Clinical trials: End of Life Patients
Implantable Defibrillator User, Terminal Illness
GAMification to Encourage End-Of-Life Discussions Between ICD Patients and Caregivers
The purpose of this study is to determine the feasibility and efficacy of the GAMification to Encourage End-Of-Life (GAME-EOL) intervention, which uses the Hello Game program to encourage and facilitate quality end-of-life (EOL)…
- Trial name
- GAME-EOL (NCT04994782)
- Testing
- GAME-EOL
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Debra Moser
Anesthesia
Expired Propofol in Low Back Surgery
Edmon (BBraun, Germany) is a portable, commercially available device for measurement of propofol in exhaled air. The study will aim at evaluating the sensitivity and specificity of such exhaled propofol values compared with…
- Trial name
- NCT04771702
- Testing
- Edmon
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Mitral Annular Disjunction, Mitral Valve
Loop Recorder Implantation in Patients With Mitral Annular Disjunction
The goal of clinical trial is to prospectively collect data to investigate the prevalence of arrhythmia in young patients diagnosed with mitral annular disjunction who have no indication for implantable cardioverter defibrillator…
- Conditions
- Mitral Annular Disjunction, Mitral Valve, Arrhythmia Ventricular, Sudden Cardiac Death Due to Cardiac Arrhythmia
- Trial name
- ILR MAD IIT (NCT07436962)
- Testing
- loop recorder implantation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Refractory Metastatic Colorectal Cancer
A Study Evaluating TAS-102 Plus Nivolumab in Patients With MSS CRC
A Phase 2 Study with Safety Lead-in, Evaluating TAS-102 Plus Nivolumab in Participants with Microsatellite Stable Refractory Metastatic Colorectal Cancer
- Trial name
- NCT02860546
- Testing
- TAS-102, nivolumab
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Taiho Oncology, Inc.
Ischemia, Coronary Artery Disease
A Pilot First In Man Study of EXCEL-Ⅱto Treat the Patients With de Novo Coronary Artery Lesions
One of the purpose of this study is to assess the preliminary safety and feasibility,and to provide related information and evidence for the design of the further pivotal randomized control trial.the other purpose is to assess…
- Trial name
- CREDIT (NCT01909869)
- Testing
- EXCEL-Ⅱ
- Where
- China
- Volunteers
- 45 people
- Sponsor
- JW Medical Systems Ltd
Acute Respiratory Distress Syndrome, Capnography
Dead Space Monitoring With Volumetric Capnography in ARDS Patients
This studies´ objective is to describe how different PEEP levels affect dead space measured by Bohr´s formula.
- Trial name
- NCT02889770
- Testing
- PEEP titration
- Volunteers
- 10 people
- Sponsor
- Hospital Italiano de Buenos Aires
COVID-19
Minimal Invasive Autopsies to Investigate Changes in Deceased COVID-19 Patients
Rationale In a very short time corona virus disease 2019 (COVID-19) has become a pandemic with high morbidity and mortality. The main cause of death is respiratory failure including acute respiratory distress syndrome, however…
- Trial name
- MIA-COVID-19 (NCT04366882)
- Testing
- CT-scan with minimal invasive autopsy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Jessa Hospital
Sensorineural Hearing Loss, Bilateral, Cochlear Hearing Loss
Non-linear Frequency Compared to Conventional Processing in Patients With and Without Cochlear Dead Regions.
The investigators are interested in an additional hearing aid feature called non-linear frequency compression (NLFC). This aims to improve audibility of high frequency sounds by converting them into lower frequencies and has been…
- Trial name
- NCT04145661
- Testing
- Hearing aids programmed conventionally., Hearing aids programmed with compression activated.
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Death, Stroke
Postoperative Atrial Fibrillation and Long-term Survival
The aim of the investigators trial was to evaluate association between new onset postoperative atrial fibrillation (POAF) and late cardiovascular morbidity and mortality.
- Conditions
- Death, Stroke, Myocardial Infarction
- Trial name
- POAF (NCT02349269)
- Volunteers
- 519 people, healthy volunteers welcome
- Sponsor
- Kuopio University Hospital
Cutaneous Melanoma
Expression of IL4 Induced Gene 1 in Patients With Cutaneous Melanoma: Value in Prognosis and/or in Predictive Response to Immune Checkpoint Inhibitors
To characterize and quantify immune cells expressing the Interleukine 4 induced gene 1 (IL4I1) immunosuppressive enzyme in the blood and in tissue of melanoma patients (primary tumor, sentinel lymph nodes and cutaneous…
- Trial name
- ENZYMELA (NCT04253080)
- Testing
- Blood sample, Cutaneous melanoma biopsy
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertrophic Cardiomyopathy
3D Non-invasive Myocardial Electrical Propagation Mapping as a New Tool to Predict Sudden Death Risk in Patients With Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is very common. The thickened heart muscle can disrupt the normal functioning of the heart's electrical system, resulting in fast or irregular heartbeats.
- Trial name
- 3D-CMH (NCT03550573)
- Testing
- CardioInsight™ Noninvasive 3D Mapping System
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Heart Failure, Branch Block, Bundle
DANISH-CRT - Does Electric Targeted LV Lead Positioning Improve Outcome in Patients With Heart Failure and Prolonged QRS
Heart failure is a leading cause of morbidity and mortality. Cardiac resynchronization therapy (CRT) is a well-established treatment for patients with symptomatic heart failure in spite of optimised medical treatment (OMT)…
- Trial name
- NCT03280862
- Testing
- Implantation of a Cardiac Resynchronisation Therapy (CRT) pacing device with or without Implanted Cardioverter Defibrillator
- Where
- 5 sites in Denmark
- Volunteers
- 1,000 people
- Sponsor
- Aarhus University Hospital
Longitudinal Studies, Prospective Studies
Clinical Time and Temporal Dynamics Study (CLIN-TIME)
TH-CLINICAL-TIME is a prospective, longitudinal observational study evaluating how changes in clinical measurements over time may help researchers better understand patient health trajectories and clinically meaningful outcomes.
- Conditions
- Longitudinal Studies, Prospective Studies, Biomarkers, Predictive Value of Tests
- Trial name
- CLIN-TIME (NCT07812831)
- Testing
- No Study-Assigned Intervention
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Sudden Cardiac Death, Heart Failure
Educational Videos to Address Racial Disparities in Implantable Cardioverter Defibrillator Therapy
VIVID is a prospective, multicenter, randomized clinical trial in African American patients that will to evaluate: (1) the effect of an educational video on knowledge of sudden cardiac death (SCD) and implantable cardioverter…
- Trial name
- VIVID (NCT02819973)
- Testing
- Educational Video1, Educational Video 2, Usual Care 3
- Where
- 14 sites in United States
- Volunteers
- 343 people
- Sponsor
- Duke University
Advanced Cancer
Study of Palliative Care Intervention for Advanced Cancer Patients and Their Caregivers -Educate Nurture Advise Before Life Ends (ENABLE III)
ENABLE III is a randomized clinical trial that evaluates a phone-based palliative care intervention designed to improve quality of life, mood, and symptom management for patients with an advanced stage cancer and their…
- Trial name
- ENABLE III (NCT01245621)
- Testing
- Later entry group, Early palliative care intervention
- Where
- 7 sites in United States
- Volunteers
- 360 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Brain Death
The Anticipated Organ Donation Approach
The purpose of this study is to make a paramedical evaluation of a selection procedure of serious brain-injured patient in therapeutic abstention to a brain death state within 48 hours.
- Trial name
- PREMORENCE (NCT03765814)
- Where
- 4 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
End Stage Kidney Disease (ESKD)
Acupuncture for Symptom Burden and Quality of Life in Patients With End-Stage Kidney Disease
Patients with end-stage kidney disease (ESKD) undergoing hemodialysis or peritoneal dialysis experience a high burden of symptoms, including fatigue, pain, pruritus, muscle cramps, and sleep disturbances, which substantially…
- Trial name
- Acup-ESKD (NCT07887607)
- Testing
- Acupuncture
- Where
- Greece
- Volunteers
- 160 people
- Sponsor
- University General Hospital of Heraklion
Cardiovascular Diseases
A Study of Sleep Patterns to Determine Predictive Markers Due to Cardiovascular Disease in Elderly Patients
The purpose of this study is to learn if there are predictive markers of hospitalization or death that can be found from data gathered from a Sleep Number® bed.
- Trial name
- NCT05749263
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Mayo Clinic
Nutrition Aspect of Cancer, End Stage Cancer
Efficacy of Parenteral Nutrition in Patients at the Palliative Phase of Cancer.
In malnourished patients in the palliative phase of cancer, the question is raised of the relevance of implementing artificial nutritional assistance instead of oral feeding when this is possible.
- Trial name
- ALIM-K (NCT02151214)
- Testing
- Parenteral nutrition
- Where
- 13 sites in France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sepsis
The Study of Drotrecogin Alfa (Activated) in Adult Patients With Severe Sepsis at a Low Risk of Death
Adult Patients with Severe Sepsis
- Trial name
- NCT00568737
- Testing
- Drotrecogin alfa (activated)
- Where
- 70 sites in Argentina, Australia and 10 more
- Volunteers
- 2,640 people
- Sponsor
- Eli Lilly and Company