Clinical trials: End-Stage Kidney Disease
Physical Activity, End Stage Kidney Disease
The "Step4Life" Randomized Control Trial in Hemodialysis
Persons with end-stage kidney disease (ESKD) have very low physical activity, and among ESKD patients, the level of inactivity is strongly associated with morbidity and mortality.
- Conditions
- Physical Activity, End Stage Kidney Disease, Hemodialysis
- Trial name
- NCT05241171
- Testing
- Fitbit
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, San Diego
End Stage Renal Disease (ESRD)
Product Evaluation for the Effectiveness of the ClearGuard™ HD End Cap
To assess positive blood cultures (PBCs) in hemodialysis central venous catheter (CVC) patients using two FDA cleared devices: ClearGuard HD end caps compared to conventional end caps.
- Trial name
- NCT02604264
- Testing
- ClearGuard HD end cap
- Where
- United States
- Volunteers
- 2,912 people
- Sponsor
- Pursuit Vascular, Inc.
Bladder Cancer, Prostate Cancer
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
This study will evaluate the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Bladder Cancer, Prostate Cancer, Kidney Cancer, Pelvic Tumor
- Trial name
- NCT05696444
- Testing
- RAS Prostatectomy, RAS Cystectomy, RAS Nephrectomy
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Medtronic - MITG
Hemodialysis Complication
Impact of Hemodialysis on Plasma Carnitine Levels in Patients With End Stage Renal Disease
OBJECTIVES To assess the levels of plasma carnitine in controls and hemodialysis patients. To give supplementary L-carnitine to study subjects for a duration of 5months.
- Trial name
- NCT05817799
- Testing
- L-Carnitine 500Mg thrice daily, 1g L-Carnitine IV three times a week
- Where
- Pakistan
- Volunteers
- 83 people
- Sponsor
- Bahria University
Renal Failure Chronic
Immunotherapy of Chronic Kidney Failure
Kidney failure can result from inflammatory renal disease in the context of autoimmunity because the kidney is targeted by host's immune response against self.
- Trial name
- NCT04377243
- Testing
- V8
- Where
- Mongolia
- Volunteers
- 20 people
- Sponsor
- Immunitor LLC
End-Stage Renal Disease, End-Stage Kidney Disease
A Study of MK-2060 in Participants With Chronic and/or End-Stage Kidney Disease (MK-2060-011)
This was intended as a three-part study of MK-2060 in participants with chronic and/or end-stage kidney disease (Parts 2 and 3 were not initiated due to reasons not related to safety).
- Conditions
- End-Stage Renal Disease, End-Stage Kidney Disease, Kidney Failure, Chronic
- Trial name
- NCT05656040
- Testing
- MK-2060
- Where
- 4 sites in United States
- Volunteers
- 14 people
- Sponsor
- Merck Sharp & Dohme LLC
End Stage Renal Disease (ESRD), CKD 5D, Hemodialysis
Activated Charcoal Use in Chronic Kidney Disease Patients
Hyperphosphatemia management is initially based on restricting dietary phosphorus intake. Hyperphosphatemia is almost always seen in patients on dialysis and may contribute to progressive vascular calcification.
- Conditions
- End Stage Renal Disease (ESRD), CKD 5D, Hemodialysis, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder
- Trial name
- NCT06906874
- Testing
- Activated Charcoal, Phosphate Binders
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Chronic Kidney Diseases, Haemodialysis
Live Classical Music and the Response to the Disease and Its Evolution in Patients With Chronic Renal Failure
People are most vulnerable to anxiety when faced with life-threatening situations such as illness, medical treatments and surgeries.
- Trial name
- NCT05729997
- Testing
- Listening to live classical music
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitario La Fe
Renal Dialysis
End-stage Renal Disease (ESRD) Pilot Study
The purpose of this study is to investigate the safety of two different doses of a drug called BAY1213790 and how well it is tolerated in patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD).
- Trial name
- NCT03787368
- Testing
- BAY1213790, 0.9% sodium chloride solution
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 55 people
- Sponsor
- Bayer
Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus
Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation
This study will be a prospective, single center, randomized controlled parallel group open-label trial. Participants with insulin requiring diabetes mellitus who have been offered an organ for living or deceased donor kidney…
- Conditions
- Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus, End Stage Renal Disease (ESRD)
- Trial name
- NCT04189510
- Testing
- Artificial Pancreas, Multiple Daily Injections
- Sponsor
- University of Virginia
Renal Failure
Pilot Study of Wearable Artificial Kidney
This is a pilot study of a wearable type of kidney dialysis machine to treat patients with chronic kidney disease.
- Trial name
- WAK (NCT00454974)
- Testing
- Wearable artificial kidney
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Free Hampstead NHS Trust
Chronic Renal Failure
Post-Marketing Surveillance on Long-Term Drug Use of Kiklin (Bixalomer)® Capsules in Patients With Hyperphosphatemia Receiving Peritoneal Dialysis
To evaluate the safety and efficacy of long-term use of Kiklin® Capsules in actual clinical settings.
- Trial name
- NCT01903213
- Testing
- bixalomer
- Where
- 8 sites in Japan
- Volunteers
- 123 people
- Sponsor
- Astellas Pharma Inc
Coronary Artery Disease, Myocardial Infarction
Imaging Modalities in Detection of Coronary Artery Disease in End-stage Renal Disease Patients
This study investigates hypothesizes that the combination of dobutamine stress echocardiography with dobutamine stress echocardiography with real time perfusion myocardial contrast echocardiography and coronary computed…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Stroke, Death
- Trial name
- NCT00726921
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- University of Nebraska
End-Stage Renal Disease
Vitamin D3 Supplementation in Dialysis Patients
Vitamin D deficiency is highly prevalent among dialysis patients, and has been associated with cardiovascular risk factors such as increased aortic pulse wave velocity, blood pressure, inflammation, and brain natriuretic peptide.
- Trial name
- NCT01312714
- Testing
- Cholecalciferol
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Regional Hospital Holstebro
Chronic Renal Failure
Soluble CD146 and Proteinuria in Chronic Renal Disease
Chronic renal disease (CKD) is defined as a decrease in glomerular filtration rate (GFR) and / or proteinuria or albuminuria (a protein present in urine). Albuminuria is considered a marker of endothelial dysfunction.
- Trial name
- CPinMRC (NCT03341949)
- Testing
- Recurring blood sample
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
End-stage Renal Disease, Hemodialysis
The Relationship Between Aortic Pulse Wave and Peripheral Artery Occlusion Disease in Hemodialysis Patients
Cardiovascular disease (CVD) is the leading cause of mortality in patients with end-stage renal disease (ESRD), which means that it is important to find out risk factors of CVD in order to prevent or treat it.
- Conditions
- End-stage Renal Disease, Hemodialysis, Aortic Calcification, Peripheral Artery Occlusion
- Trial name
- NCT01945255
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplant, End Stage Kidney Disease (ESRD)
ABO- or HLA- Incompatible LDKT Compared to Waitlist/DDKT in Elderly Patients
This retrospective multicenter cohort study evaluates the survival outcomes of elderly patients (aged ≥60 years) with end-stage kidney disease who underwent ABO- or HLA-incompatible living donor kidney transplantation compared…
- Trial name
- NCT07436338
- Where
- 2 sites in South Korea
- Volunteers
- 1,819 people
- Sponsor
- Seoul National University Hospital
End Stage Renal Disease
The Effect of Oxygen on Healing an Artery From the "Injury" of Surgery
Many grafts placed for dialysis access fail which causes patients to undergo additional operations, decreases their quality of life, and increases health care costs.
- Trial name
- NCT00863603
- Testing
- oxygen
- Where
- 3 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of Minnesota
Hyperparathyroidism, Secondary, Kidney Failure, Chronic
How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis
Patients with chronic kidney disease and end stage renal disease have greater cardiovascular risk than the general population. Vitamin D analogues have been shown in observational studies to have mortality benefit for these…
- Trial name
- NCT00528788
- Testing
- doxercalciferol
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Renal Impairment
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease
This study will be conducted to assess the safety and pharmacokinetics of INCB123667 when administered orally to adult participants with severe renal impairment or end stage renal disease.
- Trial name
- NCT07559396
- Testing
- INCB123667
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Incyte Corporation
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