Clinical trials: End of Life Patients
Heart Failure
Improvement of Left Ventricular Ejection Fraction in ICD Patients Undergoing Therapy With Sacubitril/Valsartan
The study is aimed to evaluate the improvement of the left ventricular volumes and of the left ventricular ejection fraction in a population of ICD patients with heart failure and left ventricle systolic dysfunction undergoing…
- Trial name
- SAVE-ICD (NCT03935087)
- Testing
- two-dimensional echocardiogram
- Where
- 6 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Neoplasms Malignant, Carcinoma
Existential Distress in Patients with Advanced Cancer and Their Caregivers
Despite the potential for alleviation of existential distress through psychosocial interventions, existential concerns and their impact on health care outcomes of patients and caregivers have not yet been systematically studied.
- Conditions
- Neoplasms Malignant, Carcinoma, Palliative Care
- Trial name
- NCT04600206
- Testing
- Self-report questionnaires
- Where
- 5 sites in Germany
- Volunteers
- 800 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Secondary Hyperparathyroidism Due to Renal Causes, End Stage Renal Failure
Retrospective Analysis of Quality of Life Changes in Patients Undergoing Parathyroidectomy for End-Stage Renal Disease
The purpose of this study is to characterize changes in quality of life in patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease, based on data extracted from an established…
- Trial name
- NCT07151664
- Testing
- Quality of life progression after parathyroidectomy
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Sleep Apnea
Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness"
The meta-analysis "sleep apnea syndrome and arterial stiffness" includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea…
- Trial name
- PWV follow-up (NCT04704401)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 321 people
- Sponsor
- University Hospital, Grenoble
Other Diagnoses, Comorbidities, and Complications
Assessing the Efficacy of an Electronic Discharge Communication Tool
The transition between acute care and community care represents one of the most vulnerable periods in health care delivery, particularly as the complexity of inpatient populations increases.
- Trial name
- NCT01402609
- Testing
- electronic discharge communication tool, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 1,399 people
- Sponsor
- Ward of the 21st Century
Diabetes Mellitus, Type 2
A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to compare the effect of ticagrelor versus placebo in patients with Type 2 Diabetes Mellitus.
- Trial name
- THEMIS (NCT01991795)
- Testing
- Ticagrelor 60 mg
- Where
- 1,237 sites in United States, Argentina and 41 more
- Volunteers
- 19,271 people
- Sponsor
- AstraZeneca
Non-ischemic Cardiomyopathy
Sudden Death Stratification
Sudden cardiac death (SCD) risk stratification is a challenge in non-ischemic cardiomyopathy (NICM). The underlying mechanism of monomorphic ventricular tachycardia (VT) is mostly scar related.
- Trial name
- NCT04607265
- Testing
- Cardiac MRI
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Corona Virus Infection, Stroke
Physiotherapy as a Complimentary Treatment in Reducing Viral-Load, Complications, Death, Expedite Discharge and Improve Quality of Life, Exercise Endurance and Capacity in Stroke Survivors With CoViD-19: A Clinical-Controlled Study
Background: Coronavirus (CoViD-19) positive stroke survivors (SSv) with comorbidities faces possibility for mortality. Study reports success of physiotherapy in CoViD-19 positive SSv with multiple comorbidities.
- Trial name
- NCT04471831
- Testing
- Rehabilitation exercise protocol
- Volunteers
- 30 people
- Sponsor
- University of Lagos, Nigeria
End Stage Renal Failure on Dialysis
Impact of Cold Dialysis in Combination With Intradialytic Exercise in Aspects Related to Quality of Life and Health
Despite the tremendous advances in dialysis technology, hemodialysis (HD) is a significant challenge for dialysis patients and quality of their lives[2].
- Trial name
- REACD (NCT03905551)
- Testing
- Cold Dialysis, Typical Dialysis, Exercise
- Where
- 3 sites in Greece
- Volunteers
- 72 people
- Sponsor
- University of Thessaly
Acute Ischaemic Stroke, Transient Ischaemic Attack
THALES - Acute STroke or Transient IscHaemic Attack Treated With TicAgreLor and ASA for PrEvention of Stroke and Death
Study to investigate if the study drug ticagrelor and ASA is more effective than Placebo (inactive tablet) and ASA in preventing new stroke events
- Trial name
- THALES (NCT03354429)
- Testing
- Ticagrelor
- Where
- 387 sites in Argentina, Australia and 26 more
- Volunteers
- 11,016 people
- Sponsor
- AstraZeneca
Coronary Arterial Disease (CAD), Sudden Cardiac Arrest
Validation of Sudden Cardiac Arrest Risk Factors in Patients With CAD
Long-term sudden cardiac death (abbreviation: SCAR) focuses on improving the predictability of sudden cardiac death (SCD) in patients diagnosed with coronary artery disease.
- Conditions
- Coronary Arterial Disease (CAD), Sudden Cardiac Arrest, Sudden Cardiac Death
- Trial name
- SCAR (NCT07444931)
- Where
- 3 sites in Israel, Moldova and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Tampere Heart Hospital
Ventricular Tachycardia, Ventricular Arrythmia
Preventive VT Substrate Ablation in Ischemic Heart Disease
The investigators hypothesize that preventive VT substrate ablation in patients with chronic ICM, previously selected based on imaging criteria (BZC mass) for their likely high arrhythmic risk, is safe and effective in preventing…
- Conditions
- Ventricular Tachycardia, Ventricular Arrythmia, Sudden Cardiac Death, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- PREVENT-VT (NCT04675073)
- Testing
- Ventricular tachycardia substrate-based radiofrequency ablation
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Centro Medico Teknon
Brain Death, Adults
Pupillometric Evaluation in Patients Declared Brain Dead - a Prospective Quality Control Study
The aim of the study is to verify the reliability of the current purely clinical examination of the pupils (without the support of a pupillometer) in the context of clinically suspected brain death, compared to the results of a…
- Trial name
- INSPECT (NCT06279975)
- Testing
- non-invasive device-supported, automated pupillometry
- Where
- 2 sites in Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Rheumatoid Arthritis
Phase IIb Clinical Study to Assess the Efficacy and Safety of GenSci120 Injection in Patients With Moderately to Severely Active RA Who Have an Inadequate Response to at Least One DMARD
This is a multicenter, randomized, double-blind, parallel, placebo- and active comparator- controlled clinical study conducted in patients with moderately to severely active RA and an inadequate response to at least one DMARD…
- Trial name
- NCT07423533
- Testing
- GenSci120 150 mg, GenSci120 600 mg, GenSci120 1000 mg
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
HCM - Hypertrophic Cardiomyopathy, Sudden Cardiac Death
Left Bundle Branch Pacing in Patients With Hypertrophic Cardiomyopathy After Myectomy
Pilot interventional randomized clinical trial to study the efficacy of left bundle branch pacing in patients with hypertrophic cardiomyopathy after myectomy for the prevention of progression of heart failure, prevent the…
- Conditions
- HCM - Hypertrophic Cardiomyopathy, Sudden Cardiac Death, Left Bundle Branch Pacing, ICD
- Trial name
- LEFTpaceHCM (NCT07372196)
- Testing
- ICD with left bundle branch area pacing (LBBAP), dual-chamber ICD
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Myocardial Infarction
EMPACT-MI: A Study to Test Whether Empagliflozin Can Lower the Risk of Heart Failure and Death in People Who Had a Heart Attack (Myocardial Infarction)
This is a study in adults who had a heart attack (myocardial infarction). The purpose of this study is to find out whether a medicine called empagliflozin helps to lower the chances of having to go to the hospital for heart…
- Trial name
- NCT04509674
- Testing
- Empagliflozin
- Where
- 439 sites in United States, Argentina and 20 more
- Volunteers
- 6,522 people
- Sponsor
- Boehringer Ingelheim
Hypertrophic Cardiomyopathy
Efficacy of Risk Assessment for Sudden Cardiac Death in Patients With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a heart disease characterized by hypertrophy of the left ventricular myocardium and is most often caused by mutations in sarcomere genes.
- Trial name
- NCT04402268
- Testing
- Cardioverter-defibrillator
- Where
- Poland
- Volunteers
- 252 people
- Sponsor
- Poznan University of Medical Sciences
Code Status Discussions With Medical In-patients
Use of the Electronic Medical Record to Screen Code Status Preference Using Death Language
In order to systematically improve code status communication and documentation while clarifying how providers understand code status decisions, we propose the Choice of Diction's Effect Electronic Measures of Resuscitation Study…
- Trial name
- CODE-EMRS (NCT07405710)
- Testing
- Death language
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Cardiovascular Diseases, Arrhythmias, Cardiac
Multicenter Evaluation of Patients Using LATITUDE Monitoring System
The Multitude is a registry of patients who receive commercially available CIEDs that remotely communicate through the LATITUDE monitoring system and transfer data to a central database.
- Conditions
- Cardiovascular Diseases, Arrhythmias, Cardiac, Heart Failure, Sudden Cardiac Death
- Trial name
- Multitude (NCT06311149)
- Where
- 3 sites in Italy
- Volunteers
- 20,000 people
- Sponsor
- University Hospital of Ferrara