Clinical trials: End Stage Disease
Kidney Failure, Chronic
A Study to Evaluate the Pharmacokinetics and Safety of Golcadomide in Participants With Severe Renal Impairment and End-Stage Renal Disease Compared With Participants With Normal Renal Function
The purpose of this study is to assess the pharmacokinetics and safety of golcadomide (BMS-986369) in matched healthy participants with normal renal function, adult participants with severe renal impairment, and participants with…
- Trial name
- NCT07763418
- Testing
- Golcadomide
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cardiovascular Disease, Diabetic Nephropathy
Effect of a Vitamin D Analogue vs Placebo on p-NT-proBNP in Patients With Type 1 DM and Diabetic Nephropathy
The primary objective is to assess the impact of three months of treatment with an active vitamin D analogue on a risk marker for excess overall mortality and cardiovascular morbidity/mortality in Type 1 diabetic patients with…
- Trial name
- NCT01331317
- Testing
- Paricalcitol
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Peter Rossing
Kidney Failure, Chronic
Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure
Patients with end-stage renal failure have a markedly higher mortality because of cardiovascular events in comparison with the normal population.
- Trial name
- NCT00124969
- Testing
- Amlodipine
- Where
- Germany
- Volunteers
- 356 people
- Sponsor
- Charite University, Berlin, Germany
End Stage Renal Disease on Dialysis, Biocompatibility
Efficiency and Biocompatibility in Hemodiafiltration Procedure
Hemodiafiltration is a modern, increasingly used special hemodialysis method. Compared to hemodialysis, it allows greater clearance of medium- and high-molecular-weight molecules.
- Conditions
- End Stage Renal Disease on Dialysis, Biocompatibility, Anticoagulation, Hemodiafiltration
- Trial name
- NCT06807905
- Testing
- Heparin anticoagulation, Citrate anticoagulation
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
End Stage Renal Disease (ESRD), Kidney Failure, Chronic
Probiotic and Synbiotic Supplements in Hemodialysis Patients
This single-center randomized controlled trial evaluated the effects of natural probiotic and synbiotic supplementation on clinical and biochemical characteristics in adults with end-stage renal disease receiving maintenance…
- Conditions
- End Stage Renal Disease (ESRD), Kidney Failure, Chronic, Hemodialysis
- Trial name
- NCT07531186
- Testing
- Natural Probiotic Supplement, Natural Synbiotic Supplement (Probiotic + Prebiotic Oat Fiber)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
End-stage Renal Disease, Peritoneal Dialysis
The Relationship Between Aortic Pulse Wave, Aortic Calcification and Peripheral Artery Occlusion Disease in Peritoneal Dialysis Patients
Cardiovascular disease (CVD) is the leading cause of mortality in patients with end-stage renal disease (ESRD), which means that it is important to find out risk factors of CVD in order to prevent or treat it.
- Conditions
- End-stage Renal Disease, Peritoneal Dialysis, Aortic Calcification, Peripheral Artery Occlusion
- Trial name
- NCT01945203
- Where
- Taiwan
- Volunteers
- 174 people
- Sponsor
- National Taiwan University Hospital
End-Stage Renal Disease, Hemodialysis
Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis
The investigators hypothesize that an increase in the duration of dialysis session in thrice weekly center hemodialysis may provide better outcome, less morbidity, higher quality of life, lesser requirement of medications, and…
- Trial name
- NCT00413803
- Testing
- 4-hour thrice weekly in center hemodialysis, 8-hour thrice weekly in center hemodialysis
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 410 people
- Sponsor
- Ege University
End Stage Liver Disease, Hepatitis C
DAA Treatment in Donor HCV-positive to Recipient HCV-negative Liver Transplant
This is a single center study for the donation of Hepatitis C Virus (HCV)-positive livers to HCV negative recipient patients, with preemptive, interventional treatment to prevent HCV transmission upon transplantation.
- Trial name
- NCT03208127
- Testing
- Treatment with Direct Acting Antiviral tablet
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Liver Diseases, End Stage Liver Disease
Prehabilitation Intervention to Maximize Early Recovery (PRIMER) in Liver Transplantation
This is a single center, 2-arm, patient-randomized study evaluating the feasibility and potential efficacy of the PRIMER intervention in improving physical function and reducing frailty in adult Liver Transplant candidates.
- Conditions
- Liver Diseases, End Stage Liver Disease, Frailty
- Trial name
- PRIMER (NCT03584646)
- Testing
- Nokia GO Wearable StepTracker, Medication Reminder, Weekly Check-in appointment with study team or provider
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pennsylvania
End Stage Renal Disease
Testing Tissue Sodium Stores in CAPD Patients-Aims 1 & 2
The investigators' overarching goal is to improve long-term outcomes for end stage renal disease (ESRD) patients. In this study we focus specifically on patients receiving peritoneal dialysis (PD).
- Trial name
- NCT02212327
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Mild Traumatic Brain Injury
VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)
Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured.
- Trial name
- NCT06449183
- Testing
- VIDAS® TBI Test [GFAP and UCH-L1 assays]
- Where
- 5 sites in United States
- Volunteers
- 903 people
- Sponsor
- BioMérieux
Feasibility Study, End Stage Renal Disease on Dialysis (Diagnosis)
Developing an Arts-based Intervention for Patients With End-stage Kidney Disease Whilst Receiving Haemodialysis
This research study aims to develop an arts-based intervention for patients with end-stage kidney disease (ESKD) that can be implemented during haemodialysis sessions, and to assess the feasibility of a randomised controlled…
- Trial name
- NCT03629496
- Testing
- Arts-based intervention
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen's University, Belfast
Peritonitis
Effect of Icodextrin on the Treatment Outcome of Peritoneal Dialysis Patients During Acute Peritonitis
The objective of the present study is to evaluate the a prior hypothesis that treatment with icodextrin during acute peritonitis would improve the treatment outcomes of peritonitis complicating peritoneal dialysis.
- Trial name
- NCT01044446
- Testing
- Icodextrin, glucose-based peritoneal dialysate
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
ESRD (End Stage Renal Disease)
Research and Validation of a Big Data-Driven Intelligent Decision-Making System for Hemodialysis
Objectives and Scope:This observational study aims to leverage real-world data from Huashan Hospital to develop an AI-driven intelligent decision-making system for assessing dialysis adequacy in maintenance hemodialysis (MHD)…
- Trial name
- NCT07466329
- Where
- China
- Volunteers
- 778 people
- Sponsor
- Huashan Hospital
Diabetic Nephropathy, Type 2 Diabetes Mellitus
ORIENT: Olmesartan Reducing Incidence of End Stage Renal Disease in Diabetic Nephropathy Trial
The purpose of the study is to evaluate the effectiveness and safety of olmesartan versus placebo on the progression of diabetic renal disease.
- Conditions
- Diabetic Nephropathy, Type 2 Diabetes Mellitus, Proteinuria
- Trial name
- NCT00141453
- Testing
- olmesartan medoxomil
- Where
- 2 sites in China, Japan
- Volunteers
- 577 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Pain, Terminal Illness
Neurotoxic Adverse Effects of Morphine and Oxycodone for Pain in Terminal Patients With Diminished Renal Function
Significant pain is a common condition in dying patients. Continuous subcutaneous infusion (CSCI) of opioids is the cornerstone in treatment of pain in this last phase of life.
- Conditions
- Pain, Terminal Illness, Renal Impairment
- Trial name
- MOSART (NCT03616639)
- Testing
- Oxycodone, Morphine
- Where
- 15 sites in Netherlands
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
End Stage Renal Disease, Dialysis
Peritoneal Membrane Dysfunction in Peritoneal Dialysis Using Metabolomics
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis…
- Trial name
- NCT03964701
- Testing
- no intervention
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Baxter (Hellas) Ltd
End Stage Renal Disease, Hemodialysis
Addition of Heparin to Taurolock-TM CLS in HD Patients With TCC Dose it Improve Catheter Patency Problems ?
Addition of Heparin to the Catheter Lock Solution (CLS): Taurolock-TM will improve the vascular patency compared to Taurolock-TM alone , in hemodialysis patients with Tunneled Cuffed Catheter(TCC) as vascular access.
- Trial name
- NCT00749619
- Testing
- Catheter Lock Solution Taurolidine and Citrate, Catheter Lock Solution :Taurolidine and Citrate and Heparin, Catheter Lock Solution : Heparin
- Where
- Israel
- Sponsor
- Western Galilee Hospital-Nahariya
End-stage Renal Disease, Dialysis
Economic Evaluation of an Education Platform for Patients With End-stage Renal Disease
1600 patients with severe, end stage renal disease or post transplant will be randomised 1:1:1 to either standard therapeutic education; or education using a specific app; or the enhanced interactive app using feedback messages.
- Conditions
- End-stage Renal Disease, Dialysis, Kidney Transplantation
- Trial name
- PIC-R (NCT03090828)
- Testing
- app-based therapeutic education, enhanced app-based therapeutic education
- Volunteers
- 1,600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Locally Advanced Cancer, Metastatic Cancer
Identification of In-hospital Patients in Need of Palliative Care Using a New Simplified Screening Tool
Every day many patients affected by chronic life-limiting illnesses are admitted into Internal Medicine wards, coming from the Emergency Department.
- Conditions
- Locally Advanced Cancer, Metastatic Cancer, Chronic Respiratory Failure, Chronic Heart Failure
- Trial name
- SST2017 (NCT04143230)
- Testing
- Screening for PC by means of two different screening tools
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.