Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Diabetes Mellitus, Type 1, Diabetic Ketoacidosis
Early Administration of Long-acting Insulin Treatment of Diabetic Ketoacidosis in Pediatric Type 1 Diabetes
The management goals of diabetic ketoacidosis (DKA) in the pediatric type 1 diabetes (T1DM) population are fluid and electrolyte repletion, insulin administration, and correction of acidosis in order to stabilize the patient.
- Trial name
- NCT02548494
- Testing
- Glargine, IV insulin, Electrolyte Correction
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Chattanooga-Hamilton County Hospital Authority
Type 1 Diabetes, Type 2 Diabetes
Breaking Down Barriers to Diabetes Self-Care
Performance of self-care recommendations is key to the successful treatment of diabetes. However, many patients have difficulty adhering to diabetes self-care recommendations.
- Trial name
- NCT00142922
- Testing
- Breaking Down Barriers
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus
Open-Label Study of Dimethyl Fumarate in Adults With Type 1 Diabetes
This is a non-randomized, parallel-controlled, single-center, open-label clinical trial designed to evaluate the efficacy of dimethyl fumarate in preserving pancreatic beta-cell function in adults with type 1 diabetes, as well as…
- Trial name
- NCT07548996
- Testing
- Dimethyl Fumarate Enteric-coated Capsules, Insulin
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Nanjing Medical University
Type 1 Diabetes
Effectiveness of Aerobic Exercise to Mitigate Hyperglycemia After Fasted Resistance Exercise
Certain types and timings of exercise are known to cause hyperglycemia (high blood glucose) in people with type 1 diabetes. Hyperglycemia increases the risk of most long-term complications for individuals with this complication.
- Trial name
- NCT05203653
- Testing
- Resistance exercise only, Resistance exercise plus cool down
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Alberta
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
AI-Predicted Disease Trajectories in Diabetes: A Retrospective Study
The study explores the utilization of artificial intelligence (AI) to predict disease progression trajectories in patients with diabetes.
- Trial name
- AI-TRYDIA (NCT06280729)
- Testing
- AI-Analyis
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Diabetes Mellitus, Type I, Stigma
Effects of Education on Stigma and Quality of Life in Individuals With Type 1 Diabetes
This clinical trial aimed to examine the effects of anti-stigma psychoeducation based on the Roy Adaptation Model on stigma and quality of life in individuals with Type 1 Diabetes.The main questions it aims to answer are: 1.
- Conditions
- Diabetes Mellitus, Type I, Stigma, Quality of Life (QOL)
- Trial name
- NCT06850441
- Testing
- Psychoeducation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Izmir Katip Celebi University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
A Canadian Study of the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellitus
The purpose of this study is to collect historical data in real life conditions in a large group of people who have type 1 or type 2 diabetes and were treated with Tresiba® (insulin degludec) for at least 6 months.
- Trial name
- CAN-TREAT (NCT03674866)
- Testing
- Insulin degludec
- Where
- 32 sites in Canada
- Volunteers
- 662 people
- Sponsor
- Novo Nordisk A/S
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Type 1 Diabetes (T1D), Surgery, Day
Efficacy and Safety of the Minimed 780G® Advanced Hybrid Closed Loop System (AHCL) in Patients With Type 1 Diabetes Undergoing Surgery
An analytical observational study based on a cohort of patients who received training at San Ignacio University Hospital. Glycemic control metrics were compared between the perioperative and postoperative periods and the…
- Trial name
- AHCL & surgery (NCT06947031)
- Testing
- AHCL
- Where
- Colombia
- Volunteers
- 15 people
- Sponsor
- Hospital Universitario San Ignacio
Type 1 Diabetes
The Management of Glucose Control and Hypoglycemic Prevention Using Continuous Glucose Monitoring System in Patients With Type 1 Diabetes
This study was designed to evaluate the glucose control and hypoglycemic prevention effect of using continuous glucose monitoring system(CGMS) in patients with type 1 diabetes.
- Trial name
- NCT04684030
- Testing
- Continuous glucose monitoring system(CGMS), Self-monitoring of blood glucose (conventional fingerpricking method)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Diabetes Mellitus, Diabetes Mellitus, Adult-Onset
Classification of Adult-onset Diabetes in Five Subgroups in Pakistani Population
This study aims to classify adult-onset diabetes patients into distinct data-driven clusters, such as severe insulin-deficient, severe insulin-resistant, mild obesity-related, and mild age-related diabetes, based on clinical and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Adult-Onset, Diabetes Mellitus Type 1 and 2
- Trial name
- NCT06706609
- Volunteers
- 394 people
- Sponsor
- Getz Pharma
Type 1 Diabetes Mellitus
Crossover Feasibility Study of Portable AP Device With Zone-MPC and HMS and Adapted I:C and Basal Insulin
The purpose of this trial is to assess the performance of an Artificial Pancreas (AP) device using the Portable Artificial Pancreas System (pAPS) platform for subjects with type 1 diabetes using an insulin pump and rapid acting…
- Trial name
- DP3 (NCT01929798)
- Testing
- portable Artificial Pancreas
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes, Diabetes Mellitus, Type 1
Comparison of Insulin Detemir With NPH Insulin in Type 1 Diabetes
This trial is conducted in Africa, Asia, Europe, Oceania, and South America. The aim of this research study is to compare the efficacy (reduction in HbA1c and in blood glucose levels) of insulin detemir compared to NPH insulin…
- Trial name
- NCT00184665
- Testing
- insulin detemir, insulin NPH, insulin aspart
- Where
- 29 sites in Argentina, Australia and 8 more
- Volunteers
- 501 people
- Sponsor
- Novo Nordisk A/S
Insulin-dependent Diabetes Mellitus, Diabetes Mellitus
Evaluation of a Diabetes Vaccine in Newly Diagnosed Diabetics
Insulin dependent diabetes mellitus (also called type 1 diabetes mellitus or T1DM) is caused by the destruction of insulin-producing cells in the pancreas.
- Trial name
- NCT00057499
- Testing
- IBC-VS01
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Telehealth Family Coaching With Type 1 Diabetes
Telehealth is a delivery format that shows promise, and occupation-based coaching (OBC) is one intervention that can be delivered via telehealth.
- Trial name
- NCT04753099
- Testing
- occupation-based coaching
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Creighton University
Diabetes, Diabetes Mellitus, Type 1
Impact of Two Medtronic Infusion Sets on Lipohypertrophy in Type 1 Diabetes (T1DM) Patients Thought to Have LH
This is an observational study using ultrasound (US) and palpation to assess the impact of infusion sets on lipohypertrophy (LH) in an infusion set crossover study.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Lipohypertrophy
- Trial name
- NCT06074965
- Testing
- Medtronic Extended Infusion Set
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Azienda Ospedaliera San Camillo Forlanini
Diabetes Mellitus, Type 1
SWITCH - Sensing With Insulin Pump Therapy to Control HbA1c
The primary objective of this study is to evaluate whether the patients with Type 1 diabetes mellitus in sub-optimal glycemic control can achieve better glycemic control by using the Medtronic MiniMed Paradigm® REAL-Time Pump…
- Trial name
- SWITCH (NCT00598663)
- Testing
- insulin pump with continuous glucose sensing (Paradigm Real-Time Insulin Pump System), insulin pump and blinded continuous glucose sensing (Paradigm Real-Time insulin pump)
- Where
- 8 sites in Austria, Denmark and 5 more
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes Mellitus
Afrezza Safety and Pharmacokinetics Study in Pediatric Patients
Primary Objective: -To assess the safety and tolerability of Afrezza in children ages 4 to 17 years with type 1 diabetes mellitus (T1DM).
- Trial name
- NCT02527265
- Testing
- Afrezza
- Where
- 13 sites in United States
- Volunteers
- 30 people
- Sponsor
- Mannkind Corporation
Pancreas Transplant, Type 1 Diabetes Mellitus
Pancreas Transplant Alone in Uremia and Non-uremia Patients
Theoretically, pancreas transplant alone in uremia (PTAu) or pancreas before kidney transplant (PBK) may be considered for patients awaiting both pancreas and kidney grafts, alongside options like simultaneous pancreas-kidney…
- Conditions
- Pancreas Transplant, Type 1 Diabetes Mellitus, Uremia
- Trial name
- PTAu (NCT07872800)
- Testing
- pancreas transplant
- Where
- Taiwan
- Volunteers
- 184 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Type 1 Diabetes
Safety of Artificial Pancreas Therapy in Preschoolers, Age 2-6
A single-arm, multi-center, clinical study to assess the safety profile of the Tandem t:slim X2 with Control-IQ system in children with T1D aged 2-6 years old under free living condition
- Trial name
- NCT04084171
- Testing
- Tandem t:slim X2 with Control-IQ Technology + Dexcom G6
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
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