Clinical trials: End Stage Disease
End Stage Renal Disease
Use of Ointments in Prevention of Catheter Related Infections in PD
Peritoneal dialysis (PD) is used for the treatment of end-stage renal disease in approximately 25% of patients requiring dialysis in Canada. The most common complication is bacterial infection or 'peritonitis'.
- Trial name
- NCT00400595
- Testing
- Mupirocin ointment, Polysporin Triple
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Supportive Care, Exercise Adaptations
Intradialytic Exercise and Cognitive Function
Exercise training may improve global and domain-specific cognitive function, mental health, psychological well-being, dialysis efficacy, and health-related quality of life in people with end-stage kidney disease receiving…
- Conditions
- Supportive Care, Exercise Adaptations, Exercise Training Therapy, Clinical Exercise
- Trial name
- EXCOG-HD (NCT07780175)
- Testing
- Resistance Training, Aerobic training, Combination Training
- Where
- Cyprus
- Volunteers
- 60 people
- Sponsor
- University of Thessaly
Cardiovascular Diseases, Cardiovascular Abnormalities
Effect of SNF472 on Progression of Cardiovascular Calcification in End-Stage-Renal-Disease (ESRD) Patients on Hemodialysis (HD)
The primary objective is to assess the effect of 2 dose levels of SNF472 (300 mg and 600 mg) compared to placebo on the progression of coronary artery calcium volume score over a 12-month (52 weeks) period in ESRD patients on HD
- Conditions
- Cardiovascular Diseases, Cardiovascular Abnormalities, Calcifications, Vascular, Endstage Renal Disease
- Trial name
- NCT02966028
- Testing
- SNF472
- Where
- 75 sites in United States, Spain and 1 more
- Volunteers
- 274 people
- Sponsor
- Sanifit Therapeutics S. A.
End-stage Renal Failure
The ONE Study UK Treg Trial
A study to assess cell therapy as a treatment to prevent kidney transplant rejection. The trial will involve purification of naturally occurring regulatory T cells (nTregs) from living-donor renal transplant recipients.
- Trial name
- ONETreg1 (NCT02129881)
- Testing
- Autologous regulatory T Cell Product
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lung Cancer
Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking
RATIONALE: Use of a nicotine inhaler and/or bupropion may be effective in helping people stop smoking and prevent them from starting smoking again.
- Trial name
- NCT00033592
- Testing
- bupropion hydrochloride, nicotine
- Where
- 25 sites in United States, Canada
- Volunteers
- 1,708 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Sevoflurane, Kidney Diseases
Comparing Sevoflurane With Propofol Sedation in ESRF Patients
End-stage renal failure (ESRF) cohorts undergo brachiocephalic fistula(BCF) transposition with supraclavicular block. However, this is inadequate because the incision may extend to the axillary region which requires…
- Conditions
- Sevoflurane, Kidney Diseases, Procedural Hypotension
- Trial name
- NCT04839536
- Testing
- Sevoflurane inhalant product
- Volunteers
- 36 people
- Sponsor
- University of Malaya
End Stage Renal Disease, Hemodialysis Vascular Access Failure
Reduction of Plasma Free VEGF-A Using Low-dose Bevacizumab in Hemodialysis Patients
The primary purpose of this pilot study is to assess the pharmacokinetic profile of low-dose bevacizumab and its effectiveness in reducing plasma free VEGF-A levels safely in hemodialysis patients.
- Trial name
- NCT02695641
- Testing
- 1.25mg bevacizumab, 2.50mg bevacizumab
- Sponsor
- Mayo Clinic
End-Stage Kidney Disease
The Effect of Mindfulness on Emotional Regulations Skills and Quality of Life Among Patients on Hemodialysis
The study aims to investigate how mindfulness-based intervention (MBI) impacts trait mindfulness, cognitive reappraisal, expressive suppression and quality of life in patients with end-stage renal disease (ESRD) undergoing…
- Trial name
- NCT06622200
- Testing
- Mindfulness-based Intervention
- Where
- Jordan
- Volunteers
- 120 people
- Sponsor
- Jordan University of Science and Technology
End Stage Renal Disease
Desensitization Protocol for Highly Sensitized Patients on the Waiting List for Kidney Transplant
The purpose of this study is to determine whether high dose IVIG and B cell depleting agents can be used effectively in highly sensitized wait-listed patients.
- Trial name
- NCT01502267
- Testing
- High dose IVIG and B cell depleting agents
- Where
- South Korea
- Volunteers
- 2 people
- Sponsor
- Seoul National University Hospital
Narrative Medicine, Chronic Disease
Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students
A qualitative study assessing the impact of early narrative medicine practice on Medical Honors Program (MHP) students' attitudes regarding patient-centered interactions, through interviewing patients with chronic or…
- Conditions
- Narrative Medicine, Chronic Disease, Terminal Illness, Cancer
- Trial name
- NCT03041571
- Testing
- Patient Provider Orientation Scale, Interview performed by MHP student
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Hyperactive Delirium, Delirium of Mixed Origin
Effects of Dexmedetomidine in Patients With Agitated Delirium in Palliative Care
The goal of this multi-centre phase I/II open-label, single-arm study is to determine the feasibility, optimal dose, and preliminary efficacy of dexmedetomidine to manage agitated delirium among patients near the end of life…
- Trial name
- NCT04824144
- Testing
- Dexmedetomidine Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Bruyère Health Research Institute.
Breast Cancer, Metastatic Breast Cancer
STOP-HER2: Stopping Trastuzumab in HER2+ MBC
This study is being done to see if anti-HER2 treatment be safely stopped in patients with HER2-positive metastatic breast cancer (MBC) that have had exceptional response to treatment.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, HER2-positive Breast Cancer
- Trial name
- NCT05721248
- Testing
- Cessation of anti-HER2 treatment
- Where
- 13 sites in United States
- Volunteers
- 82 people
- Sponsor
- Dana-Farber Cancer Institute
End Stage Renal Disease, Hemodialysis
Study of a Dialysate Without Acetate on Protein Energy Wasting Syndrome in Chronic Hemodialysis Patient (EASY)
This work aims to study the effect of an acetate-free dialysate on protein-energy wasting syndrome in patients with chronic hemodialysis renal failure, in comparison to a conventional dialysate with acetate.
- Trial name
- EASY (NCT04824885)
- Testing
- Chlorhydric acid based acid concentrate for bicarbonate hemodialysis (medical device)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Renal Failure, End-Stage Renal Disease
Dietary Protein Requirements in Hemodialysis Patients
The primary purpose of this study is to assess dietary protein requirements in clinically stable maintenance hemodialysis (MHD) patients.
- Trial name
- NCT02194114
- Testing
- Protein Diet
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
End-stage Renal Disease
The Study of Association Between Intradialysis Sodium Balance and Clinical Outcomes in Chronic Hemodialysis Patients
The purpose of this study is to determine whether the change of serum and dialysate sodium level during hemodialysis can influence on blood pressure and intradialytic weight gain in chronic hemodialysis patients.
- Trial name
- NCT02487004
- Testing
- hemodialysis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Su-Hyun Kim
End-Stage Renal Disease
Fosrenol for Enhancing Dietary Protein Intake in Hypoalbuminemic Dialysis Patients (FrEDI) Study
Protein-energy wasting, as reflected by a serum albumin <4.0 g/dL, is very common in maintenance hemodialysis (MHD) patients and associated with poor clinical outcomes including high death rates.
- Trial name
- FrEDI (NCT01116947)
- Testing
- Meals during hemodialysis accompanied by lanthanum carbonate to control phosphorus
- Volunteers
- 108 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
End Stage Renal Disease
Examining the Impact of Using Two Dialysers in Parallel on Dialysis Adequacy in Hemodialysis Patients
The purpose of this study is to investigate the effectiveness of using two dialysers to lower the blood mineral levels in people receiving hemodialysis as compared to using one dialyser (usual treatment).
- Trial name
- NCT01539252
- Testing
- Single dialyzer, Two dialyzers
- Where
- 2 sites in Canada
- Volunteers
- 33 people
- Sponsor
- University of Alberta
End Stage Renal Disease, Kidney Transplantation
Bone Mass and Strength After Kidney Transplantation
The purpose of this study is to test whether active vitamin D (calcitriol) protects bones from weakening and protects blood vessels from calcium deposits over the first year of kidney transplantation.
- Conditions
- End Stage Renal Disease, Kidney Transplantation, Bone Loss, Fractures
- Trial name
- NCT02224144
- Testing
- Vitamin D3, Calcitriol
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Columbia University
End Stage Renal Disease, Congestive Heart Failure
Spironolactone Safety in Dialysis Patients
Cardiovascular disease is the leading cause of death and disproportionately prevalent in patients with kidney disease. Spironolactone has been shown to improve survival in the general population with heart failure by up to 30%.
- Trial name
- NCT00328809
- Testing
- spironolactone
- Where
- United States
- Sponsor
- State University of New York - Upstate Medical University
End-Stage Kidney Disease
Evaluate the Survival Benefits of Zemplar Versus Calcijex in Subjects w/ Stage V Chronic Kidney Disease on Hemodialysis
To evaluate the survival benefit associated with Zemplar therapy as compared to Calcijex for the treatment of secondary hyperparathyroidism in subjects with Stage V chronic kidney disease on hemodialysis as measured by time to…
- Trial name
- NCT00062699
- Testing
- Zemplar (paricalcitol injection), Calcijex
- Where
- 60 sites in United States
- Volunteers
- 2,200 people
- Sponsor
- Abbott