Clinical trials: End of Life Patients
Glaucoma
Does Using a Low Vision Aid Device Improve Quality of Life in Glaucoma Patients?
To determine the impact of OrCam over 1 month on health-related quality of life (HRQoL) in subjects with advanced glaucoma using the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ-25).
- Trial name
- NCT02526680
- Testing
- OrCam
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Wills Eye
Chronic Kidney Diseases, Kidney Failure, Chronic
Decision Aid for Renal Therapy
Good communication among patients, their families and loved ones, and their medical care providers is important when figuring out how to treat chronic diseases like kidney disease.
- Trial name
- DART (NCT03522740)
- Testing
- Decision Aid for Renal Therapy
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Tufts University
Non Small Cell Lung Cancer NSCLC
Study of Durvalumab + Tremelimumab With Chemotherapy or Durvalumab With Chemotherapy or Chemotherapy Alone for Patients With Lung Cancer (POSEIDON).
This is a randomized, open-label, multi-center, global, Phase III study to determine the efficacy and safety of durvalumab + tremelimumab combination therapy + Standard of care (SoC) chemotherapy or durvalumab monotherapy + SoC…
- Trial name
- POSEIDON (NCT03164616)
- Testing
- Durvalumab, Tremelimumab, Abraxane + carboplatin
- Where
- 175 sites in United States, Brazil and 17 more
- Volunteers
- 1,186 people
- Sponsor
- AstraZeneca
Postoperative Complications, Emotion Regulation
The Effect of Emotional Freedom Techniques Application on Patients With Cancer Phobia
The aim is to examine the effect of Emotional Freedom Technique on death anxiety in patients with postoperative cancer phobia. The hypotheses of the study are as follows: H0: Emotional Freedom Technique has no effect on…
- Conditions
- Postoperative Complications, Emotion Regulation, Death Anxiety
- Trial name
- NCT06816576
- Testing
- Emotional Freedom Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Bitlis Eren University
Breast Cancer, Triple Negative Breast Cancer
Abraxane With or Without Tigatuzumab in Patients With Metastatic, Triple Negative Breast Cancer
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer deaths in American women. Metastatic disease including metastatic breast cancer unfortunately remains incurable.
- Conditions
- Breast Cancer, Triple Negative Breast Cancer, Stage IV Breast Cancer, Metastatic Breast Cancer
- Trial name
- NCT01307891
- Testing
- Abraxane alone, Abraxane + Tigatuzumab
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Dementia, Alzheimer, Electronic Health Records, Hospitalizations, Epidemiology, Comorbidity, United Kingdom, Incidence, Mortality, Cause of Death
Natural History and Patient Journey in Dementia: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.
The trajectory of dementia patients within the national health system and their recent temporal trends remains to be fully elucidated.
- Trial name
- NCT04321486
- Testing
- The study does not have an intervention, but observe the dementia incidence of the UK disease-free population.
- Volunteers
- 4,309,481 people, healthy volunteers welcome
- Sponsor
- University College, London
HCM - Hypertrophic Cardiomyopathy, S-ICD System (implantable Defibrillator)
An Observational Study of Subcutaneous Implantable Cardioverter Defibrillator in Patients with Hypertrophic Cardiomyopathy At High Risk of Sudden Cardiac Death
1. To observe the failure rate of S-ICD screening in HCM patients at high risk of SCD. 2. To observe the incidence of IAS in HCM patients with S-ICD implantation and explore the related factors of IAS.
- Trial name
- NCT06604169
- Where
- China
- Volunteers
- 589 people
- Sponsor
- China National Center for Cardiovascular Diseases
Recurrent/ Advanced Stage Endometrial Cancer Patients
An Open-label, Single Arm, Phase II Trial of Niraparib in Combination With Anti-PD1（Programmed Cell Death Protein 1） Antibody in Recurrent/ Advanced Stage Endometrial Cancer Patients
Endometrial carcinoma is the most common malignancy of the female reproductive tract. Most cases are diagnosed at an early stage due to the appearance of symptoms such as postmenopausal bleeding.
- Trial name
- NCT04885413
- Testing
- Niraparib in Combination With Anti-PD1 Antibody
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Sun Yat-sen University
Health Care Utilization, End Stage Disease
ACP Video Intervention for Patients With Life-Limiting Illness
The goal of this research is to increase patients' knowledge about advance care planning (ACP) discussions and hospice care for patients with serious illness receiving home-based care.
- Trial name
- NCT04778761
- Testing
- Home ACP Video
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Brain Death
Electrical Impedance Tomography Measurements During Apnea Test in Patients With Suspected Brain Death
Apnea testing is the final decisive examination in the strictly regulated process of brain death assessment. There is no standardized method found in the literature for apnea testing except for the inspection of possible…
- Trial name
- NCT04857242
- Testing
- Apnea test, alveolar recruitment
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Kiskunhalas Semmelweis Hospital the Teaching Hospital of the University of Szeged
Oral Mucositis, Quality of Life
Effect of a Novel Topical Composition on the Incidence of Severe Oral Mucositis in Head & Neck Cancer Radiated Patients and Quality of Life Assessed by PROMs.
The use of a novel topical mucosa composition (XCM-OM118) comprising 2-(trimethylazaniumyl) acetate; (2R,3R,4S)-pentane-1,2,3,4,5-pentol; Hexadecanoic acid; (9Z, 12Z)-octadeca-9,12-dienoic acid; octadecanoic acid…
- Conditions
- Oral Mucositis, Quality of Life, Mucositis, Pain
- Trial name
- STOPOMP (NCT05635929)
- Testing
- XCM-OM118 Composition comprising olive oil, betaine and xylitol
- Where
- Spain
- Volunteers
- 63 people
- Sponsor
- Mucosa Innovations, S.L.
SUDEP, Epilepsy
Improving Patient Communication About SUDEP
Children with generalized tonic-clonic seizures (GTCS) have about a 1 in 4500 of succumbing to sudden unexpected death in epilepsy (SUDEP).
- Trial name
- NCT03502759
- Testing
- CHICA SUDEP module
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Indiana University
End of Life Care, Liver Cirrhosis
Palliative Care for Patients With Liver Cirrhosis
Background: Patients with liver cirrhosis rarely receive palliative care although the Danish Health Authorities and WHO recommend it.
- Conditions
- End of Life Care, Liver Cirrhosis, Nurse-Patient Relations, Quality of Life
- Trial name
- LiverCare (NCT05431946)
- Testing
- Advance Care Planning and the consequent actions
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
The Families or Next of Kin of Patients Treated at MSKCC for Non-cutaneous Squamous Cell Carcinomas of the, Upper Aerodigestive Tract
Improving End of Life Care in Head and Neck Cancer
The purpose of this study is to improve the quality of care provided for head and neck cancer patients. By better understanding the end of life experiences of dying patients and their families, the investigators hope to better…
- Trial name
- NCT01632969
- Testing
- The The Family Assessment of Treatment at the End of life (FATE ) survey
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Emotional Stress, Psychological Distress
Dignity Therapy for Terminally Ill Patients: A Randomized Controlled Trial
We conducted a randomized, controlled trial of dignity therapy for terminally ill patients with the aim of reducing dignity-related distress and demoralization and improving spiritual well-being.
- Conditions
- Emotional Stress, Psychological Distress, Death, Dignity
- Trial name
- NCT04256239
- Testing
- Dignity Therapy
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- European University of Rome
Myocardial Infarction, Heart Failure
A Critical Pathway for Implantable Cardioverter-Defibrillators in Patients With Ischemic Cardiomyopathy
The purpose of this study is to develop and implement a critical pathway to identify patients with ischemic cardiomyopathy who are candidates for an implantable cardioverter-defibrillator (ICD).
- Trial name
- CAPTURE (NCT01248702)
- Testing
- Use of the ICD Critical Pathway
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- University of British Columbia
Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer
Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer
This pilot clinical trial studies low-dose acetylsalicylic acid in treating patients with stage I-III non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Recurrent Non-small Cell Lung Cancer, Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
- Trial name
- NCT01707823
- Testing
- acetylsalicylic acid, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
ESRD (End Stage Renal Disease), Dialysis
Laser Acupuncture for Fatigue in Hemodialysis Patients
The goal of this clinical trial is to learn if laser acupuncture (low-level laser therapy) works to treat fatigue and improve quality of life in adults with end-stage renal disease (ESRD) undergoing hemodialysis.
- Conditions
- ESRD (End Stage Renal Disease), Dialysis, Fatigue
- Trial name
- LA-HD-Fatigue (NCT07538310)
- Testing
- Low-Level Laser Acupuncture (LA)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Taipei City Hospital
Advanced Chronic Liver Disease, Urinary Infection
The INFECIR-2 Albumin Prevention Study
The aim of this study is to evaluate whether albumin administration improves short-term survival in patients with advanced cirrhosis and bacterial infections other than Spontaneous Bacterial Peritonitis (SBP).
- Conditions
- Advanced Chronic Liver Disease, Urinary Infection, Pneumonia, Cholangitis
- Trial name
- INFECIR2 (NCT02034279)
- Testing
- Albumin
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- EASL - CLIF Consortium
Acute Myocardial Infarction, Congestive Heart Failure
Nicorandil Study to Reduce Cardiac Death After Percutaneous Coronary Intervention (PCI) in Hemodialysis Patients
Survival after invasive coronary revascularization is worse in patients with chronic kidney disease than in those without it. The investigators aimed to examine whether oral administration of nicorandil, a hybrid of nitrate and…
- Trial name
- NCT00848562
- Testing
- Nicorandil
- Where
- Japan
- Volunteers
- 129 people
- Sponsor
- Toujinkai Hospital