Clinical trials: End-Stage Kidney Disease
Acute Renal Failure, Chronic Kidney Failure
The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.
- Conditions
- Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)
- Trial name
- NCT00358306
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hemodialysis, Ventriculo-arterial Coupling
Ventriculo-Arterial Coupling and Intra-Dialytic Changes in Hemodialysis Patients: Prognostic Insights
The acute effect of hemodialysis (HD) on left ventricular mechanics has been evaluated in several studies, however their results are not uniform.
- Trial name
- NCT06622928
- Testing
- Echocardiogram
- Where
- Kazakhstan
- Volunteers
- 384 people
- Sponsor
- Nazarbayev University
End Stage Renal Disease, Restless Legs Syndrome
DIalysis Symptom COntrol-Restless Legs Syndrome Trial
The DISCO-RLS Trial is a randomized controlled trial to determine the safety and efficacy of pharmacologic therapy (ropinirole versus placebo and gabapentin versus placebo) for the treatment of Restless Legs Syndrome in patients…
- Trial name
- DISCO-RLS (NCT03806530)
- Testing
- Gabapentin, Ropinirole
- Where
- 3 sites in Canada
- Volunteers
- 52 people
- Sponsor
- Population Health Research Institute
Chronic Renal Failure
Evluation of Thyroid Functions in Hemodialysis Childern in Sohag University Hospital
Thyroid gland and its hormones play an important role in organ development and the homeostatic control of many physiological mechanisms such as body growth and energy expenditure.
- Trial name
- NCT05451472
- Testing
- thyroid function tests, complete blood count, serum creatinine
- Volunteers
- 39 people
- Sponsor
- Sohag University
Chronic Kidney Disease, Renal Anemia
A Study of Roxadustat to Treat Anemia in Children and Teenagers With Chronic Kidney Disease
Roxadustat is a licensed medicine to treat anemia in adults with chronic kidney disease (CKD). Anemia is a low level of red blood cells.
- Trial name
- NCT05970172
- Testing
- Roxadustat
- Where
- 47 sites in Belgium, Croatia and 17 more
- Volunteers
- 98 people
- Sponsor
- Astellas Pharma Global Development, Inc.
End Stage Renal Disease
The Desensitization Therapy With GB-0998 for Anti-donor Antibody-positive Recipients.
It is intended to examine the safety and efficacy of desensitization therapy by GB-0998 (intravenous immunoglobulin) for the anti-donor antibody positive recipient in need of pre-transplant desensitization.
- Trial name
- NCT02032095
- Testing
- GB-0998
- Where
- Japan
- Volunteers
- 17 people
- Sponsor
- Japan Blood Products Organization
Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
Improving Medication Safety for Kidney Disease With a Digital Drug Dosing Tool in Nova Scotia Community Pharmacy Practice.
Chronic kidney disease (CKD) is a common condition. It occurs in approximately 7 out of 100 Canadians and is highest in rural settings. The kidneys are responsible for the removal of many drugs from the body.
- Trial name
- NCT06820372
- Testing
- Electronic Drug Dosing and Decision Support Kidney (eDoseCKD) Tool
- Volunteers
- 125 people
- Sponsor
- Nova Scotia Health Authority
End-stage Renal Disease, Chronic Kidney Diseases
Increasing Live Donor Kidney Transplantation Through Video-based Education and Mobile Communication
The study is a- 2-arm randomized controlled trial among patients presenting for kidney transplant evaluation at a single transplant center to compare the effects of a patient-based self-learning and outreach intervention about…
- Trial name
- KidneyTIME (NCT05154773)
- Testing
- Kidney donation and transplant information made easy
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- State University of New York at Buffalo
Kidney Disease, End-Stage, Kidney Transplant
Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal Transplantation
Renal transplantation is the most effective renal replacement therapy for patients with end-stage renal disease. Ischemia-reperfusion injury may adversely affect graft function and long-term outcomes.
- Conditions
- Kidney Disease, End-Stage, Kidney Transplant, Kidney, Kidney Disease
- Trial name
- NCT07678073
- Testing
- Sevoflurane General Anesthesia, Bupivacaine and Morphine for Combined Spinal-Epidural Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- University of Gaziantep
Chronic Kidney Disease, Inflammation
Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition in Japan.
The purpose of this research study is to compare the safety and effectiveness of 2 different doses of a study drug called ziltivekimab to placebo (an inactive substance) in reducing inflammation and improving some of the bad…
- Conditions
- Chronic Kidney Disease, Inflammation, Cardiovascular Risk
- Trial name
- RESCUE-2 (NCT04626505)
- Testing
- Ziltivekimab
- Where
- Japan
- Volunteers
- 36 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Disease, Hemodialysis
Low Sirtuin-1 Levels Are Linked to Erythropoietin Resistance in Hemodialysis Patients.
This study investigates the relationship between Sirtuin-1 (SIRT1) levels and erythropoietin resistance in hemodialysis patients.
- Conditions
- Chronic Kidney Disease, Hemodialysis, Anemia in End Stage Renal Disease, Erythropoietin
- Trial name
- NCT06877286
- Testing
- Sirtuin-1 Level Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 391 people
- Sponsor
- Cuma Bulent Gul
Chronic Kidney Failure, End Stage Renal Disease
Immune Development in Pediatric Transplantation (IMPACT)
Transplantation is the preferred method of treatment for end-stage renal disease (ESRD) in children. Over the past forty years, the use of newer immunosuppressive drugs has decreased the risk for organ rejection considerably, and…
- Trial name
- NCT00951353
- Where
- 3 sites in United States
- Volunteers
- 125 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemodialysis, End Stage Renal Disease
Comparative Effects of Milk Thistle Extract With Vitamin-E in Hemodialysis Patients
For end-stage renal disease (ESRD) patients, cardiovascular disease remains the single most common cause of excess morbidity and mortality.
- Trial name
- NCT01001845
- Testing
- Milk Thistle extract, vit E, vit E + Milk Thistle extract
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Shiraz University of Medical Sciences
Arteriovenous Graft Thrombosis, End Stage Renal Disease on Dialysis
Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis
Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood…
- Trial name
- NCT07613632
- Testing
- Electrical Impedance Tomography (EIT) Monitoring
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Hemodialysis
Hemodialysis-Induced Blood Pressure Change In End-Stage Renal Disease
Cardiovascular events are still the leading cause of mortality and morbidity in patients with ESRD including hemodialysis patients .
- Trial name
- Hemodialysis (NCT04933006)
- Testing
- Pulsevelocity
- Where
- Iran
- Volunteers
- 52 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
End Stage Renal Disease
A Simplified Lung Ultrasound Guided Management Protocol Of Pulmonary Congestion in Hemodialysis
Pulmonary congestion secondary to volume overload or interstitial tissue inflammation is common in chronic hemodialysis patients.
- Trial name
- NCT06296160
- Testing
- Intervention Group
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Hamad Medical Corporation
Renal Failure
Exercise in Patients With End Stage Kidney Disease
This study will be conducted over a 3 year time period. This is a trial of an exercise intervention vs. standard of care in patients receiving chronic dialysis.
- Trial name
- NCT03787589
- Testing
- Exercise Prescription
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Ottawa Hospital Research Institute
End Stage Renal Disease
Quality of Life on Peritoneal Dialysis Versus Hemodialysis in China
This is a multicenter, randomized, open-label study to compare QoL in subjects with end-stage renal disease (ESRD) requiring PD or conventional in-center HD treatment.
- Trial name
- NCT02378350
- Testing
- Hemodialysis treatment (no specific device is defined), Peritoneal Dialysis treatment (no specific drug is defined)
- Where
- 21 sites in China
- Volunteers
- 668 people
- Sponsor
- Vantive Health LLC
End-Stage Renal Disease, Kidney Transplantation
A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
The purpose of this study is to compare treatment with the new drug sirolimus (SRL) versus the standard treatment with cyclosporine (CsA) or tacrolimus in children who have received kidney transplants.
- Trial name
- NCT00005113
- Testing
- Cyclosporine, Sirolimus, Tacrolimus
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Boston Children's Hospital
Staphylococcal Infections, Chronic Kidney Failure
Evaluation of a Third and Fourth Dose of StaphVAX® in Adults With End-Stage Renal Disease
This study is a continued evaluation of the immune response to StaphVAX , a Staphylococcus aureus type 5 and 8 capsular polysaccharide conjugate vaccine, in end-stage renal disease patients, by giving a 3rd and 4th dose to a…
- Trial name
- SHIELD-2 (NCT00130260)
- Testing
- Staph aureus types 5 and 8 conjugate vaccine
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Nabi Biopharmaceuticals
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.