Clinical trials: End of Life Patients
Brain Death
Validation of the Apnea Test Performed by High-flow Oxygen Therapy in Patients With Clinical Brain Death
Brain death is a clinical and paraclinical diagnosis established in a known etiological context. It involves the irreversible destruction of cerebral functions in a beating-heart individual.
- Trial name
- APNEAFLOW (NCT05950178)
- Testing
- Apnea test under high-flow oxygenation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Cancer, Coping Skills
Mindfully Optimizing Delivery of End-of-Life Care
The study evaluates the feasibility, acceptability, and preliminary efficacy of a mindfulness meditation-based intervention designed to provide a synergistic solution to the avoidant coping that often inhibits advance care…
- Trial name
- MODEL Care (NCT02367508)
- Testing
- MODEL Care
- Volunteers
- 31 people
- Sponsor
- Indiana University
Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
Improving Clinician Communication Skills (ICCS)
This research study is a randomized trial to evaluate a training program that is designed to improve the communication skills of clinicians.
- Conditions
- Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD), Restrictive Lung Disease, Congestive Heart Failure
- Trial name
- ICCS (NCT00687349)
- Testing
- Training Program Intervention
- Where
- 4 sites in United States
- Volunteers
- 6,086 people
- Sponsor
- University of Washington
Heart Failure With Reduced Ejection Fraction
Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Risk Stratification
A number of large randomized studies have demonstrated the importance of left ventricle ejection fraction (LV EF) for ventrucular tachyarhrythmia's (VT) prediction.
- Trial name
- PERFECT (NCT05539898)
- Testing
- ICD implantation
- Where
- Russia
- Volunteers
- 450 people
- Sponsor
- Astrakhan Federal Centre For Cardiac Surgery
Liver Cancer, Dropout, Patient
A Worldwide Score for Hepatocellular Cancer and Liver Transplantation
The present study has been developed with multiple aims: 1) to refine available models for liver transplantation which would be able to cover the fate of HCC candidates from an ITT point of view; 2) to develop such an approach on…
- Conditions
- Liver Cancer, Dropout, Patient, Recurrence
- Trial name
- TRAIN-SCORE (NCT03595345)
- Testing
- Liver transplantation
- Where
- Belgium
- Volunteers
- 3,100 people
- Sponsor
- European Hepatocellular Cancer Liver Transplant Group
End of Life, Pain
Assessment of the Interest of ANI in the Non-communicating Patient in Palliative Care
Comfort evaluation is one of the major challenges in the palliative care setting, particularly when it comes to non-communicative patients.
- Conditions
- End of Life, Pain, Analgesia
- Trial name
- ANI-CARE (NCT05454202)
- Testing
- ANI
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Neoplasms
End-of-Life Health Care Decisions by Patients With Advanced Cancer
This study is designed to help the investigators understand more about how people plan for their future medical needs, a process known as "advance care planning." The study is under the direction of Michael J.
- Trial name
- NCT02265601
- Testing
- computer-based decision aid, standard care
- Volunteers
- 200 people
- Sponsor
- Milton S. Hershey Medical Center
Urothelial Cancer
A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)
The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic…
- Trial name
- NCT02603432
- Testing
- Avelumab, Best Supportive Care, Following the planned interim analysis for this study: Avelumab
- Where
- 382 sites in United States, Argentina and 27 more
- Volunteers
- 700 people
- Sponsor
- Pfizer
Renal Replacement Therapy, Renal Dialysis
A Clinical Trial of IntensiVE Dialysis
This study will assess clinical outcomes of extended weekly hours of haemodialysis (>= 24 hours per week) compared with standard hours of haemodialysis (<=18 hours/week) in people with ESKD.
- Conditions
- Renal Replacement Therapy, Renal Dialysis, End Stage Kidney Disease, End Stage Renal Disease
- Trial name
- ACTIVE (NCT00649298)
- Testing
- haemodialysis
- Where
- 40 sites in Australia, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- The George Institute
COVID-19, Kidney Injury
Morphofunctional, Gene, Inflammation Molecules and Oxidative Stress Analysis in Kidney Tissue of COVID-19 Patients
The involvement of the kidneys in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the outset of the pandemic was associated with high mortality rates worldwide.
- Conditions
- COVID-19, Kidney Injury, Gene Amplification, Oxidative Stress
- Trial name
- NCT06444893
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
PD-L1 Gene Mutation, PD-L1 Gene Amplification
Programmed Cell Death Ligand 1 PET/CT in Various PD-L1-Related Disease Patients
To evaluate the potential usefulness of 68Ga/18F-PD-L1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various PD-L1-related disease patients
- Conditions
- PD-L1 Gene Mutation, PD-L1 Gene Amplification, PD-L1-related Disease, Positron Emission Tomography
- Trial name
- NCT07618936
- Testing
- Single Group Assignment
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Tianjin Medical University
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Myocardial Infarction, Death
Serum Magnesium Levels in Desalination Tap Water and Outcomes in Acute Myocardial Infarction Patients
Association between serum magnesium and clinical outcome in patients with acute MI (AMI) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (DSW) (Sheba MC) and 150 patients in regions with…
- Conditions
- Myocardial Infarction, Death, Congestive Heart Failure, Acute-MI
- Trial name
- NCT02356393
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Sudden Cardiac Death, Sudden Cardiac Arrest
Wearable Cardioverter Defibrillator in Hemodialysis Patients (WED-HED) Study
A multi-center, prospective, randomized controlled clinical trial with 1:1 assignment of treatment and control. This study will evaluate the impact of wearable cardioverter defibrillator use on sudden cardiac death in incident…
- Trial name
- WED-HED (NCT02481206)
- Testing
- Wearable Cardioverter Defibrillator
- Where
- 31 sites in United States
- Volunteers
- 66 people
- Sponsor
- Zoll Medical Corporation
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Chronic Kidney Diseases
Competing Risk of Death and ESRD in Incident CKD Patients
Although chronic kidney disease (CKD) affects a growing number of people, epidemiologic data on incident CKD in the general population are scarce. Screening strategies to increase early CKD detection have been developed.
- Trial name
- EPIRAN (NCT03379571)
- Volunteers
- 631 people
- Sponsor
- Central Hospital, Nancy, France
Delirium
Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients
The purpose of this study is to determine if melatonin administration to end-of-life patients is effective in preventing the development of delirium compared with those who do not receive this treatment.
- Trial name
- NCT02536417
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- Fraser Health
Neurological Outcome, Survival From First Diagnosis Metastatic Spinal Cord Compression to Death
Emergency Radiotherapy in Metastatic Spinal Cord Compression of Patients With Non-small Cell Lung Cancer
Acute neurological deficit in metastatic spinal cord compression is an emergency condition in radiation oncology. Despite some reports about the high efficacy of radiation treatment for oncological emergencies, a standard of care…
- Trial name
- CK-INF (NCT02000518)
- Testing
- external beam radiotherapy
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Hemodialysis, Cardiac Arrhythmia
Implantable Loop Recorder in Hemodialysis Patients
The purpose of this study is to use implantable loop recorder (ILR) in patients under chronic hemodialysis to record arrhythmias and conduction disorders and correlate them with hemodialysis parameters.
- Conditions
- Hemodialysis, Cardiac Arrhythmia, Cardiac Death
- Trial name
- RYTHMODIAL (NCT01252823)
- Testing
- Implantation of ILR
- Where
- 9 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Bordeaux
Lung Cancer
Epidemiologic Multicenter Prospective Study in Advanced NSCLC (Non Small Cell Lung Cancer) Patients With PDL1 (Protein Death Ligand 1) Expression.
Epidemiologic multicenter prospective study in advanced NSCLC patients with PDL1 expression : evaluation of clinical and pathological characteristics of PDL1 high expression patients compared to patients with a weak or no…
- Trial name
- EXPLORE-PDL1 (NCT02785562)
- Testing
- Assessment of PDL1 expression
- Where
- 13 sites in France
- Volunteers
- 170 people
- Sponsor
- Groupe Francais De Pneumo-Cancerologie