Clinical trials: Empyema, Pleural
Haemothorax, Empyema
VATS ( Video-Assisted Thoracoscopy) Compared to Reinsertion of a Thoracostomy Tube for Persistent Haemothorax
This is a prospective, randomized study comparing VATS( Video-Assisted Thoracoscopy ) to reinsertion of a Thoracostomy Tube in patients with retained haemothorax.
- Trial name
- NCT02014077
- Testing
- VATS ( Video-Assisted Thoracoscopy ), Thoracostomy Tube reinsertion
- Where
- South Africa
- Volunteers
- 62 people
- Sponsor
- University of Cape Town
Empyema, Pleural
Retrospective Review on Patients With Culture Negative Empyema
Empyema is associated with a wide range of complication and mortality. It is defined by either a positive pleural fluid culture or grossly pus appearance.
- Trial name
- NCT04477980
- Testing
- Disease outcome (mortality)
- Where
- Hong Kong
- Volunteers
- 153 people
- Sponsor
- Chinese University of Hong Kong
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Pleural Infection, Pleural Diseases
The Oxford Pleural Infection Endotyping Study
Pleural infection is a severe disease with increasing incidence worldwide. The subphenotypes of pleural infection remain unknown.We designed a study to endotype the disease and assess the association between patient phenotype…
- Conditions
- Pleural Infection, Pleural Diseases, Pleural Effusion, Pleural Empyema
- Trial name
- TORPIDS-2 (NCT06513689)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Oxford
Complicated Parapneumonic Effusion, Empyema, Pleural
Flush, Lyse, Operate
The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space.
- Trial name
- FLO (NCT07592520)
- Testing
- Intrapleural Saline with possible escalation to intraplerual alteplase and dornase.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Empyema, Pleural
VATS Decortication Versus IR Guided Chest Tube Insertion With Fibrinolytics for the Management of Empyema
The American Association of Thoracic Surgery defines empyema as pus in the pleural space. It is a common thoracic surgery presentation with an estimated 65,000 cases occurring annually in the United States.
- Trial name
- DICE (NCT03584113)
- Testing
- Video assisted thorascopic decortication, Interventional radiology guided chest tube insertion with MIST2 trial fibrinolytics
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Dr. Wiley Chung
Empyema Thoracis in Children
Early Results of Empyema Thoracis Treatment in Children by Video-assisted Thoracoscopic Surgery
The aim of study is to assess early results of Empyema Thoracis treatment in Children by Video-assisted Thoracoscopic Surgery
- Trial name
- NCT04177550
- Where
- Vietnam
- Volunteers
- 44 people
- Sponsor
- Nhan Pham Nguyen Hien
Pleuritis, Pleural Empyema
Procalcitonin in Pleural Pleuritis
The purpose of this study is to determine pleural level of procalcitonin in differents situations of pleuritis.
- Trial name
- NCT01011881
- Testing
- pleural level of procalcitonin
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pleural Empyema
Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)
Bacterial pneumonia can be complicated by the development of excess fluid and pus (pleural empyema) around the lungs in children. The incidence of pleural empyema in children has increased significantly in the last 10 years.
- Trial name
- NCT01717742
- Testing
- TPA (Tissue Plasminogen Activator), DNase
- Where
- 6 sites in Canada
- Volunteers
- 97 people
- Sponsor
- The Hospital for Sick Children
Pleural Infection
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
- Trial name
- NCT06434324
- Testing
- Saline Irrigation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic