Clinical trials: Endocarditis Infective
Infective Endocarditis
CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.
1. Infective Endocarditis (IE) is a rare and serious disease with high morbidity and mortality; 2. Streptoccoci of oral origin are the second more frequent microorganisms responsible for IE; 3.
- Trial name
- 3D STARS (NCT06269679)
- Testing
- CBCT
- Where
- 10 sites in France
- Volunteers
- 170 people
- Sponsor
- Nantes University Hospital
Endocarditis, Bacteremia
Efficacy and Safety of Dalbavancin Compared to Standard of Care Antibiotic Therapy for the Completion of Treatment of Patients With Complicated Bacteremia or Infective Endocarditis
This study will compare dalbavancin to standard of care (SOC) antibiotic therapy for the completion of therapy in patients with complicated bacteremia or infective endocarditis.
- Trial name
- NCT03148756
- Testing
- Dalbavancin, Standard of Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AbbVie
Infective Endocarditis
Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière Hospital
Infective endocarditis (IE) is a severe condition associated with high mortality. Due to the relative low prevalence of IE, prospective data are lacking and current guidelines are mostly based on expert consensus with low level…
- Trial name
- EIPSL (NCT04992923)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bacteremia
A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trial
This is a multicenter, randomized, open-label, noninferiority trial of telavancin versus standard IV therapy control (e.g., vancomycin, daptomycin, anti-staphylococcal penicillin (PCN), or cefazolin) in the treatment of subjects…
- Trial name
- NCT02208063
- Testing
- Telavancin, Vancomycin, Daptomycin
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Cumberland Pharmaceuticals
Infective Endocarditis
Belgian Infective Endocarditis Registry
The objective of this prospective observational registry is to study patients di-agnosed with infective endocarditis (IE) and to gather comprehensive long-term outcome data, including mortality rates and IE-related complications…
- Trial name
- BIER (NCT06745440)
- Volunteers
- 300 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infective Endocarditis
Infective Endocarditis in the Elderly
ELDERL-IE is a multicenter national prospective observational study. The main objective is to describe geriatric characteristics (comorbidities, cognitive status, autonomy, nutritional status, balance and walking) in patients…
- Trial name
- ELDERL-IE (NCT02910856)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Central Hospital, Nancy, France
Infective Endocarditis (IE)
Percutaneous AngioVac Vegetation Extraction (PAVE) to Remove Right Heart Vegetations in Patients With Infective Endocarditis
The investigation aims to demonstrate initial safety and efficacy of the AngioVac System for the removal of vegetation in the right heart in patients with infective endocarditis.
- Trial name
- PAVE (NCT07282002)
- Testing
- AngioVac System
- Volunteers
- 30 people
- Sponsor
- Angiodynamics, Inc.
Infective Endocarditis
Vancomycin, Gentamycin in Infective Endocarditis
Infective endocarditis is a microbial infection of the endocardial surface of the heart.
- Trial name
- NCT03688659
- Testing
- Vancomycin and gentamycin
- Volunteers
- 30 people
- Sponsor
- Assiut University
Infective Endocarditis
18-FDG PET/CT Imaging and Clinical Decisions in Infective Endocarditis
The purpose of this study is to assess the impact of 18-FDG positron emission tomography (PET)/computed tomography (CT) imaging in the management of patients with suspected or proven IE in detecting cardiac valve damages and…
- Trial name
- TEPvENDO (NCT02287792)
- Testing
- 18-FDG PET/CT scan
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endocarditis Infective, Endocarditis, Bacterial
Dalbavancin Therapy for Infective Endocarditis
This study compares two treatment strategies for antibiotic therapy in endocarditis. The aim of the study is to determine which treatment is more effective overall and better tolerated by patients.
- Trial name
- EndoDalba (NCT07699211)
- Testing
- Dalbavancin administration, Standard of Care (Investigator Choice)
- Where
- 9 sites in Germany
- Volunteers
- 184 people
- Sponsor
- Stefan Hagel
Bacteremia, Endocarditis, Bacterial
Predictors of Infective Endocarditis Among Patients Managed for Staphylococcus Aureus Bacteremia, Particularly Staphylococcus Aureus Bacteriuria, and Time to Blood Culture Positivity
Staphylococcus aureus is a frequent cause of primary or secondary bacteremia. It is also responsible for many cases of infective endocarditis, for which the therapeutic management is specific.
- Trial name
- BACT_URIE (NCT05522764)
- Where
- France
- Volunteers
- 247 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Endocarditis, Sepsis
Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE)
Infectious endocarditis (IE) and other severe infections are well-known to induce significant changes in the immune response including immune functionality in a considerable number of affected patients.
- Conditions
- Endocarditis, Sepsis, Septic Shock
- Trial name
- RECREATE (NCT03892174)
- Testing
- Treatment protocol with adsorption
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Endocarditis
Retrospective Review of Management of Infective Endocarditis
This is an analysis of the outcomes of patients having undergone surgical intervention for infective endocarditis.
- Trial name
- NCT00579761
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Endocarditis
Stroke-free Survival Comparison Between Early Surgery and Conventional Therapy in Left Infective Endocarditis
The purpose of the EARLY study is to evaluate the efficacy and effectiveness of early surgery in patients with Infective Endocarditis (IE).
- Trial name
- NCT03411499
- Testing
- Early surgery, Conventional therapy
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Maria Vittoria Hospital
Infective Endocarditis (IE)
Etiology of Endocarditis in Negative Blood Cultures
Infective endocarditis remains a serious disease that requires fast and specialized support in 2012. However, 24% of endocarditis unanswered etiology.
- Trial name
- ENDOC (NCT02816307)
- Testing
- blood samples
- Where
- France
- Volunteers
- 3,033 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infective Endocarditis
Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves.
Therefore, the objective of the study is to characterize the pattern of radiolabeled tracer (18F-FDG) uptake in noninfected transcatheter heart valves in early follow-up after transcatheter aortic valve replacement (TAVR).
- Trial name
- COUNT (NCT03683355)
- Testing
- 18F-FDG PET/CT
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec
Endocarditis
Early Surgery Versus Conventional Treatment in Infective Endocarditis
There have been no prospective clinical studies in infective endocarditis comparing early surgery with the conventional treatment strategy based on current guidelines.
- Trial name
- EASE (NCT00750373)
- Testing
- Valve surgery with removal of vegetations
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Asan Medical Center
Infective Endocarditis
The Predictive Value of Lubricin in Patients With Infective Endocarditis
The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients
- Trial name
- NCT06266741
- Testing
- Lubricin
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Aydin Adnan Menderes University
Infective Endocarditis
Evaluation of a Metabolic Preparation by a Low-carbohydrate Diet as Atkins-diet to Help in Detecting Infective Endocarditis by 18F-FDG PET
Infectious endocarditis (IE) is a pathology where the mortality rate of between 20 and 25%, but a higher morbidity since 50% of the patients are treated by a valvular surgical procedure.
- Trial name
- TEPEIR (NCT03465098)
- Testing
- Strict low carbohydrate diet (< 3gr/day of carbohydrate) before a 18F-FDG PET/CT
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Central Hospital, Nancy, France
Endocarditis, Bacterial, Infective Endocarditis
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia
The overall goals of this study are to compare the safety and efficacy of daptomycin monotherapy 10 mg/kg/day and vancomycin monotherapy dosed to achieve vancomycin trough levels of 15 to 20 μg/mL for the treatment of…
- Trial name
- HDSAB (NCT00695903)
- Testing
- daptomycin, vancomycin
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)