Clinical trials: Endocrine Cancer
Ovarian Cancer
Fluzoparib+Bevacizumab/Dietary Intervention vs Fluzoparib Monotherapy as First-line Maintenance in HRD+/- Advanced Ovarian Cancer
Fluzoparib has been approved for the first-line maintenance treatment of advanced ovarian cancer in the full population . Previous studies have demonstrated that anti-angiogenic agents enhance tumor cell sensitivity to PARP…
- Trial name
- NCT06954584
- Testing
- Bevacizumab, Fluzoparib Monotherapy, Dietary Intervention
- Where
- 2 sites in China
- Volunteers
- 424 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Polycystic Ovary Syndrome (PCOS), Menstrual Irregularity
Nutritional and Metabolic Correlates of Ovarian Morphology in Women With Polycystic Ovary Syndrome
The investigators would like to determine how aspects of metabolism and age influence ovarian function. The purpose of the study is to understand how nutrition and metabolism relate to follicle development in women with regular…
- Trial name
- NCT01927471
- Where
- 3 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Cornell University
Insulin Resistance, Diabetes
Diet and Metabolic Inflammation
Obesity is a risk factor for several common cancers, including those of the breast, colon, liver, and pancreas. Proposed molecular links between obesity and these types of cancer include systemic inflammation, hyperinsulinemia…
- Conditions
- Insulin Resistance, Diabetes, Cancer, Obesity
- Trial name
- NCT02539355
- Testing
- Diet A, Diet B
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Smoking Cessation
Yoga for Men Attempting Smoking Cessation
The purpose of this pilot study is to examine the feasibility and preliminary efficacy of a quit-smoking program that combines behavioral therapy with either yoga, or a health \& wellness program that serves as a contact control.
- Trial name
- NCT02055326
- Testing
- Cognitive Behavioral Therapy for Smoking Cessation, Yoga, Health & Wellness
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Cardiovascular Disorder, Coronary Artery Disease
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
This clinical trial develops and tests a culturally-appropriate educational program (Indigenous SIPin) for reducing sugar-sweetened beverage consumption in men affiliated with Native American athletics communities.
- Conditions
- Cardiovascular Disorder, Coronary Artery Disease, Diabetes Mellitus, Obesity-Related Malignant Neoplasm
- Trial name
- NCT06029517
- Testing
- Education Intervention, Observation of Indigenous SIPin Interventon, Discussion
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Men
Nutritional Evaluation of Canola Protein in Comparison With Soy Protein
The objective of the study is to evaluate the nutritional and physiological properties of two canola proteins focusing on the bioavailability in humans.
- Trial name
- NCT01481584
- Testing
- Protein drink - protein isolate, Protein drink - protein hydrolyzate
- Where
- Germany
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Jena
Thyroid Tumor, Breast Tumor
Detection of Benign and Malignant Thyroid and Breast Tumors by Fourier Transform Infrared Spectrometry
The purpose of this stage of study is to establish discriminant among healthy tissue, benign and malignant thyroid and breast tumors by fourier transform infrared spectrometry variables.
- Trial name
- NCT01668238
- Where
- China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- XU Zhi
Precursors to PCOS
Research Study for Children With a Mother or Sister With Polycystic Ovary Syndrome
In this study, we want to find out more about polycystic ovary syndrome(PCOS). This is a common problem in about 7% of teenage girls. Problems may include irregular periods, extra hair on the face, chest and back areas.
- Trial name
- PCOS (NCT00559390)
- Where
- United States
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Polycystic Ovary Syndrome
Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17
The purpose of this study is to see if substances contained in ginger or aloe plants, called exosomes, will treat and improve the condition polycystic ovary syndrome
- Trial name
- NCT03493984
- Testing
- Ginger exosomes, Aloe exosomes
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Polycystic Ovary Syndrome
Cardiovascular Risk Markers in Polycystic Ovary Syndrome (PCOS)
Women with polycystic ovary syndrome (PCOS) are more often overweight or obese and are more insulin resistant than women without the condition and may be at greater risk of developing cardiovascular disease.
- Trial name
- CS (NCT01195168)
- Where
- 2 sites in Ireland
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- The Adelaide and Meath Hospital
Thyroid Cancer, Thyroidectomy With Central Lymph Node Dissection
Does Parathyroid Autofluorescence Reduces Unintensional Parathyroidectomy During Total Thyroidectomy With Central Lymph Node Compartment Dissection
The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.
- Trial name
- FLUOBCC (NCT04339478)
- Where
- 2 sites in Greece, Jordan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Proteomics, Pancreatic Cancer
Prognostic Biomarkers of Pancreatic Cancer Based on Proteomic Techniques
Sequence I (Retrospective study: proteomic analysis of pathological specimens and information collection of previous patients with pancreatic cancer) Sequence 2 (Non-interventional prospective study, sample and information…
- Conditions
- Proteomics, Pancreatic Cancer, Prognostic Biomarkers
- Trial name
- NCT05289895
- Testing
- No intervention
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn How Much Rosuvastatin Gets Into the Blood When Taken With or Without Elinzanetant and to Learn About the Safety of Elinzanetant in Healthy Participants
Researchers are looking for a better way to treat people who have symptoms caused by hormonal changes, like those that happen in women during menopause. These symptoms can include vasomotor symptoms.
- Trial name
- NCT04889287
- Testing
- Elinzanetant (BAY3427080), Rosuvastatin
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Ovarian Cancer
Early Detection of Ovarian Cancer Using Plasma Cell-free DNA Fragmentomics (Retrospective Study)
The purpose of this study is to enable non-invasive early detection of ovarian cancer in high-risk populations through the establishment of a multimodal machine learning model using plasma cell-free DNA fragmentomics.
- Trial name
- NCT05693974
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Ovarian Cancer
Salpingectomy at Cesarean Delivery for Ovarian Cancer Reduction (SCORE)
To compare the feasibility and surgical outcomes between complete salpingectomy and standard postpartum tubal ligation (partial salpingectomy) at the time of cesarean delivery in women with undesired future fertility.
- Trial name
- SCORE (NCT02374827)
- Testing
- Standard postpartum tubal ligation, Complete Salpingectomy
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Oral Microbiome, Pancreatic Cancer
Pancreatic Cancer and Oral Microbiome
Pancreatic cancer (PC) is a solid malignancy with a dismal prognosis. It has a 5-year survival rate of approximately 8%. This is due to the usually late diagnosis, to chemoresistance, and to intrinsic biological aggressiveness.
- Conditions
- Oral Microbiome, Pancreatic Cancer, IPMN, Parodontopathy
- Trial name
- NCT04993846
- Testing
- Dental plaque sampling, qPCR
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Cancer Survivor, Diabetes Mellitus
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant
This pilot clinical trial studies computed tomography (CT) scans and biomarker analysis in diagnosing coronary artery disease (CAD) in patients who have undergone a stem cell transplant but have no symptoms of CAD.
- Conditions
- Cancer Survivor, Diabetes Mellitus, Hypertension
- Trial name
- NCT02077218
- Testing
- computed tomography, cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
HIV Testing, Linkage to Care
Multidisciplinary Services to Enhance HIV Testing and Linkage to Care Among MSM
Objectives 1. To determine the impact of MSM-targeted multidisciplinary services on uptake of HIV voluntary counseling and testing (VCT) 2.
- Trial name
- NCT01637324
- Where
- Thailand
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Chronic Disease, Cancer
A Nutritarian Study to Evaluate the Effectiveness of Lifestyle Changes in Chronic Disease Prevention, Especially Cancer
The Nutritarian Women's Health Study (NWHS) is a long-term hybrid effectiveness-implementation study on the effect of the Nutritarian Diet on the occurrence, recurrence, and progression of chronic diseases (including all forms of…
- Conditions
- Chronic Disease, Cancer, Cardiovascular Diseases, Diabetes Mellitus
- Trial name
- NWHS (NCT03430141)
- Testing
- Nutritarian Diet-style
- Where
- United States
- Volunteers
- 2,898 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Thyroid Cancer
Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study
Background: The Ukrainian Research Center for Radiation Medicine and the U.S. National Institutes of Health have been studying cancer risks and outcomes in individuals who participated in the decontamination clean-up process…
- Trial name
- NCT01265381
- Where
- Ukraine
- Volunteers
- 673 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
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