Clinical trials: End of Life Patients
Restless Legs Syndrome, End Stage Renal Disease
Exercise Training in Dialysis Patients With Restless Legs Syndrome (RLS)
Uremic etiology Restless legs syndrome (RLS) has been associated with poorer quality of life (QoL) compared to RLS-free counterparts mainly due to sleep deprivation factors.
- Conditions
- Restless Legs Syndrome, End Stage Renal Disease, Hemodialysis, Muscle Cachexia
- Trial name
- HDRLS (NCT00942253)
- Testing
- Dopamine Agonist and Exercise
- Where
- Greece
- Volunteers
- 46 people
- Sponsor
- University of Thessaly
Venous Thromboembolism
Characterizing Recurrent Thromboembolism, Major Bleeding and All-Cause Death in Patients With Cancer-Associated Thromboembolism Treated With Rivaroxaban
To estimate the real-world rates of recurrent Venous thromboembolism (VTE), major bleeding and all-cause mortality in patients with Cancer-associated thrombosis (CAT) treated with rivaroxaban
- Trial name
- NCT03214172
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Bayer
Small-cell Lung Cancer, Neoadjuvant Therapy
Combined Atezolizumab and Chemotherapy (Carboplatin Plus Etoposide) in Neoadjuvant Treating Limited-Stage Small Cell Lung Cancer Patients
This Phase II study was designed to evaluate the safety and efficacy of Atezolizumab in combination with Chemotherapy compared with treatment with Chemotherapy alone in previously untreated Limited-Stage Small Cell Lung Cancer…
- Trial name
- NCT04696939
- Testing
- Atezolizumab, Carboplatin, Etoposide
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Postoperative Death
Descriptive and Risk Factors Analysis of All-cause Postoperative Death in Patients Undergoing Cardiovascular Surgery
The investigators are aimed to develop and externally validate a prediction model of clinical risk factors that quantifies postoperative death after cardiac and vascular surgery.
- Trial name
- NCT04926012
- Where
- 5 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Huazhong University of Science and Technology
Infant Mortality, Infant Death
Today Not Tomorrow Pregnancy and Infant Support Program (TNT- PISP)
This pilot project aims to implement and investigate the feasibility and acceptability of a unique community based prenatal care and support model for African American women and infants in Dane County.
- Conditions
- Infant Mortality, Infant Death, Racial Bias, Prenatal Stress
- Trial name
- NCT04100577
- Testing
- Today Not Tomorrrow Pregnancy and Infant Support Program
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Metastatic Colorectal Cancer
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
This randomized, multi-site, three-part study will test a new treatment called BNT314, which is designed to help the body's own defense to fight cancer in combination with another new treatment (pumitamig, which is a cancer…
- Trial name
- NCT07079631
- Testing
- BNT314, Pumitamig, SoC chemotherapy treatment 1
- Where
- 14 sites in United States, Germany and 3 more
- Volunteers
- 482 people
- Sponsor
- BioNTech SE
Brain Death
Implementation of Apnoea Test for Patients With Suspected Brain Death
This study consists of a survey created for intensive care physicians regarding their current practice of the implementation of apnoea test for patients with suspected brain death.
- Trial name
- NCT06359119
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Heart Failure, Sudden Death
MIBG Scintigraphy as a Tool for Selecting Patients Requiring Implantable Cardioverter Defibrillator (ICD)
The aim of the study is to assess the cardiac innervation in patients with heart failure to better select candidates for an implantable cardioverter defibrillator.
- Trial name
- MISTIC (NCT01185756)
- Testing
- MIBG for diagnostic purpose
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Solid Tumor
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) in Pediatric and Young Adult Participants With Solid Tumors
This early phase, multicenter, open-label, single-arm study evaluated the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary efficacy of atezolizumab in pediatric and young adult participants with solid…
- Trial name
- NCT02541604
- Testing
- Atezolizumab
- Where
- 30 sites in United States, Canada and 9 more
- Volunteers
- 87 people
- Sponsor
- Hoffmann-La Roche
Anemia
An Observational Study of Epoetin Beta [Neorecormon] to Evaluate the Quality of Life in Patients on Dialysis With Chronic Renal Anemia
This multicenter, prospective, observational study will evaluate the quality of life and the factors that influence the quality of life of epoetin beta [Neorecormon] in patients with renal chronic anemia, who are on dialysis.
- Trial name
- NCT01105494
- Testing
- epoetin beta [NeoRecormon]
- Where
- Morocco
- Volunteers
- 6,000 people
- Sponsor
- Hoffmann-La Roche
Advanced Cancer, Neoplasms
The "Hand-in-Hand Study": Improvement of Quality of Life in Palliative Cancer Patients Through Collaborative Advance Care Planning
This study evaluates the effect of a collaborative advance care planning intervention on the quality of life in palliative oncological patients.
- Conditions
- Advanced Cancer, Neoplasms, End Stage Cancer
- Trial name
- COLAP (NCT03387436)
- Testing
- Study-Intervention
- Where
- 2 sites in Germany
- Volunteers
- 280 people
- Sponsor
- PD. Dr. med. Carola Seifart
Peripheral Arterial Disease, Atherosclerosis of Extremities
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with…
- Conditions
- Peripheral Arterial Disease, Atherosclerosis of Extremities, Inflammation
- Trial name
- LEADER-PAD (NCT04774159)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- 86 sites in United States, Australia and 8 more
- Volunteers
- 6,150 people
- Sponsor
- Population Health Research Institute
Acute Decompensated Heart Failure, Congestive Heart Failure
Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart Failure
This study evaluated the effect of early initiation of aliskiren therapy, compared to standard therapy, in the reduction of cardiovascular death and heart failure re-hospitalization events within 6 months, in congestive heart…
- Trial name
- ASTRONAUT (NCT00894387)
- Testing
- Aliskiren
- Where
- 308 sites in United States, Argentina and 22 more
- Volunteers
- 1,639 people
- Sponsor
- Novartis Pharmaceuticals
Stress Disorders, Post-Traumatic, Tissue Donors
Evaluation of Post-traumatic Stress Among the Nearest Relatives of Brain-dead Organ Donors
The goal is to compare post tramautic stress between the nearest relatives of brain-dead patients who are organ donor to those of brain-dead patients who are not organ donors for medical, legal or opposition reasons.
- Conditions
- Stress Disorders, Post-Traumatic, Tissue Donors, Tissue and Organ Procurement
- Trial name
- NCT01214018
- Testing
- Questionnaires and interview
- Where
- 4 sites in France
- Volunteers
- 91 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cancer, Patients Living With Stage IV or Recurrent Cancer
Quality of Care for Adolescent and Young Adult (AYA) Patients Living With Serious or Advanced Cancer
Background: Cancer among adolescents and young adults (AYAs) is on the rise, with nearly 90,000 AYAs diagnosed in the US each year.
- Trial name
- NCT07484282
- Testing
- Quality Assessment
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Bypass, Myocardial Reperfusion Injur
Remote Ischemic Conditioning to Attenuate Myocardial Death and Improve Operative Outcome.
This study evaluates the addition of remote ischemic preconditioning and postconditioning to standard myocardial protection protocol in patients submitted to off - pump coronary artery bypass grafting in a prospective, 1:1…
- Conditions
- Coronary Artery Bypass, Myocardial Reperfusion Injur, Ischemic Preconditioning, Myocardial, Ischemic Postconditioning
- Trial name
- RICARDO (NCT03363958)
- Testing
- Remote Ischemic Preconditioning with Postconditioning
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medinet Heart Centre
Non Small Cell Lung Cancer, Influenza Vaccine
Impact of Inactivated Trivalent Influenza Vaccine on NSCLC Patients Receiving PD-1 / PD-L1 Inhibitors
This project is to assess the immunogenicity, safety and overall survival impact of intramuscular injection of trivalent influenza vaccine in non-small cell lung cancer (NSCLC) patients with PD-1/PD-L1 inhibitor treatment.
- Trial name
- NCT04355806
- Testing
- PD-1/PD-L1 inhibitors, Inactivated trivalent influenza vaccine
- Where
- 2 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Support, Family
The Effect of Psychoeducation on Hopelessness, Death Anxiety and Caregiver Burden
This study was conducted to determine the effect of Watson Human Caring Model-based psychoeducation given to the relatives of patients receiving palliative care on hopelessness, death anxiety and the burden of care.
- Trial name
- NCT06154759
- Testing
- Watson Human Caring Model-based psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara Medipol University
Palliative Care
Advance Care Planning in Palliative Care
The question of the end of life is a major public health issue. In the field of palliative care, the notion of anticipation is central for people with a serious and progressive illness.
- Trial name
- ANTICIPALL (NCT05662917)
- Testing
- Individual semi-structured interviews
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon