Clinical trials: Endocrine, Nutritional, Metabolic and Immunity Disorders
Diabetes, Type I
Childhood Diabetes
Purpose of the study: To compare three different regimes for children newly diagnosed with type 1 diabetes: (1) traditional hospital based care, (2) intensive psychological support to the family, and (3) home based family…
- Trial name
- NCT00804232
- Testing
- childhood diabetes
- Where
- 2 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Diabetes Mellitus, Type 1, Acute Stroke
Glycaemic Variability in Acute Stroke
Increased glycaemic variability is associated with worse outcome in patients with diabetes after acute stroke.
- Trial name
- G-VAS (NCT04521634)
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Imperial College London
Coronary Disease, Myocardial Infarction
Chronical Illness-related Limitations of the Ability to Cope With Rising Temperatures: an Observational Study
The CLIMATE Observational Study examines to what extent chronically ill patients experience adverse health effects because of heat and whether the patients' specific efforts, somatosensory amplification, self-efficacy, health…
- Conditions
- Coronary Disease, Myocardial Infarction, Heart Failure, Arrhythmias, Cardiac
- Trial name
- CLIMATE (NCT05961163)
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Type 1 Diabetes
A Learning Algorithm for MDI Individuals With Type 1 Diabetes to Adjust Recommendations for High Fat Meals and Exercise Management
McGill artificial pancreas lab has developed a learning algorithm using a reinforcement learning approach to adjust basal and bolus recommendations for high-fat meals and exercise management for individuals with type 1 diabetes…
- Trial name
- NCT05041621
- Testing
- Sensor augmented MDI therapy plus mobile application
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McGill University
Type 1 Diabetes
Supporting Meal Management in Type 1 Diabetes
Carbohydrate count marks the cornerstone of Type 1 Diabetes management. Eventhough it is a crucial task, it is burdensome and prone to error.
- Trial name
- SUMMIT1 (NCT05671679)
- Testing
- SNAQ app, Traditional carbohydrate counting
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- Lia Bally
Diabetes Mellitus Type 1, Remission of Type 1 Diabetes
The Influence of Partial Remission Phase of Type 1 Diabetes on Patient Outcome
Natural course of diabetes mellitus involves gradual reduction of β cell mass within islets of Langerhans in the pancreas. Symptoms of diabetes present when the mass of insulin-producing cells reaches a point where insulin…
- Conditions
- Diabetes Mellitus Type 1, Remission of Type 1 Diabetes, Chronic Complications of Diabetes
- Trial name
- POZREM (NCT02220257)
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Poznan University of Medical Sciences
Type 1 Diabetes
Glu-COACH: a Peer-mentoring Intervention to Reduce Disparities in Continuous Glucose Monitor (CGM) Use
This is a study to develop and evaluate a peer mentoring intervention for Black and Latinx adolescents with type 1 diabetes to increase the initiation and maintenance of a continuous glucose monitoring (CGM) device.
- Trial name
- Glu-COACH (NCT06171412)
- Testing
- Glu-COACH
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 1
Islet Transplantation for Patients With Type 1 Diabetes
This protocol will test whether Type 1 diabetes (T1DM) can be reversed in patients with stable renal allografts by islet transplantation.
- Trial name
- NCT00073281
- Testing
- Islet transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1
Insulin Glargine in Type I Diabetes Mellitus> Main Study "AT.LANTUS": A Trial Comparing Lantus Algorithms to Achieve Normal Blood Glucose Targets in Subjects With Uncontrolled Blood Sugar. Sub-study: "HALT"(Hypoglycaemia Avoidance With Lantus Trial)
Primary objective: AT.LANTUS main study* To determine the optimal treatment algorithm for insulin glargine based on the incidence of severe hypoglycaemia.(*Target Number of patients for the main study:2346) HALT Sub-study** To…
- Trial name
- AT-LANTUS (NCT00390728)
- Testing
- Insulin Glargine
- Volunteers
- 2,346 people
- Sponsor
- Sanofi
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Type 1 Diabetes
Advanced Bolus Calculator for Type 1 Diabetes (ABC4D)
This study aims to assess the safety and efficacy of a novel advanced bolus calculator in subjects with Type 1 diabetes. Insulin bolus calculators have been developed to aid insulin dose adjustment and existing standard insulin…
- Trial name
- ABC4D (NCT02053051)
- Testing
- ABC4D, Standard bolus calculator
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Diabetes Mellitus, Type 1
CGM Treatment in Patients With Type 1 Diabetes Treated With Insulin Injections
Breif summary A keystone in preventing diabetic complications in patients with type 1 diabetes is good glycaemic control. Frequent self-measurements of blood glucose (SMBG) levels has been an essential part of insulin dosing…
- Trial name
- NCT02092051
- Testing
- Continuous glucose monitoring with DexCom G4 platina
- Where
- 15 sites in Sweden
- Volunteers
- 161 people
- Sponsor
- Vastra Gotaland Region
Diabetes Mellitus, Diabetes Mellitus, Type 1
An International Non-interventional Cohort Study to Evaluate the Safety of Treatment With Insulin Detemir in Pregnant Women With Diabetes Mellitus. Diabetes Pregnancy Registry
This study is conducted in Europe and Asia. The purpose of the study (Diabetes Pregnancy Registry) is to evaluate the safety of treatment with insulin detemir in pregnant women with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01892319
- Testing
- insulin detemir, other injectable antidiabetic treatment regimens
- Where
- 93 sites in Croatia, Finland and 14 more
- Volunteers
- 2,446 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Transdisciplinary Care for Young Adults With Type 1 Diabetes
The incidence of type 1 diabetes (T1D) is increasing globally with the most substantial increases occurring in the youngest age groups.
- Trial name
- TCT (NCT06172166)
- Testing
- Transdisciplinary Care for Transition
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Nemours Children's Clinic
Type 1 Diabetes
Alpha-lipoic Acid in Diabetic Nephropathy
Endothelial dysfunction in diabetes is a central event in the pathogenesis of different microangioapthic changes. Nephropathy in patients with type 1 diabetes is a severe microvascular complication.
- Trial name
- NCT06253429
- Testing
- Thioctic Acid 333 MG Oral Capsule, Captopril 25Mg Tab
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Type 1 Diabetes
A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
The objective of this trial is first to evaluate safety and then the effect on preservation of residual beta cell function also clinical efficacy by treatment with Verapamil in children with recent onset Type 1 diabetes.
- Trial name
- VERADIAB-1 (NCT07199946)
- Testing
- Verapamil (Part A)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Johnny Ludvigsson
Type 1 Diabetes
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus
Elevations of plasma cortisol, a stress hormone, during prior episodes of low blood sugar (hypoglycemia) appear to be responsible for the deficient responses during subsequent hypoglycemia.
- Trial name
- NCT00607646
- Testing
- Dehydroepiandrosterone
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Asthma
Levels of Serum Resistin in Asthmatics as a Potential Marker of Systemic Inflammation and Disease State.
The purpose of this study is to determine whether serum resistin levels in asthmatics are elevated. We will recruit subjects from the allergy/immunology clinic with a prior diagnosis of moderate to severe persistent asthma in…
- Trial name
- NCT00339703
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Diabetes Mellitus, Type 1
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Type 1 diabetes (T1D) is an autoimmune disease. This means that the immune system (the part of the body which helps fight infections) mistakenly attacks and destroys the cells that produce insulin (islet cells found in the…
- Trial name
- TN07 (NCT00419562)
- Testing
- Oral Insulin
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 560 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes Mellitus, Type 1, Insulin Hypoglycemia
Effects of Frequency and Duration of Exercise in People With Type 1 Diabetes A Randomized Crossover Study
According to the Standards of Medical Care in Diabetes by the American Diabetes Association, people with diabetes should aim for 30 minutes of moderate-to-vigorous intensity aerobic exercise at least 5 days a week or a total of…
- Trial name
- NCT04089462
- Testing
- "Five sessions per period" - "Two sessions per period", "Two sessions per period" - "Five sessions per period"
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Steno Diabetes Center Copenhagen
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