Clinical trials: Endocrine Disorder
Adrenal Hyperplasia, Congenital
Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
21-hydroxylase deficiency (21-OHD) is an inherited disorder that results from a mutation on the CYP21A2 gene. It affects the adrenal glands and is the most common cause of congenital adrenal hyperplasia (CAH).
- Trial name
- NCT00694525
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Office of Rare Diseases (ORD)
Type 2 Diabetes Mellitus
Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus (T2DM)
It is anticipated that 7 days of oral administration of 10 mg dapagliflozin will reduce the renal glucose reabsorption similarly in healthy subjects and in subjects with T2DM.
- Trial name
- NCT01165268
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes Mellitus
A Drug Interaction Study of SLM0807 and HKB0701 in Healthy Subjects
The aim of this study is to assess whether HKB0701 alters pharmacokinetics of SLM0807.
- Trial name
- NCT01039896
- Testing
- Period I : SLM0807, Period II : HKB0701 and SLM0807, Period I : HKB0710 and SLM0807, Period II : SLM0807
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Chronic Kidney Diseases, Hypertension
Risk Factors and Multiomics Study of Chronic Kidney Disease Caused by Metabolic Diseases
With the development of China's economy, people's living standard have improved, and the dietary structure have changed. Metabolic diseases, such as hypertension, diabetes, hyperuricemia and obesity have gradually become an…
- Conditions
- Chronic Kidney Diseases, Hypertension, Diabetes Mellitus, Hyperuricemia
- Trial name
- NCT05476627
- Testing
- Biomarkers
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Cancer
Analyzing Childhood Recall Antigens in Patients With Pancreatic Cancer
The investigator is developing an immune therapy against pancreatic cancer. Immune cells, known as "T cells with tumor killing capacity", are involved in this immune therapy.
- Trial name
- NCT03848182
- Testing
- Gemcitabine, TT vaccine booster
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Ovary Torsion, Adnexal Torsion
Biomarker Panel in Ovarian Torsion
The overall goal of the project is to find a panel of novel biomarkers for early detection of ovarian torsion.
- Trial name
- NCT05060120
- Testing
- biomakers for ovarian torsion, peritoneal fluid proteins analysis
- Where
- 2 sites in Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assuta Ashdod Hospital
Diabetes Mellitus
Accuracy Study for Enhanced Meter Feature
This enhanced meter feature raises awareness among patients by providing additional information regarding their glycemic control between Healthcare Professional visits.
- Trial name
- NCT01885546
- Testing
- AgaMatrix Blood Glucose Monitor
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- AgaMatrix, Inc.
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Diabetic Complication, Covid19 Virus Infection
Suspicion of Hypoglycemic Effect of mRNA Based Covid-19 Vaccines (Polyethylene Glycol) Will Happen , Observational Study on Diabetic Patients at Saudia Arabia
vaccines for covid-19 are gold strategy and great achievement at this century for protection against complications of covid-19 , development of many vaccines with different technology represent a big challenge for this disease so…
- Conditions
- Diabetic Complication, Covid19 Virus Infection, Hypoglycemia, Polyethylene Glycol Adverse Reaction
- Trial name
- NCT05087225
- Testing
- polyethelyene glycol
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Type 2 Diabetes Mellitus, Impaired Glucose Tolerance
Effects of Colesevelam HCl On Bile Acid Kinetics
This project will compare the amount of bile acids and their kinetics in overweight and obese people with normal glucose metabolism, impaired glucose tolerance and frank type 2 diabetes.
- Trial name
- NCT00476710
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- KineMed
PreDiabetes, Impaired Glucose Tolerance
Glucose Homeostasis and Apple Polyphenols
The primary objective is to investigate the effect of apple polyphenol supplementation for 12 weeks on glucose homeostasis in prediabetic individuals.
- Conditions
- PreDiabetes, Impaired Glucose Tolerance, Glucose Metabolism Disorders
- Trial name
- NCT05951270
- Testing
- Apple Polyphenols, Control
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Testicular Cancer
Testicular Self-Examination Awareness in Young Men
This study aims to determine the effect of education based on the health belief model on testicular self-examination awareness and health beliefs in young men.
- Trial name
- NCT06318182
- Testing
- Education
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hitit University
Type 1 Diabetes, Osteoporosis
Bone Health in Youth With Type 1 Diabetes
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls.
- Trial name
- NCT02140424
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy
Imaging Histone Deacetylase in the Heart
The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.
- Conditions
- Heart Failure With Normal Ejection Fraction, Left Ventricular Hypertrophy, Aortic Valve Stenosis, Diabetes
- Trial name
- NCT03549559
- Testing
- 11C-Martinostat, PET-MRI
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Macular Degeneration, Glaucoma
Tracking Optical Coherence Tomography
The purpose of this research study is to evaluate an investigational system that may allow doctors to show images of the different parts inside the eye that show greater detail than current equipment can produce.
- Conditions
- Macular Degeneration, Glaucoma, Diabetic Retinopathy, Choroidal Disease
- Trial name
- NCT00343603
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes Type 1
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
Arterial vascular disease is the major cause of morbidity and mortality for Type 1 diabetic patients (DM1). Metabolic insulin resistance (metIR), even in the absence of hyperglycemia, conveys a 1.5 to 3-fold increased CVD risk in…
- Trial name
- EJB046 (NCT02490124)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Growth Hormone Deficiency
Cardiovascular Risk in Growth Hormone Deficient Young Adult Males After Completing Growth Hormone Therapy
The purpose of this study is to compare the cardiovascular risks of growth hormone deficient young adult males who have completed growth hormone therapy to healthy young adult males.
- Trial name
- NCT00711061
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Insulin Resistance, Transcranial Direct Current Stimulation
Improving Insulin Sensitivity by Non-invasive Brain Stimulation
Efforts in curing and preventing obesity and type 2 diabetes (T2D) have been elusive thus far. One reason for that is the lack of understanding of the role of the brain in the development and treatment of the disease.
- Conditions
- Insulin Resistance, Transcranial Direct Current Stimulation, Obesity, Diabetes
- Trial name
- NCT04420650
- Testing
- transcranial direct current stimulation
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Diabetes Mellitus
Effect of Rifampicin on the Pharmacokinetics and Pharmacodynamics of Sotagliflozin
Primary Objective: To evaluate the effects of rifampicin on the pharmacokinetics (PK) of sotagliflozin and its metabolite in healthy male and female subjects.
- Trial name
- NCT03063580
- Testing
- Sotagliflozin (SAR439954), Rifampicin
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sanofi
Covid19, Diabetes Mellitus
The Effect of Diabetes Mellitus on Mortality of Patients With COVID-19
The study includes patients over 18 years old who were hospitalized in our covid intensive care unit between March 16 and May 16, 2020. Retrospective records were examined by examining the electronic data files of the patients.
- Trial name
- NCT04663659
- Testing
- no intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
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