounds.
Post-operative wound issues in abdominal surgery have a significant impact on patient outcomes. The impact of different types of wound therapy are not clear in the literature.
- Trial name
- PROPEL (NCT03871023)
- Testing
- Smith & Nephew PICO Negative wound pressure versus standard dresing, PREVENA Negative pressure wound versus standard dressing
- Where
- Ireland
- Volunteers
- 240 people
- Sponsor
- St. James's Hospital, Ireland
Midline Laparotomy
Comparison Between Conventional and Modified Smead Jones Method for Mass Closure in Emergency Midline Laparotomy
The occurrence of sudden disruption of abdominal wall laparotomy wound is a major disaster and a major psychological trauma to the patient .
- Trial name
- NCT05199974
- Testing
- Midline abdominal closure
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Incisional Hernia After Midline Laparotomy, Emergency Abdominal Surgery
Prophylactic Mesh Reinforcement Versus Primary Closure After Emergency Midline Laparotomy (PREEMPT)
The PREEMPT trial is a multicenter randomized controlled trial comparing prophylactic onlay biosynthetic mesh reinforcement with primary suture closure in adult patients undergoing emergency midline laparotomy.
- Trial name
- PREEMPT (NCT07753551)
- Testing
- Prophylactic Biosynthetic Mesh Placement, Direct suture
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- University of Rome Tor Vergata
Laparotomy Closure After Abdominal Surgery
Comparing Delayed vs Primary Wound Closure After Emergency Laparotomy: Impact on Infection, Healing, and Hospital Stay
The purpose of this study is to find out which type of wound closure after emergency abdominal surgery leads to fewer wound infections and better recovery: closing the wound immediately after surgery (called primary closure) or…
- Trial name
- NCT07142395
- Testing
- Immediate skin closure, Delayed primary closure
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Bkahtawar Amin Medical and Dental College Multan
Delirium in Old Age
Dexmedetomidine Effect on Delirium of Elderly Patients
The Effect of Dexmedetomidine on the Incidence of Delirium Incidence of Post-operative Delirium in Elderly Patients Undergoing Emergency Laparotomy
- Trial name
- NCT06111300
- Testing
- Dexmedetomidine
- Volunteers
- 86 people
- Sponsor
- Assiut University