Clinical trials: Emotional Blunting
Anhedonia, Emotional Blunting
Psilocybin as a Novel Therapy for Residual Anhedonia
This study is for adults with major depressive disorder (depression) who are currently taking an SSRI or SNRI antidepressant but continue to experience anhedonia (reduced interest or pleasure) and emotional blunting.
- Trial name
- NCT07607938
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Depression
Effect of Individualized Precise TMS on Emotional Blunting in Depression and Its Brain Imaging Mechanism
This study aims to explore and investigate the therapeutic effect and mechanism of individualized localization of transcranial magnetic stimulation on emotional blunting of depression, improve the understanding of the mechanism…
- Trial name
- NCT05555940
- Testing
- Transcranial magnetic stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xijing Hospital
Schizophrenia, Undifferentiated Type
Comparison of the Effects of Aripiprazole and Risperidone on the Pattern of Brain Activation in Schizophrenic Patients
After an initial screening visit, including an assessment of psychiatric disorders, patients stabilized on antipsychotic medication (aripiprazole or risperidone) for at least 6 weeks and control subjects will undergo an…
- Trial name
- NCT01109147
- Testing
- Imagery, pharmacogenetic sampling
- Where
- 2 sites in France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Qualissima
Mood Disorders, Emotional Blunting
Validation of the Chinese Version of Oxford Depression Questionnaire
Mood disorders are a group of psychiatric disorders that can affect a person's mood, energy, and motivation. Emotional blunting has been observed in clinical practice in patients with mood disorders.
- Trial name
- NCT05535270
- Testing
- Oxford Depression Questionnaire (ODQ)
- Where
- China
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Blunted Emotion in Major Depressive Disorder
Lumateperone Added to Antidepressant Therapy in Adults With Major Depressive Disorder Experiencing Emotional Blunting
The purpose of this study is to evaluate whether or not adding lumateparone to current antidepressant treatment in adults with major depressive disorder experiencing blunted emotion will reduce or eliminate the blunted emotion as…
- Trial name
- NCT07824206
- Testing
- lumateparone 42 mg once daily, lumateparone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Future Options Research, LLC
Major Depressive Disorder, Sexual Behavior
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling
Large register based work has shown that starting on oral contraceptives (OCs) is associated with an increased risk of developing depressive episodes.
- Conditions
- Major Depressive Disorder, Sexual Behavior, Mood Disturbance, Mood Change
- Trial name
- NCT05212389
- Testing
- Femicept
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Fear
The Effects of Acetaminophen on Fear
This study investigates the effects of acetaminophen on behavioral, physiological, and self-report fear responses.
- Trial name
- NCT05396677
- Testing
- Acetaminophen
- Where
- Canada
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Guelph