Clinical trials: Emesis and Diarrhea
Diarrhea, Fever
Safety and Immunogenicity Assessment of Rotavin-M1 in Vietnamese Children
This is a multiple-site phase 2b, randomized, placebo control study to evaluate the safety and immunogenicity of Rotavin-M1, produced by the Center for Research and Production of Vaccines and Biologicals, Vietnam.
- Conditions
- Diarrhea, Fever, Nausea, Vomit
- Trial name
- Rotavin-M1 (NCT01502969)
- Testing
- Rotavin-M1, cell culture medium in absence of virus
- Where
- 2 sites in Vietnam
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- National Institute of Hygiene and Epidemiology, Vietnam
Gastrointestinal Health
Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions
US residents who have gastrointestinal issues sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of three arms.
- Trial name
- NCT05465629
- Testing
- VIOME Precision Nutrition Program, VIOME-designed condition-based supplements
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Viome
Asthma, Diarrhea & Vomiting
Best Strategies for Implementation of Clinical Pathways in Emergency Department Settings
An Ontario-wide study to identify best strategies to promote uptake of high quality, expert developed Clinical Pathways (CPs) within Emergency Departments.
- Trial name
- NCT01815710
- Testing
- Pediatric Asthma Clinical Pathway, Vomiting & Diarrhea Pathway
- Where
- Canada
- Volunteers
- 6,330 people
- Sponsor
- Children's Hospital of Eastern Ontario
Diarrhea, Fever
Trial Of Azithromycin In Campylobacter Concisus Patients With Diarrhea
A randomized, double-blind, placebo-controlled clinical trial of azithromycin in Campylobacter concisus culture positive patients with diarrhea.
- Conditions
- Diarrhea, Fever, Vomiting, Abdominal Pain
- Trial name
- Concisus2012 (NCT01531218)
- Testing
- azithromycin
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Dehydration, Gastroenteritis
Ondansetron Administration to Children With Gastroenteritis, Vomiting and SOME Dehydration in EDs in Pakistan
The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children…
- Conditions
- Dehydration, Gastroenteritis, Vomiting, Diarrhea
- Trial name
- OSEP (NCT01870648)
- Testing
- Ondansetron
- Where
- 2 sites in Pakistan
- Volunteers
- 918 people
- Sponsor
- Dr. Stephen Freedman
Dehydration, Acute Gastroenteritis
Comparing Speedlyte and IV Rehydration Treating Children With Gastroenteritis in a Pediatric Emergency Department (ED)
To compare length of stay (LOS) of pediatric patients in a pediatric emergency room presenting with Gastroenteritis treated with IV rehydration versus oral Speedlyte rehydration.
- Trial name
- NCT03562702
- Testing
- Standard IV Rehydration Therapy, Oral Rehydration Therapy (ORT)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Diarrhea, Fever
A Dose-escalating Study to Evaluate the Immunogenicity and Safety of Rotavin-M1 Vaccine in Healthy Infants
The purpose of this study is to evaluate the safety and immunogenicity of Rotavin-M1 produced by the Center for Research and Production of Vaccines and Biologicals (POLYVAC) in infants in Vietnam.
- Conditions
- Diarrhea, Fever, Nausea, Vomit
- Trial name
- NCT01377571
- Testing
- Rotarix
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Hygiene and Epidemiology, Vietnam
Cancer
The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms"
The aim of the study is to identify how often gastrointestinal problems interfere with quality of life as a result of treatment for cancer with chemotherapy.
- Trial name
- FOCCUS (NCT02121626)
- Where
- United Kingdom
- Volunteers
- 248 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Acute Gastroenteritis, Diarrhea
Surveillance Study of Acute Gastroenteritis in Hospitalized Children
Acute gastroenteritis is a common cause of hospital admission and health office visits and have a huge burden on the economy of developing countries.
- Conditions
- Acute Gastroenteritis, Diarrhea, Dehydration
- Trial name
- SAGE (NCT02245139)
- Volunteers
- 198 people
- Sponsor
- Shaikh Ragheb Harb Hospital
Oral Mucositis, Nausea
ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial
RATIONALE: Polymerized (cross-linked) sucralfate malate paste (ProThelial) may be an effective single therapy approach for the management of chemoradiation mucositis, treating and preventing its occurrence in the oral cavity…
- Conditions
- Oral Mucositis, Nausea, Vomiting, Diarrhea
- Trial name
- NCT02016807
- Testing
- ProThelial
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Ashley Downs Bioscience
Vomiting, Diarrhea
Developing World Study for RotaTeq™ (V260-015)(COMPLETED)
The purpose of the current study is to evaluate whether the vaccine is effective, well-tolerated and immunogenic among infants in developing countries.
- Conditions
- Vomiting, Diarrhea, Fever
- Trial name
- NCT00362648
- Testing
- RotaTeq™ - Rotavirus Vaccine, Live, Oral, Pentavalent
- Volunteers
- 7,504 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diarrhea, Vomit
Safety Study of a Rotavirus Vaccine (Rotavin-M1) Among Healthy Adults
The purpose of this study is to evaluate the safety of Rotavin-M1 produced by the Center for Research and Production of Vaccines and Biologicals (POLYVAC) in adult volunteers in Vietnam.
- Conditions
- Diarrhea, Vomit, Fever, Nausea
- Trial name
- NCT01375907
- Testing
- Rotavin
- Where
- Vietnam
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Hygiene and Epidemiology, Vietnam
Acute Gastroenteritis, Viral Illness
Multi-DOSE Oral Ondansetron for Pediatric Acute GastroEnteritis
A phase III, double-blind, parallel-design, randomized, placebo-controlled trial to compare multi-dose oral Ondansetron with placebo as treatment for vomiting secondary to acute gastroenteritis (AGE), after Emergency Department…
- Conditions
- Acute Gastroenteritis, Viral Illness, Vomiting, Diarrhea
- Trial name
- DOSE-AGE (NCT03851835)
- Testing
- Ondansetron Oral Solution
- Where
- 6 sites in Canada
- Volunteers
- 1,030 people
- Sponsor
- University of Calgary
Treatment-related Gastrointestinal Toxicity (Including Diarrhea, Constipation, Nausea, and Vomiting), Extrapulmonary Neuroendocrine Neoplasms
Fecal Microbiota Transplantation for Preventing Gastrointestinal Symptoms in Extrapulmonary Neuroendocrine Neoplasms: A Real-World Study
Existing studies have demonstrated that patients with different types of tumors exhibit significant increases in Enterobacter and Staphylococcus genera, along with marked decreases in Lactobacillus, Bacteroides, Bifidobacterium…
- Trial name
- FMT-NENs (NCT06924645)
- Testing
- Fecal Microbiota Transplant (FMT), Standard Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Alpha-Gal Syndrome, Irritable Bowel Syndrome
GI Alpha-Gal Study
This is a double-blind, crossover food challenge study using pork with and without α-gal in patients with a clinical diagnosis of gastrointestinal (GI)- α-gal allergy, and to investigate the pathophysiology underlying their…
- Conditions
- Alpha-Gal Syndrome, Irritable Bowel Syndrome, Diarrhea, Abdominal Pain
- Trial name
- NCT06268717
- Testing
- Ground pork containing alpha-gal, Pork meat not containing alpha-gal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Gastroenteritis Acute, Gastrointestinal Symptoms
Diagnostic PCR Panel in Children With Acute Gastrointestinal Symptoms
This investigator-initiated randomized controlled trial compares the clinical impact of real time PCR of fecal samples in children with acute gastrointestinal symptoms at a pediatric emergency room.
- Conditions
- Gastroenteritis Acute, Gastrointestinal Symptoms, Abdominal Pain/ Discomfort, Vomiting in Infants and/or Children
- Trial name
- RealCAGI RCT (NCT07280624)
- Testing
- Multiplex PCR gastrointestinal panel
- Volunteers
- 526 people
- Sponsor
- University of Oulu
Gastroenteritis, Gastritis
BEKINDA (Ondansetron 24 mg Bimodal Release Tablets) for Vomiting Due to Presumed Acute Gastroenteritis or Gastritis
Randomized, Placebo-Controlled, Phase 3 Trial of RHB-102 (BEKINDA) (Ondansetron 24 mg Bimodal Release Tablets) for Acute Gastroenteritis.
- Trial name
- GUARD (NCT02246439)
- Testing
- RHB-102
- Where
- 26 sites in United States
- Volunteers
- 330 people
- Sponsor
- RedHill Biopharma Limited
Acute Gastroenteritis, Vomiting
Infectious Etiology of Vomiting in Children With Presumed Acute Gastroenteritis
In children with acute gastroenteritis (AGE), vomiting often precedes diarrhea. To establish the diagnosis of AGE, enteropathogen detection typically relies on diarrheal stool samples.
- Trial name
- NCT05270291
- Testing
- rectal swab
- Where
- Poland
- Volunteers
- 198 people
- Sponsor
- Medical University of Warsaw