Clinical trials: Emerging Infectious Disease
Coronavirus, Respiratory Infection
Prospective Clinical Evaluation of the BioFire Emerging Coronavirus Panel for the Detection of COVID-19 and Other Coronaviruses
The Biomedical Advanced Research and Development Authority (BARDA) has contracted BioFire Defense (BFDf) to develop the BioFire Emerging Coronavirus (ECoV) Panel, a nucleic acid test capable of detecting coronaviruses from…
- Conditions
- Coronavirus, Respiratory Infection, COVID
- Trial name
- NCT07221097
- Testing
- Investigational IVD for coronaviruses
- Where
- 6 sites in United States
- Volunteers
- 2,091 people
- Sponsor
- BioFire Defense LLC
Leishmaniasis, Leptospirosis
Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases
Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments).
- Conditions
- Leishmaniasis, Leptospirosis, Brucellosis, Q Fever
- Trial name
- SEZAM (NCT06859619)
- Testing
- Peripheral venous blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- University Hospital, Montpellier
Invasive Fungal Disease
FungiScope - A Global Emerging Fungal Infection Registry
The objective of this registry is to broaden the knowledge on epidemiology, diagnostic procedures and clinical course of emerging invasive fungal infections.
- Trial name
- FungiScope (NCT01731353)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University of Cologne
Lassa Fever
ARN-75039 Lassa Fever Treatment in West Africa
This multicenter, randomized, open-label Phase 2 clinical trial evaluates the safety, tolerability, and virologic efficacy of ARN-75039, a novel oral antiviral, for treating Lassa fever in hospitalized adults in West Africa.
- Trial name
- NCT07419373
- Testing
- ARN-75039 high, Intravenous ribavirin, ARN-75039 low
- Where
- 4 sites in United States, Nigeria
- Volunteers
- 135 people
- Sponsor
- Arisan Therapeutics, Inc.
Alcohol Use, Marijuana Use
Emerging Adults Who Use Alcohol and Marijuana
The purpose of this study is to if a brief motivational intervention, compared to health education sessions, reduces alcohol and marijuana use and is related to fewer sexually transmitted infections (STI)in emerging adults who…
- Conditions
- Alcohol Use, Marijuana Use, Sexually Transmitted Infections
- Trial name
- HEAT (NCT01473719)
- Testing
- motivational intervention, health education
- Where
- United States
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Hepatitis, Liver Diseases
Evaluation of Orthohepevirus C Infection as an Emerging Cause of Zoonotic Origin Disease
The main objective of this study is to evaluate the prevalence and the clinical impact of Orthohepevirus C infection in different human populations, and to determine its zoonotic origin comparing the sequences obtained in both…
- Conditions
- Hepatitis, Liver Diseases, Acute Hepatitis, Chronic Hepatitis
- Trial name
- NCT05062967
- Where
- 10 sites in Spain
- Volunteers
- 3,257 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Uveitis
ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study)
The study aims to evaluate the potential role of ACTH gel in the management of non-infectious uveitis.
- Trial name
- ACTHAR (NCT02931175)
- Testing
- ACTH gel
- Where
- 7 sites in United States
- Volunteers
- 28 people
- Sponsor
- Quan Dong Nguyen
Coronavirus Infection (COVID-19)
CORE Study COVID-19
This is a Brazilian version of the Clinical Characterization Protocol for Serious Emerging Infections (ISARIC/WHO ). This is a standardized protocol for the rapid, coordinated clinical investigation of Coronavirus disease…
- Trial name
- NCT04531202
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- D'Or Institute for Research and Education
Infectious Diseases and Manifestations
Cohort of the Specialist Network Infectious Diseases
This observational study aims to collect standardized clinical data and biosamples from adults in university hospitals across Germany.
- Trial name
- SNID (NCT06879184)
- Where
- Germany
- Volunteers
- 15,000 people
- Sponsor
- Goethe University
Hiv
SHARE Program: SUSTAIN
The goal of PROJECT SUSTAIN is to optimize Healthy Choices to advance an adaptive and scalable intervention designed to improve self-management of alcohol and HIV in Young People with HIV (YPWH) while understanding the context…
- Trial name
- NCT06934395
- Testing
- Healthy Choices, Text Message Prompts
- Where
- 4 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Florida State University
Patient Engagement, COVID-19
Collaborative Open Research Initiative Study (CORIS-1)
The Collaborative Open Research Initiative Study (CORIS) is a groundbreaking international research endeavor aimed at exploring vital topics within the field of health professions education.
- Conditions
- Patient Engagement, COVID-19, Preventable Disease, Vaccine, Burnout, Professional
- Trial name
- CORIS-1 (NCT06357650)
- Testing
- No intervention. This is an observational study
- Volunteers
- 15,000 people
- Sponsor
- Chisquares Incorporated
Mpox (Monkeypox), Monkeypox Virus Infection
DiagRaMIE Mpox Virus-RDC for the Diagnostic of Monkeypox
Monkeypox, caused by a virus in the Orthopoxvirus genus, is a zoonotic disease first identified in 1970 in the Democratic Republic of Congo (DRC).
- Trial name
- DiagRaMIE Mpox (NCT06840197)
- Testing
- NG-TestⓇ Monkeypox virus kit
- Where
- 3 sites in Republic of the Congo
- Volunteers
- 197 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV-1 Infection
Pilot Study to Assess the Impact of a Mobile Health Application (App) on Clinical Outcomes and Satisfaction of Older HIV-Infected Patients, as an Emerging Tool for Care, Education and Prevention.
In recent years, HIV care has been reframed by the concepts of the HIV care and prevention. The success of these strategies will depend on integrated prevention and care system and sustained behavioral modification.
- Trial name
- NCT04137016
- Testing
- Mobile application
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Febrile Illness
Epidemiology and Clinical Characteristics of Emerging and Re-emerging Infectious Diseases With Epidemic Potential in Mali
This is a prospective observational study to include participants with a spectrum of emerging or unknown pathogens with the objective to determine etiology and clinical characteristics of those diseases.
- Trial name
- ECERID (NCT05441800)
- Testing
- Observational Study
- Where
- Mali
- Volunteers
- 400 people
- Sponsor
- University Clinical Research Center, Mali
Transfusion-Transmitted Infectious Disease
Mirasol Evaluation of Reduction in Infections Trial
This is a prospective, randomized, double-blind, controlled study to determine the effectiveness of Mirasol-treated fresh whole blood (FWB) versus Standard-issue FWB for preventing transmission of transfusion-transmitted…
- Trial name
- MERIT (NCT03737669)
- Testing
- Mirasol-treated Fresh Whole Blood, Standard Fresh Whole Blood
- Where
- Uganda
- Volunteers
- 2,000 people
- Sponsor
- Johns Hopkins University
Urinary Tract Infection
Microbiological Characterization and Antibiotic Resistance Profiling of Providencia Spp,: An Emerging Pathogen Isolated From Urinary Tract Infections
Aims of the Research: 1. Isolation and identification of Providencia spp. from UTIs. 2. Genotypic confirmation of Providencia isolates. 3. Determination of antimicrobial sensitivity patterns of isolated Providencia spp. 4.
- Trial name
- NCT07204769
- Testing
- Antibiotic sensitivity
- Where
- Egypt
- Volunteers
- 241 people
- Sponsor
- Assiut University
Mild Leptospirosis
Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) in Patients With Mild Leptospirosis and Seen at the Hospital in 5 French Overseas Departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte)
Leptospirosis is a globally distributed neglected tropical disease affecting subtropical and tropical areas, such as the Caribbean and the Indian Ocean, with favorable climatic conditions for disease transmission.
- Trial name
- LEPTO3 (NCT04211649)
- Testing
- 3 days of antibiotherapy
- Where
- 5 sites in French Guiana, Guadeloupe and 3 more
- Volunteers
- 220 people
- Sponsor
- University Hospital Center of Martinique
Occupational Accidents, Incubation Period, Infectious Disese
Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases
Background: Increased clinical attention has been paid to the evaluation and management of bioterrorism-related illness (such as anthrax infection) and emerging infectious diseases (such as Severe Acute Respiratory Syndrome…
- Trial name
- NCT01200953
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Emerging Infectious Diseases and Their Treatments
Biological Collection on Emerging Infectious Diseases and Their Treatments
Unprecedented changes in human-environment interactions and increasing disruptions to ecosystems and the climate have contributed to the emergence of infectious diseases (Emerging Infectious Diseases, EIDs).
- Trial name
- COMETE (NCT07674550)
- Where
- France
- Volunteers
- 5,300 people
- Sponsor
- University Hospital, Toulouse
Infectious Diseases in Febrile Patients Returning From Tropical Countries
Rapid Molecular Diagnosis and Detection of Emerging Infectious Diseases in Patients With Tropical Fever (Tropifever)
Travellers returning from tropical countries often present to emergency departments with acute fever. While systematic screening for malaria is well established in clinical practice in France, further diagnostic testing for…
- Trial name
- Tropifever (NCT06539325)
- Testing
- Diagnosis algorithm according to the delay between travel and consultation
- Where
- France
- Volunteers
- 564 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris