Clinical trials: Emergency Patients, active
Chest Pain, Acute Coronary Syndrome
AI-Assisted Interpretation of Cardiac CT in the Emergency Department
This prospective, pragmatic, randomized controlled trial is designed to evaluate the impact of an artificial intelligence (AI)-based coronary computed tomography angiography (CCTA) interpretation tool (Angiomics) on emergency…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- NCT07235657
- Testing
- Angiomics AI-based Coronary CT Interpretation Tool, Standard CCTA Interpretation without AI
- Where
- South Korea
- Volunteers
- 620 people
- Sponsor
- Yonsei University
Nicotine Dependence, Cigarettes, Nicotine Withdrawal
The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community…
- Trial name
- INITIATE (NCT04163081)
- Testing
- Quit Card Intervention (QCI)
- Where
- 4 sites in Canada
- Volunteers
- 1,208 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Suicide, Attempted, Suicide Ideation
Preventing Suicidal Behavior With Diverse High-Risk Youth in Acute Care Settings
This multisite randomized controlled trial will compare two brief interventions for youth and young adults ages 12-24 following an acute care visit for suicide risk: the Stanley-Brown Safety Planning Intervention with follow-up…
- Conditions
- Suicide, Attempted, Suicide Ideation, Suicide, Suicide Prevention
- Trial name
- Project HOPE (NCT06151158)
- Testing
- Stanley Brown Safety Planning Intervention and Follow-up Contacts (SPI+), Interpersonal Psychotherapy for Adolescents Ultra Short Crisis Intervention (IPT-A SCI)
- Where
- 6 sites in United States
- Volunteers
- 484 people
- Sponsor
- Johns Hopkins University
Emergency Delirium, Postoperative Delirium (POD)
Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study
Emergence delirium (ED) is a frequent complication in children undergoing general anesthesia, particularly following ENT procedures such as adenotonsillectomy.
- Conditions
- Emergency Delirium, Postoperative Delirium (POD), Adenotonsillectomy, Tonsillectomy
- Trial name
- CLONIDEX (NCT07913308)
- Testing
- Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
Procedural Pain, Procedural Sedation and Analgesia
Effect of Ketamine on Optic Nerve Sheath Diameter During Procedural Analgesia
The goal of this observational study is to learn whether ketamine given for procedural analgesia changes intracranial pressure in adult emergency department patients.
- Conditions
- Procedural Pain, Procedural Sedation and Analgesia, Intracranial Pressure
- Trial name
- NCT07916064
- Testing
- ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Ankara Etlik City Hospital
Substance Use Disorder (SUD)
Peer Support Workers Study
Many people with high-risk opioid use visit emergency departments (EDs), facing a high risk of death if they leave before completing care.
- Trial name
- NCT07030192
- Testing
- Emergency Department Peer Availability
- Where
- Canada
- Volunteers
- 3,781 people
- Sponsor
- University of British Columbia
Emergency Department, Revisit
Development, Validation, and Clinical Trial of a Prediction Tool for High-Risk Emergency Department Revisits
Emergency department (ED) visits have grown tremendously in Taiwan over the past few years, reaching approximately 7 million visits in 2019.
- Trial name
- NCT07909096
- Testing
- ED-HIKRS, Usual Care
- Volunteers
- 4,010 people
- Sponsor
- National Taiwan University Hospital
Digestive Emergency, New Pathway
Effectiveness of the RAUC Pathway in Reducing Unscheduled Hospitalizations After Emergency Digestive Surgery
The number of emergencies's visits (22 million visits in 2019 in France), the organization of emergencies and the sustainability of the current health system are threatened.
- Conditions
- Digestive Emergency, New Pathway, Connected Health
- Trial name
- RAUCAMIENS (NCT06769438)
- Testing
- ERAS, DEEPSEN, RDS
- Where
- 6 sites in France
- Volunteers
- 3,048 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Concussion, Mild, Traumatic Brain Injury
Improving In-hospital and Post-discharge Patient Education for Mild Traumatic Brain Injury
The purpose of this study is to develop and validate ways to provide better patient education and clinical management for individuals who go to the emergency department (ED) with concussion or mild traumatic brain injury (mTBI).
- Trial name
- EDucate (NCT06595914)
- Testing
- Clinical implementation strategies
- Where
- United States
- Volunteers
- 5,831 people
- Sponsor
- Medical College of Wisconsin
Pulmonary Embolism (Diagnosis)
Clinical Management and Outcomes After Lung Scintigraphy for Suspected Pulmonary Embolism in the Emergency Department
This study will review the medical records of adults evaluated for a suspected blood clot in the lungs (pulmonary embolism) in the emergency department at Antalya Training and Research Hospital.
- Trial name
- NCT07905781
- Testing
- Pulmonary Perfusion Scintigraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Antalya Health Sciences University
Pulmonary Aspiration, Emergency Surgery
Aspiration Risk Assessment by Gastric Ultrasound in eMErgency Surgery and ANesThetic Decision-making: The ARGUMENT Study
Pulmonary aspiration of gastric contents is a serious patient safety problem accounting for 50% of anesthesia-related mortality.
- Trial name
- NCT06303492
- Testing
- GUS
- Where
- Canada
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Acute Thoraco-Abdominal Emergency Lesions
Vision-Language-Based Large-Scale Model for Emergency Screening
This is a single-center, prospective, stratified 1:1 parallel-group randomized superiority diagnostic trial at The First Hospital of Jilin University.
- Trial name
- NCT07899931
- Testing
- powER vision-language large-model assisted CT reading, Conventional CT reading without AI assistance
- Where
- China
- Volunteers
- 640 people
- Sponsor
- The First Hospital of Jilin University
HIV Prevention, Pre-Exposure Prophylaxis (PrEP)
Starting HIV Prevention Medicine (PrEP) During an Emergency Department Visit With a Peer Navigator
The goal of this study is to learn whether adults who visit a hospital emergency department (ED) find it acceptable to start HIV pre-exposure prophylaxis (PrEP) during that same visit, with help from a peer navigator.
- Trial name
- RAPID Response (NCT07901101)
- Testing
- RAPID Response peer navigation, Emtricitabine/tenofovir disoproxil fumarate (F/TDF)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Bronchiolitis, Clinical Phenotype
Short-Term Enteral Nutrition for Infants With Bronchiolitis in Pediatric Emergency Departments
Bronchiolitis is a common viral infection of the small airways that affects infants, particularly during respiratory syncytial virus epidemics.
- Conditions
- Bronchiolitis, Clinical Phenotype, Nutritionnal Impairment, Short-Term Enteral Nutrition
- Trial name
- STENP-PER (NCT07901400)
- Testing
- Usual inpatient bronchiolitis care, STENP-PER care pathway
- Where
- 8 sites in France
- Volunteers
- 448 people
- Sponsor
- Hospices Civils de Lyon
Acute Heart Failure (AHF)
Evaluation of Fibroscan® Performance in Diagnosing Acute Heart Failure in Patients Presenting to the Emergency Department
Acute heart failure (AHF) is a major cause of acute dyspnea in emergency departments (EDs), driven primarily by venous congestion, which can lead to hepatic congestion and risk of subsequent liver dysfunction.
- Trial name
- FIBROSCAF (NCT07449377)
- Testing
- FibroScan®
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pain, Acute
Impact of Vitamin C on opioïd Consumption After an Emergency Department Visit for Acute Musculoskeletal Pain
Recent evidence has shown that vitamin C has some analgesic properties and can therefore reduce opioids used during healing. Vitamin C analgesic effect has been explored mostly during the short-term postoperative context or in…
- Trial name
- NCT05555576
- Testing
- Vitamin C
- Where
- Canada
- Volunteers
- 464 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Sepsis
Comparison of Sepsis Prediction Algorithms
Sepsis is a severe response to infection resulting in organ dysfunction and often leading to death. More than 1.5 million people get sepsis every year in the U.S., and 270,000 Americans die from sepsis annually.
- Trial name
- NCT05943938
- Testing
- Epic Sepsis Model Version - 1, Epic Sepsis Model Version - 2, Emory Sepsis Model
- Where
- 7 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- Emory University
End-of-life Care, Palliative Care
Prehospital Care of End-of-Life Patients by the Strasbourg Mobile Emergency and Resuscitation Service: A Qualitative Study of Healthcare Professionals' Experiences and Use of a Comfort Care Booklet
Prehospital end-of-life care presents complex clinical, ethical, relational, and organizational challenges for healthcare professionals working in the Strasbourg Mobile Emergency and Resuscitation Service (SMUR).
- Conditions
- End-of-life Care, Palliative Care, Prehospital Emergency Care, Healthcare Professionals' Experiences and Perceptions
- Trial name
- PALLI-SMUR1 (NCT07895940)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
HIV Infections
Screen Smart: Using Digital Health to Improve HIV Screening and Prevention
The goal of this interrupted time series quasi-experimental design study is to implement universal opt- out HIV testing and linkage to HIV preventive care in 15-21 year old adolescents visiting the pediatric emergency department…
- Trial name
- Screen Smart (NCT06003192)
- Testing
- Universal Opt-out HIV Screening
- Where
- 4 sites in United States
- Volunteers
- 63,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Communication Research
Evaluating AI for the Translation of KM Resources
Knowledge mobilization resources for parents provide information to help make health decisions for their children. These resources can include videos, infographics, and plain language summaries. They are often created in English.
- Trial name
- NCT07666399
- Testing
- KM Resource - English, KM Resource - Professionally Translated, KM Resouce - AI
- Where
- Canada
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- University of Alberta