Clinical trials: Endocrine Disorder
Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients
Neuroendocrine neoplasms (NENs) are a heterogeneous group of lesions derived from cells with the ability to produce hormones that may arise from multiple different organs.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Neoplasm of Gastrointestinal Tract, Neuroendocrine Neoplasm of Lung, Thymic Neuroendocrine Neoplasm
- Trial name
- NCT06523582
- Where
- 3 sites in Mexico
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Renal Impairment, Type 2 Diabetes Mellitus
Effect of Renal Impairment on the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Ertugliflozin in Participants With Type 2 Diabetes Mellitus (MK-8835-009)
This is a study to evaluate the effect of renal impairment on the pharmacokinetics, pharmacodynamics, safety and tolerability of ertugliflozin in participants with type 2 diabetes mellitus (T2DM) and in healthy participants with…
- Trial name
- NCT01948986
- Testing
- Ertugliflozin
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Complications Associated With Artificial Fertilization, Disorder of Endocrine Ovary
Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention
The purpose of this study is to assess whether, in GnRH agonist in vitro fertilization (IVF) cycles, where there is a risk of ovarian hyperstimulation syndrome (OHSS), the addition of cabergoline to the hydroxyethyl starch…
- Trial name
- NCT01530490
- Testing
- Cabergoline and Hydroxyethyl Starch, Hydroxyethyl Starch
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospital de Cruces
Diabetes, Healthy
Comparison of Human Insulin Produced by the Current Process and the NN729 Process in Healthy Volunteers
This trial is conducted in Europe. The aim of this trial is to show that the product of the new production process has a similar pharmacological profile to the traditional process used for the current commercial product Actrapid®.
- Trial name
- NCT01448070
- Testing
- human insulin
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetic Ketoacidosis
Use of Blood Ketone Meters to Improve Ambulance Hyperglycaemia Care
In this KARMA2 feasibility study the investigators are testing whether ambulance staff can reliably and safely identify patients at high risk of diabetic ketoacidosis using blood ketone meters and start fluid (saline) therapy…
- Trial name
- KARMA2 (NCT04940897)
- Testing
- Use of CareSens ketone meter
- Where
- United Kingdom
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- East of England Ambulance Service NHS Trust
Type 1 Diabetes, Type 2 Diabetes
The Effect of Different Food Products on Post Prandial Blood Glucose in Pregnant Woman With Diabetes
During pregnancy nutrition demands change and the pregnant woman needs to adjust her food intake and take into consideration the corrected daily recommendations for micro and macro nutrients.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
- Trial name
- NCT02154997
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uri Elchalal
Diabetes, Gestational
Insulin Sensitivity and Secretion During Pregnancy and Post Partum in Women With Gestational Diabetes.
Aim of the study: To define insulin requirement during pregnancy and to identify the rapid changes in insulin sensitivity around parturition and the first 6 months post partum.
- Trial name
- NCT02770079
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Neoplastic Cells, Circulating
The Detection of CTCs in Patients With Pancreatic Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment.
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. Enumeration and molecular characterization of CTCs in pancreatic cancer could play an important role in…
- Trial name
- NCT02406846
- Testing
- Flow cytometry (FCM), RT-PCR
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Diabetes Mellitus
Using Networks, Informatics, Technology, and Education in Care for People With Diabetes
The costs of diabetes care (in health care dollars \& human suffering) in the United States are second only to mental illness. Randomized control trials \& observational studies have shown that glycemic control is predictive of…
- Trial name
- NCT00421850
- Testing
- UNITED Planned Care
- Where
- United States
- Volunteers
- 3,491 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Periodontitis, Peri-Implantitis
Periodontitis and Inflammation
Today, to understand pathogenic mechanisms involved in periodontitis and peri-implantitis remains a challenge to identify biomarkers or therapeutic targets to improve prevention and screening, as well as the effectiveness of…
- Trial name
- CB-PARO (NCT04831060)
- Testing
- Periodontal or peri-implantitis treatment, Control treatment
- Where
- 2 sites in France
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Adrenal Insufficiency
Cortisol Response to Low Dose Cosyntropin Stimulation Test in the Late Afternoon
Previous study showed that afternoon cosyntropin testing was associated with a sevenfold increased likelihood of failing the 1μg test.
- Trial name
- NCT03074123
- Testing
- low-dose cosyntropin stimulation test
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Obesity, Weight Loss
Lorcaserin in Obesity: Identification of CNS Targets Using fMRI
The purpose of this protocol is to investigate, using functional magnetic resonance imaging (fMRI), the effect of treatment with lorcaserin on centers of the brain that control appetite and food intake, as well as lorcaserin's…
- Trial name
- NCT02400359
- Testing
- Lorcaserin HCl
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Motivational Interviewing, Stress
Motivational Interviewing Applied to Individuals With Diabetes
This study will be conducted using a randomized controlled trial design to evaluate the effect of online individual motivational interviewing on well-being, stress and difficulties in individuals with diabetes.
- Conditions
- Motivational Interviewing, Stress, Well-Being, Psychological, Diabetes Mellitus
- Trial name
- NCT06345196
- Testing
- motivational interview
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bozok University
Type 2 Diabetes Mellitus
Safety Study of ISIS 325568 in Healthy Volunteers
The primary purpose of this trial is to assess the safety of ISIS 325568 when given at increasing single doses and to assess the safety of the same doses when given multiple times.
- Trial name
- NCT00519727
- Testing
- ISIS 325568
- Where
- Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Diabetes, Healthy
Pharmacokinetics of Biphasic Insulin Aspart 50 and 70 in Japanese Healthy Volunteers
This trial is conducted in Japan. The aim of this trial is to investigate the pharmacokinetics of biphasic insulin aspart 50 (NN-X14Mix50) and biphasic insulin aspart 70 (NN-X14Mix70) in Japanese healthy volunteers.
- Trial name
- NCT01620333
- Testing
- biphasic insulin aspart 50, biphasic insulin aspart 70
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetic Retinopathy
The Diabetic Retinopathy Screening, Prevention and Control Program
The greatest harm of diabetes is various acute and chronic complications, especially diabetic retinopathy(DR), leading to extremely high rates of disability and blindness.
- Trial name
- NCT04240652
- Where
- 2 sites in China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pancreatic Cancer, Jaundice
The LINFU® U.S. Registry in Patients With Clinical Signs and/or Symptoms of Disease
Evaluate LINFU® in patients who exhibit signs or symptoms (i.e. jaundice, abdominal pain, weight loss, nausea and vomiting etc.) suggestive of pancreatic cancer (PDAC) or have evidence of imaging studies suggestive of PDAC.
- Conditions
- Pancreatic Cancer, Jaundice, Abdominal Neoplasm
- Trial name
- NCT06276738
- Testing
- LINFU® (Low Intensity Non-Focused Ultrasound excitation of the pancreas)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Adenocyte, LLC
Polycystic Ovary Syndrome, IVF
Follicular Fluid Raman Shifts and IVF Outcomes
This study intends to collect about 150 cases of follicular fluid samples from PCOS and non-PCOS infertility patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles (in clinical…
- Trial name
- NCT04838535
- Testing
- Raman spectrum
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Mitochondrial Disorders, Mitochondrial Genetic Disorders
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
- Conditions
- Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes
- Trial name
- NAMDC (NCT01694940)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pancreatic Neoplasm
Core Biopsy Endo Sonography Study Evaluation of the Significance of the Pro-core® Needle
The study is designed to evaluate the diagnostic accuracy of a new designed endoscopic ultrasonography (EUS) Core biopsy aspiration needle in comparison to a conventional EUS aspiration needle in GI-tumors.
- Trial name
- COS (NCT02181140)
- Testing
- EUS guided FNA and fine needle punction
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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