Clinical trials: End of Life Patients
Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
Cluster of Differentiation Antigen 19/22(CD19/22) CAR T Cells (AUTO3) for the Treatment of Diffuse Large B Cell Lymphoma
The purpose of this study is to test the safety and efficacy of AUTO3, a CAR T cell treatment targeting CD19 and CD22 with consolidation or pre-conditioning with anti-PD1 antibody in patients with DLBCL
- Trial name
- ALEXANDER (NCT03287817)
- Testing
- AUTO3
- Where
- 11 sites in United States, United Kingdom
- Volunteers
- 52 people
- Sponsor
- Autolus Limited
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
CPR Decision-Making
Improving Decisions About CPR
Objective The primary objective is to evaluate the efficacy of a multi-faceted, clinical decision support intervention aimed at improving the quality of decisions about Cardio Pulmonary Resuscitation (CPR) for seriously ill…
- Trial name
- iCANACP (NCT03287895)
- Testing
- Decision Support
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Coronary Syndrome, Hypertension
DASH Diet, Quality of Life and Cardiac Parameters of Patients With Acute Coronary Syndrome
The clinical trail study aimed to determine effect of DASH eating plan on cardiac parameters and quality of life in hypertensive individuals diagnosed with acute coronary syndrome. The main questions it aims to answer are: 1.
- Trial name
- NCT06485765
- Testing
- Diet planning
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Bandırma Onyedi Eylül University
Recurrence, Metastasis
The Clinical Relevance of Immune Cells and CTC in HNSCC Patients
Head and neck squamous cell carcinomas (HNSCCs) are mainly caused by tobacco, alcohol consumption and betel nut chewing and the sixth most common cancer in the world.
- Conditions
- Recurrence, Metastasis, Death
- Trial name
- NCT02420600
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cardiac Arrest (CA), Resuscitated Sudden Cardiac Death
Long Term Follow-up of Cardiac Arrest Survivors Exposed to Ultra-rapid Cooling
Less than 10% of patients eliciting out-of-hospital cardiac arrest (OHCA) survive, although 30% can be resuscitated by Emergency services before admission in Intensive Care Units (ICU).
- Conditions
- Cardiac Arrest (CA), Resuscitated Sudden Cardiac Death, Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
- Trial name
- AFTERCOOL (NCT07028372)
- Testing
- Short Form Health Survey (SF-36), Modified Rankin Score (mRS), Activity of Daily Living (ADL) questionnaire
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease, Acute Renal Failure
The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure
The purpose of this trial is to study the use of nesiritide in thoracic aneurysm repair to prevent acute renal failure. The study hypothesis: Nesiritide, given prophylactically prior to surgery may prevent acute renal failure…
- Conditions
- Cardiovascular Disease, Acute Renal Failure, Death
- Trial name
- NCT00110201
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Ejaz, Abulate A, MD
End-of-Life, Physical Suffering
Virtual Reality Therapy to Improve Physical and Psychological Symptoms and Quality of Life for End-of-life Patients on a Palliative Care Unit
People with advanced and life-threatening illnesses experience challenges across multiple domains of function including physical, psychological, social, and spiritual.
- Conditions
- End-of-Life, Physical Suffering, Psychological Distress
- Trial name
- NCT04966260
- Testing
- Standardized Virtual Reality, Control, Personalized Virtual Reality
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Baycrest
End of Life, Palliative Patients
IMPULS-NRW: Telemedicine in Specialized Outpatient Palliative Care
This study examines the feasibility, user-friendliness, and impact of digital support in outpatient palliative care. Patients, relatives, and professional caregivers use the web-based ISPC platform (information system for…
- Conditions
- End of Life, Palliative Patients, Outpatient Treatment
- Trial name
- IMPULS-NRW (NCT07491679)
- Testing
- IMPULS-NRW
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Dialysis, Quality of Life
Prognostic Determinants of Survival and Quality of Life in Prevalent End-stage Kidney Disease Patients
Patients with end-stage kidney disease are treated with dialysis to increase their life expectancy as well as their quality of life (QoL).
- Conditions
- Dialysis, Quality of Life, Nutrition
- Trial name
- NCT03910426
- Testing
- Blood sampling, Nails collection, Stool collection
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Brain Death
Validation of the Apnea Test Performed by High-flow Oxygen Therapy in Patients With Clinical Brain Death
Brain death is a clinical and paraclinical diagnosis established in a known etiological context. It involves the irreversible destruction of cerebral functions in a beating-heart individual.
- Trial name
- APNEAFLOW (NCT05950178)
- Testing
- Apnea test under high-flow oxygenation
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Neoplasms, Heart Failure
Preparing Family Caregivers to Make Medical Decisions for Their Loved Ones
The overarching goal of the project is to improve the process and experience of surrogate decision-making by family caregivers. Since feeling unprepared to make surrogate decisions is a major contributor to caregiver stress, the…
- Conditions
- Neoplasms, Heart Failure, Kidney Diseases, Lung Diseases
- Trial name
- NCT02429479
- Testing
- Making Your Wishes Known, Standard advance care planning
- Where
- 2 sites in United States
- Volunteers
- 285 people
- Sponsor
- Milton S. Hershey Medical Center
Chronic Kidney Disease, Chronic Renal Failure
Exploring the Impact of " ACP Board Game for Life" on Death Preparation and Anxiety in Patients With Stage 4 and 5 Chronic Kidney Diseases: A Pilot Study
This study was to explore the impacts of participating in "ACP board game for life" on death preparation, death anxiety, end-of-life care preferences, and intervention perception in stage 4-5 CKD patients with advanced chronic…
- Conditions
- Chronic Kidney Disease, Chronic Renal Failure, Chronic Renal Insufficiency, End of Life Care
- Trial name
- NCT06046261
- Testing
- ACP board game for life
- Where
- Taiwan
- Volunteers
- 69 people
- Sponsor
- National Cheng-Kung University Hospital
Triple Negative Breast Cancer
Stromal Tumor-Infiltrating Lymphocyte Levels Are Associated With Immune Checkpoint Proteins In Triple Negative Breast Cancer Patients Receiving Neoadjuvant Chemotherapy
The goal of this observational study is to learn about the effects of neoadjuvant chemotherapy (NACT) anthracycline-containing, taxane- (Intervention A +T) and anthracycline/taxane /carboplatin (Intervention A+T+C) treatment in…
- Trial name
- TIL; PD1; PDL1 (NCT06965361)
- Testing
- carboplatin
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Ziauddin University
Dyspnea
Palliative Oxygen for the Relief of Breathlessness
The main goal of this study is to establish the effectiveness of palliative oxygen in the context within which it is usually provided--relief of the sensation of breathlessness and improvement in quality of life for people with…
- Trial name
- NCT00327873
- Testing
- Oxygen, Medical Air
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 240 people
- Sponsor
- National Health and Medical Research Council, Australia
Drowning
Observational Study of Drowning Patient's Emergency Care in Its Pre-hospital Phase.
According to the 9th edition of "NOYADES" survey, 1480 drownings accidents occurred in France in 2021, of which 146 (i.e. nearly 10%), were in the Var department.
- Trial name
- VAR-NOYADE (NCT05751655)
- Testing
- Prehospital care following drowning accident
- Where
- France
- Volunteers
- 296 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Mucopolysaccharidosis II
Safety and Dose Ranging Study of Insulin Receptor MoAb-IDS Fusion Protein in Patients With Hunter Syndrome
AGT-182 is a fusion protein containing idursulfase that is intended to deliver the enzyme peripherally and to the brain, when administered intravenously.
- Trial name
- NCT02262338
- Testing
- AGT-182
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 6 people
- Sponsor
- ArmaGen, Inc
End Stage Renal Disease, Coronary Heart Disease
T Wave Alternans in Hemodialysis
The purpose of this study is to determine if the hemodialysis procedure changes the risk for cardiac arrest in patients.
- Conditions
- End Stage Renal Disease, Coronary Heart Disease, Congestive Heart Failure
- Trial name
- NCT00296543
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
End Stage Renal Disease
Events Before Death
Previous studies of the patients treated in RRI clinics suggest that hemodialysis patients undergo a certain consistent predictable pattern at the initiation of dialysis and before death.
- Trial name
- NCT01329055
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- Renal Research Institute
Rare Diseases, Fabry Disease
Evaluation of HEArt invoLvement in Patients With FABRY Disease
This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.
- Conditions
- Rare Diseases, Fabry Disease, Fabry Disease, Cardiac Variant, Hypertrophic Cardiomyopathy
- Trial name
- HEAL-FABRY (NCT03362164)
- Where
- Germany
- Volunteers
- 650 people
- Sponsor
- Wuerzburg University Hospital