Clinical trials: Emotional Processing, active
Schizophrenia, Schizoaffecitve Disorder
Digital Therapeutics for Social Cognitive Function in Schizophrenia Spectrum Disorder
The purpose of this study is to evaluate the safety and preliminary effectiveness of a smartphone-based digital therapeutic application (AffectUs) for improving social cognition, particularly emotion processing and social cue…
- Trial name
- NCT07755605
- Testing
- Digital therapeutic (AffectUs), Psychoeducational materials
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center
Post Traumatic Stress Disorder, Diminished Pleasure
Psychotherapy Effects on Reward Processing in PTSD
The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience…
- Conditions
- Post Traumatic Stress Disorder, Diminished Pleasure, Anhedonia, PTSD
- Trial name
- PERPP (NCT06096740)
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas at Austin
Intellectual Disabilities (F70-F79), Autism Spectrum Disorder
Emotion Processing and Regulation in People With Intellectual Disability
BACKGROUND Intellectual disability (ID) is neurodevelopmental disorder with social impairments, in areas such as interpersonal communication skills and emotion regulation.
- Trial name
- EPRID (NCT06894264)
- Testing
- Emotion regulation
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Emotional Processing, Mood
Combined Blood Pressure Medication and Activity Scheduling for Low Mood
This study explores the effects of 7-day losartan (50mg) versus placebo with brief behavioural activation on emotional processing in young volunteers low in positive mood
- Trial name
- NCT07017023
- Testing
- Losartan with BA
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression - Major Depressive Disorder, Irritability
Fluoxetine on Emotional Experience (FLEX) Study
The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1.
- Conditions
- Depression - Major Depressive Disorder, Irritability, Depression
- Trial name
- FLEX (NCT07424781)
- Testing
- Fluoxetine
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Cannabis Use Disorder, Severe
Cannabis and Processing Emotions Study
The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic…
- Trial name
- CAPE (NCT06907979)
- Testing
- TMS - Active iTBS, TMS - Active cTBS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Auburn University
PTSD, Military Activity
Art Therapy and Emotional Well Being in Military Populations With Posttraumatic Stress Symptoms
Art therapy is used across the Military Health System for treatment of posttraumatic symptoms, but there is limited research on how art therapy is able to restore emotional expression and regulation in service members.
- Conditions
- PTSD, Military Activity, Post-Traumatic Headache, Posttraumatic Stress Disorder
- Trial name
- NCT05414708
- Testing
- Art Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Walter Reed National Military Medical Center
Self Harm, Suicide, Attempted
Emotional Dysregulation in Para-suicidal Behavior
This is a naturalistic cohort pre-post study investigating aspects of emotional processing and how possible changes in emotional processing is related to the successful treatment of non-suicidal self-injury and suicidal ideation…
- Conditions
- Self Harm, Suicide, Attempted, Emotional Instability, Borderline Personality Disorder
- Trial name
- NCT03846375
- Testing
- Psychotherapy, Pre-intervention testing
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Mild-to-Moderate Stress
Prebiotic Effects on Anxiety, Cortisol, and Emotional Processing in Mild-to-Moderately Stressed Adults
The levels of stress that we experience as a population are continuing to rise due to financial, social and work pressures, particularly in mid-life where additional factors such as family and career often compound these issues.
- Trial name
- PEACE (NCT06991023)
- Testing
- Prebiotic (Bimuno®)
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- University of Reading
Substance Use Disorder (SUD), Addiction
NLP Analysis of Weekly Narratives for Dynamic Clinical Assessment in SUD
This prospective observational study follows adults undergoing residential rehabilitation for severe substance use disorders at a specialized treatment center in Mexico.
- Conditions
- Substance Use Disorder (SUD), Addiction, Anxiety, Emotional Dysregulation
- Trial name
- DYNA-NLP (NCT07595614)
- Testing
- Residential rehabilitation as usual
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Lauro Gutiérrez Castro
Healhty
Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention
The goal of this clinical trial is to learn how 24 IU oxytocin (OT) and 24 IU arginine vasopressin (AVP), administered through the oral mucosa, affect attention to emotional faces and related brain activity in healthy adults.
- Trial name
- NCT07838493
- Testing
- Oxytocin (OT), Arginine Vasopressin (AVP)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Learning, Cognitive Functioning
Dual Orexin Antagonism and Emotion and Affective Processing Study
In this study, the investigators will examine the effects of blocking the orexin system on human behaviour and brain function using daridorexant, a medication that inhibits orexin activity.
- Conditions
- Learning, Cognitive Functioning, Emotional Processing
- Trial name
- DOREA (NCT07267559)
- Testing
- Daridorexant 50 mg
- Where
- United Kingdom
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Alcohol Use Disorder, Intermittent Explosive Disorder
Neural Correlates During Alcohol Intoxication
Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and…
- Trial name
- NCT06118580
- Testing
- Alcohol (Ethanol)
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Autism, Sleep Disturbances in Children
Differences in Rest, Emotion, and Arousal Modulation in Youth
The goal of this study is to examine the relationship between sensory responsivity, bedtime arousal levels, sleep disturbances, and daytime emotion dysregulation for autistic children (ages 6-10).
- Conditions
- Autism, Sleep Disturbances in Children, Sleep
- Trial name
- DREAMY-Autism (NCT07476937)
- Testing
- Power Down bedtime manipulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Autism, Sleep Disturbance
The Power Down Pilot Study: A Novel Bedtime Manipulation Protocol
The goal of this pilot intervention study is to examine the feasibility and acceptability of a novel bedtime manipulation protocol called "The Power Down" for autistic youth, ages 6-10.
- Trial name
- NCT06386029
- Testing
- Power Down bedtime manipulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Psychopathy
Effects of Transcranial Magnetic Stimulation on Social Cognition, Cognitive Processing, and Functional Brain Architecture
This clinical trial will examine whether transcranial magnetic stimulation (TMS), a noninvasive form of brain stimulation, can influence social cognition, cognitive processing, and brain function in adults with elevated…
- Trial name
- NCT07635940
- Testing
- continuous theta burst stimulation (cTBS), Intermittent theta burst stimulation (iTBS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Generalised Anxiety Disorder, Anxiety Disorders
CBT and the Neural Circuits of Anxiety
This study will aim to test whether specific neural circuitry changes, proposed on the basis of a neurocognitive model of anxiety, are a mechanism of action for Cognitive Behavioural Therapy (CBT) interventions.
- Conditions
- Generalised Anxiety Disorder, Anxiety Disorders, CBT, Anxiety Depression
- Trial name
- NCT05549102
- Testing
- Cognitive Behavioural Therapy, Waiting List
- Where
- United Kingdom
- Volunteers
- 174 people
- Sponsor
- UCLH/UCL Joint Research Office
Positive Expectations
Positive Expectation Effects on Early Emotional Processing
Insights into the mechanisms of expectation effects in the emotional domain can be invaluable for the development of potential therapeutic interventions for mood disorders.
- Trial name
- NCT07615530
- Testing
- Saline Nasal Spray
- Where
- Germany
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Emotional Processing, Cognition
7T Amygdala and Citalopram Study
The goal of this study is to investigate how a common antidepressant citalopram (which increases the levels of the chemical messenger serotonin), affects how a key area of the brain involved in depression (the amygdala) responds…
- Conditions
- Emotional Processing, Cognition, Mood Disorders, Depressive Disorder
- Trial name
- 7T FACES (NCT06412315)
- Testing
- Citalopram
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Post-traumatic Stress Symptoms, Anxiety
Psychological Prehabilitation for Complex Gastrointestinal Surgery
The goal of this clinical trial is to learn if a psychological program before surgery can help adults who have lasting stress from past medical experiences. The program is called PREPARE-GI.
- Conditions
- Post-traumatic Stress Symptoms, Anxiety, Depression Disorder, Gastrointestinal Disease
- Trial name
- PREPARE-GI (NCT07865052)
- Testing
- PREPARE-GI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University