Clinical trials: End Stage Disease
End Stage Renal Disease
Accelerated Mortality on Renal Replacement
The purpose of this study is to prospectively identify blood markers that identify chronic hemodialysis patients at risk for early (<90 days) and late (>= 1 year) mortality
- Trial name
- ArMORR (NCT00505180)
- Volunteers
- 10,018 people
- Sponsor
- Massachusetts General Hospital
Hepatic Encephalopathy, Liver Cirrhosis
Efficacy and Safety of E.Coli Nissle 1917 in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy
The purpose of study to assess the short-term efficacy and safety of probiotic E.coli Nissle 1917 strain comparing to lactulose and rifaximin in patients with mild (Stage 1-2) or minimal hepatic encephalopathy
- Conditions
- Hepatic Encephalopathy, Liver Cirrhosis, End Stage Liver DIsease
- Trial name
- NCT04787276
- Testing
- E.coli Nissle 1917, Lactulose, Rifaximin
- Volunteers
- 42 people
- Sponsor
- Bogomolets National Medical University
Type 2 Diabetes Mellitus
A Phase 3, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 3, Multicenter, Open-label, Long-term Study of SYR-472 (25 mg) in Patients With Type 2 Diabetes Mellitus Complicated by Severe Renal Impairment or End-stage Renal Disease
The purpose of this study is to evaluate the efficacy and safety of trelagliptin when administered at a dose of 25 mg once weekly using placebo as a control in patients with type 2 diabetes mellitus complicated by severe renal…
- Trial name
- NCT02512068
- Testing
- Trelagliptin 25 mg
- Where
- 49 sites in Japan
- Volunteers
- 107 people
- Sponsor
- Takeda
Renal Dialysis
Multi-center Study to Investigate the Effects of Citrasate® on Heparin N Requirements During Hemodialysis Treatment
The purpose of this study is to determine whether the use of Citrasate®, citric acid dialysate enables the reduction of the heparin N (anticoagulant) dose in patients undergoing hemodialysis.
- Trial name
- NCT01092455
- Testing
- Heparin N reduction
- Where
- 8 sites in United States
- Volunteers
- 300 people
- Sponsor
- Randolph Quinn
Hypertension, Hemodialysis
Improving Blood Pressure Control in End-Stage Renal Disease Through a Supportive-Educative Nursing Intervention
The major purpose of this quantitative study is to determine if a 3 month supportive educative nursing intervention incorporating Blood Pressure (BP) education and BP, salt and fluid monitoring, in addition to goal setting and…
- Trial name
- NCT01052220
- Testing
- BP education and BP self-regulation, Supportive Educative Nursing Intervention
- Where
- 2 sites in United States
- Volunteers
- 118 people
- Sponsor
- Wayne State University
Autoimmune Liver Disease, Liver Transplant Disorder
A Study of SIPLIZUMAB in AILD and LT Patients
There is a significant unmet need for safe and effective therapeutic approaches to prevent immune-mediated graft injury and its complications in liver transplant (LT) recipients with autoimmune liver disease (AILD) including…
- Conditions
- Autoimmune Liver Disease, Liver Transplant Disorder, Autoimmune Hepatitis, Primary Sclerosing Cholangitis
- Trial name
- SET-SAIL (NCT06455280)
- Testing
- Siplizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Elizabeth C. Verna
Kidney Transplant Failure, Kidney Function Issue
Trajectories of Glomerular Filtration Rate and Progression to End Stage Renal Disease After Kidney Transplantation
The gold standard for characterizing chronic kidney disease (CKD) is the glomerular filtration rate (GFR), which is commonly estimated in both native and transplanted kidneys for patient monitoring and therapeutic management and…
- Trial name
- TRAJAKT (NCT04226859)
- Testing
- No intervention
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 14,000 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
End Stage Liver DIsease
Mobilization of Stem Cells With G-CSF and Mozobil in Patients With End Stage Liver Disease
A phase I trial to study the safety of mobilization of stem cells with G-CSF and Mozobil in patients with chronic liver disease.
- Trial name
- NCT01711073
- Testing
- Mobilization with G-CSF and Mozobil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Proteonomix, Inc.
Crohn's Disease (CD)
Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD
This is a Phase II, single-center (Cleveland Clinic), two-arm, randomized, parallel-group superiority trial. The two arms will compare IOUS-guided margin selection against standard macroscopic margin selection in patients…
- Trial name
- SMILE-CD (NCT07680283)
- Testing
- IOUS-guided margin selection
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
End-stage Ankle Arthritis (ESAA), Osteoarthritis (OA)
Comparing Ankle Fusion to Ankle Replacement
End-stage ankle arthritis (ESAA) is a debilitating condition associated with severe pain, dysfunction, and reduced quality of life.
- Trial name
- NCT01620541
- Testing
- Ankle Arthrodesis, Ankle Arthroplasty
- Where
- 6 sites in United States
- Volunteers
- 517 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
End Stage Renal Disease
Reveal LINQ™ Evaluation of Fluid
The purpose of this study is to investigate the use of subcutaneous impedance measured with an implanted Medtronic Reveal LINQ™ insertable cardiac monitor for use as a fluid status monitor in hemodialysis patients.
- Trial name
- REEF (NCT02275923)
- Testing
- Reveal LINQ™ Insertable Cardiac Monitor
- Where
- Australia
- Volunteers
- 9 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
End-Stage Renal Disease
Mode of Dialysis Therapy and Outcomes in End Stage Renal Disease (ESRD)
The purpose of this study is: 1. to compare complications and mortality of hemodialysis with those of peritoneal dialysis in Korean end stage renal disease (ESRD) patients; 2.
- Trial name
- NCT00931970
- Where
- 33 sites in South Korea
- Volunteers
- 5,400 people
- Sponsor
- Clinical Research Center for End Stage Renal Disease, Korea
SARS-CoV 2, End Stage Renal Failure on Dialysis
Serological Testing for COVID-19 (SARS-CoV-2) in ESKD
Starting in late 2019, the world is facing a pandemic with the SARS-CoV-2 virus. Patients with end-stage kidney disease and on treatment with renal replacement therapy are high risk patients, as they are unable to maximize social…
- Trial name
- NCT04378686
- Testing
- dialysis
- Where
- 3 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
End-stage Kidney Disease, CD4 T Cells
Effects of High Cut-off (HCO) Hemodialysis on Central Memory CD4+ T and Treg Cells in Patients With End-stage Kidney Disease
In this study, the investigators will evaluate whether CD4+ TCM producing effector cytokines can be distinguished on the basis of their expression of the IL-7 receptor alpha-chain (CD127).
- Conditions
- End-stage Kidney Disease, CD4 T Cells, Central Memory T Cells, Regulatory T Cells
- Trial name
- NCT01103076
- Testing
- Polyamide HD membrane
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier du Centre du Valais
Kidney Failure, Chronic
Characteristics,Treatment Course and Prognosis of Patients Older Than 75 Yrs Old Reaching End Stage Renal Disease (PSPA)
Elderly (i.e.>75 yrs) represent about 40% of incident dialysis patients in the French REIN Registry and are growing population in high income countries.
- Trial name
- PSPA (NCT02910908)
- Where
- France
- Volunteers
- 581 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Anemia of End Stage Renal Disease
TARGTEPO Treatment for Anemia in End Stage Renal Disease (ESRD) Patients Undergoing Peritoneal Dialysis (PD)
The objectives of this study are to assess safety and to evaluate the biologic activity of TARGTEPO treatment in Peritoneal Dialysis patients
- Trial name
- NCT02378662
- Testing
- MDGN201 TARGTEPO
- Where
- 2 sites in Israel
- Volunteers
- 2 people
- Sponsor
- Aevi Genomic Medicine, LLC, a Cerecor company
End Stage Liver Disease, Physical Activity
The Feasibility of a Prehabilitation Program in the Liver Transplant Population at Barnes-Jewish Hospital
The primary outcome of this study is to demonstrate the feasibility of a prehabilitation program at Barnes Jewish Hospital for liver transplant candidates.
- Trial name
- NCT02444273
- Testing
- Exercise
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
End Stage Renal Disease
Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial
This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the…
- Trial name
- NCT01076881
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Universidade Católica de Pelotas
Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD)
Assessment of Plasma and NGAL for the Early Prediction of Acute Kidney Injury After Cardiac Surgery in Adults Study
The study aims to recruit 156 (54 Acute Kidney Injury (AKI);102 non-AKI) patients undergoing Cardio pulmonary bypass (CPB) surgery, including those with Chronic Kidney Disease (CKD) and multiple co-morbidities.
- Conditions
- Acute Kidney Injury (AKI), Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), Estimated Glomerular Filtration Rate (eGFR)
- Trial name
- NGAL (NCT02733328)
- Testing
- CPB Surgery
- Where
- United Kingdom
- Volunteers
- 405 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
End Stage Renal Failure on Dialysis, Vascular Calcification
Theranova Dialyzer and Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD)
The project will be structured in 3 main parts: 1. Effect of sera of ESRD patients on HD using Theranova dialyzer on high-Pi induced vascular calcification in an in vitro model of rat VSMCs. 2.
- Conditions
- End Stage Renal Failure on Dialysis, Vascular Calcification, Oxidative Stress
- Trial name
- NCT03169400
- Testing
- Theranova dialyzer
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Milan