Clinical trials: Emergency Treatment, open to volunteers
Stroke, Acute
Acute Stroke: Prehospital Versus In-HospitAL Initiation of Recanalization Therapy- ASPHALT
ASPHALT is an academic-driven open-label randomized controlled trial of Mobile Stroke Unit (MSU) deployment versus standard care in France, with blinded assessment of efficacy endpoints.
- Trial name
- ASPHALT (NCT05649670)
- Testing
- Mobile Stroke Unit deployment
- Where
- 11 sites in France
- Volunteers
- 450 people
- Sponsor
- Centre Hospitalier St Anne
Low Back Pain
A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy
This is a multi-site feasibility trial of an embedded emergency department (ED) physical therapy care model for low back pain at two EDs in the Northwestern Medicine and University of Utah Health systems.
- Trial name
- FEED-PT (NCT07224945)
- Testing
- Embedded Emergency Department Physical Therapy, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Northwestern University
Urinary Tract Infections, Antiobiotic Stewardship
Post-Emergency Optimization of Antibiotic Therapy for Urinary Tract Infection (UTI)
Prospective, multicenter, non-interventional study conducted over 6 months, including patients presenting to the emergency department with suspected urinary tract infection managed as outpatients and discharged with or without…
- Conditions
- Urinary Tract Infections, Antiobiotic Stewardship, Emerging Infectious Disease
- Trial name
- REVIU48 (NCT07559318)
- Testing
- Adaptation of antibiotics therapy for outpatient urinary infection following emergency care
- Where
- 3 sites in France
- Volunteers
- 330 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Hyperkalaemia
AI-Enabled ECG Stratification and Timing of Potassium-Lowering Therapy in Patients With Hyperkalemia: A Target Trial Emulation Study
Hyperkalemia is a common and potentially life-threatening electrolyte disorder, yet there is limited evidence guiding the optimal timing of potassium-lowering therapy in routine clinical practice.
- Trial name
- AIDE-K (NCT07307729)
- Testing
- Timely treatment, Delayed treatment
- Volunteers
- 5,000 people
- Sponsor
- National Defense Medical Center, Taiwan
Vertigo, Dizziness
Prospective Registry of Vertigo Due to Vertebrobasilar Transient Attacks.
Vertigo and dizziness are common neurological complaints in the emergency department and may represent a wide spectrum of etiologies, including vertebrobasilar transient neurological attacks (VB-TNAs).
- Conditions
- Vertigo, Dizziness, TIA (Transient Ischemic Attack), Transient Neurologic Symptoms
- Trial name
- UTRAVERA (NCT07421973)
- Where
- Brazil
- Volunteers
- 400 people
- Sponsor
- University of Sao Paulo General Hospital
Pediatric Emergency Care
The Effect of Using a Stress Ball and Watching Cartoons on Fear and Pain Levels During Enemas in Children Aged 6-12
Aim: The aim of this study is to investigate the effect of using a stress ball and watching cartoons during the enema procedure-performed as part of the diagnosis and treatment process-on the levels of fear and pain in children…
- Trial name
- NCT07754136
- Testing
- Cartoon watching group, Stress ball group
- Where
- Turkey (Türkiye)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Tarsus University
Acute Heart Failure (AHF)
Early Gliflozin for Elderly Patients With Acute Decompensated Heart Failure in the Emergency Department
Background: SGLT2 inhibitors reduce CHF morbidity/mortality but are underutilized in elderly patients with acute decompensated CHF (ADCHF) admitted outside cardiology departments.
- Trial name
- GlifloFastER (NCT07392788)
- Testing
- Early initiation of dapagliflozin 10mg daily within 24h of emergency department admission, Telephone follow-up by cardiac nurse practitioner at 1 month, Standard acute decompensated heart failure care
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Trauma, Injury
Data-Driven Lay First Responder Program in Cameroon
Cameroon experiences a high burden of injury-related morbidity and mortality and currently lacks a formal pre-hospital care system.
- Trial name
- K-LFR Project (NCT07581327)
- Testing
- Lay First Responder (LFR) training
- Where
- Cameroon
- Volunteers
- 1,812 people
- Sponsor
- Sabrinah Christie
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Shortness of Breath
Effectiveness of a Mastery Learning Education Program for Parents of Children Using Inhaler Therapy in an Emergency Unit
Respiratory diseases account for a significant proportion of pediatric emergency department admissions, and effective management of respiratory conditions in children is crucial.
- Trial name
- NCT07452731
- Testing
- Parent Education Program, Routine Care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Emine ŞAHİN
Trauma and Emergency Care, Shock,Hemorrhagic
Delayed Fluids in Hemorrhagic Shock Due to Severe Injuries.
This study will provide information on the quality of care in hemorrhagic shock of severe injuries in a limited resource facility of Latin America, the strategies of fluid resuscitation, and outcomes.
- Conditions
- Trauma and Emergency Care, Shock,Hemorrhagic, Intravenous Fluid Therapy
- Trial name
- PERMIT-LATAM (NCT07530653)
- Testing
- Crystalloid below 1000 mL., IV fluids more than 1,000 mL
- Where
- Colombia
- Volunteers
- 716 people
- Sponsor
- Hospital Departamental de Villavicencio
Supraventricular Tachycardia (SVT)
Adenosine vs Diltiazem for Treatment of SVT in the ED
This is a small, pilot study with a primary goal of assessing patient perceptions of two medication treatments for supraventricular tachycardia in adult patients treated in the Emergency Department.
- Trial name
- COMFORT-ED (NCT06993038)
- Testing
- adenosine, diltiazem
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anne E. Zepeski
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Posttraumatic Stress Symptoms, Burnout
FLOAT for Healthcare PTSS
This early-stage pilot trial aims to examine the feasibility, tolerability, and safety of Floatation-REST, or Reduced Environmental Stimulation Therapy via floatation in frontline healthcare workers, first responders, and…
- Conditions
- Posttraumatic Stress Symptoms, Burnout, Burnout, Healthcare Workers, First Responders
- Trial name
- PTSS FLOAT (NCT07710417)
- Testing
- Floatation-REST, Documentary
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Hyperkalemia
Lower vs. Standard Insulin-Dextrose Doses for Treating Mild to Moderate Hyperkalemia in the Emergency Department
This clinical trial aims to evaluate the safety and efficacy of a lower dose insulin compared to the conventional dose for treating mild to moderate hyperkalemia, a condition characterized by elevated serum potassium levels below…
- Trial name
- IDK+ (NCT06724991)
- Testing
- Lower Dose Therapy, Conventional Dose Therapy
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- University of Malaya
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Opioid Use Disorder, Opioid Overdose
A Bundled Intervention to End Opioid Overdoses
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT07485335)
- Testing
- Bundled intervention (Experimental), control group, Buprenorphine (Experimental)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Alabama at Birmingham
Coronary Artery Calcification, Cardiovascular Risk
Artificial Intelligence - Based Opportunistic Coronary Artery Calcium Scoring on Routine Chest-CT Scan
This retrospective, non-interventional study externally validates a pre-trained open-weight deep-learning algorithm (Swin-UNETR) for the opportunistic quantification of coronary artery calcium (CAC) on non-gated routine chest CT…
- Conditions
- Coronary Artery Calcification, Cardiovascular Risk, Coronary Artery Disease, End-Stage Renal Disease Requiring Haemodialysis
- Trial name
- NCT07808593
- Volunteers
- 1,950 people
- Sponsor
- University of Cologne
Hemorrhage, Thrombosis
Adverse Drug Events in Patients on Oral Anticoagulation in the Emergency Department
Rationale: According to the latest National Survey on Care-Related Adverse Events, anticoagulants, including vitamin K antagonists (VKAs), rank first among medications responsible for serious iatrogenic accidents (37% in 2004…
- Conditions
- Hemorrhage, Thrombosis, Anticoagulant Therapy, Traumatic Hemorrhage
- Trial name
- ADEOA (NCT06692504)
- Where
- France
- Volunteers
- 2,080 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon