Clinical trials: Endocrine Disorder
Type 2 Diabetes and Exercise
Influence of Moderate Exercise on Blood Glucose in Type 2 Diabetics and Healthy Controls
Project description Research project title: Influence of moderate exercise on blood glucose in type 2 diabetics and healthy controls.
- Trial name
- DIEGO (NCT01765894)
- Testing
- 45 minutes of moderate exercise at the fasted state. Before test day 2: 3 days of carbohydrate loading.
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Diabetes
Ultrasound Evaluation of Gastric Emptying in Diabetic Patients
This is a prospective cohort study. The main objective is to compare the frequency of a "full stomach" in the diabetic population compared to healthy controls 2 h after clear liquid and 6h after a light meal, and evaluate the…
- Trial name
- NCT03187145
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- West China Hospital
Type 1 Diabetes Mellitus
A Phase 2 Two-Part Study of Oral PS1 in Healthy Volunteers and Adults With Newly Diagnosed Type 1 Diabetes
This study consists of 2 sub-studies, including Part A and Part B. Part A is intended to further characterize the pharmacokinetic (PK) profile of PS1 based on existing single ascending dose (SAD) and multiple ascending dose (MAD)…
- Trial name
- NCT07889505
- Testing
- PS1
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pharmasaga Co. Ltd.
Type 2 Diabetes
Single Ascending Dose Study With Healthy Male Volunteers and Type II Diabetic Patients
The purpose of this study is to assess safety and tolerability of AZD6714 after single ascending oral doses in healthy male subjects and type 2 diabetic patients.
- Trial name
- NCT00886366
- Testing
- AZD6714
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCL 25mg/5mg/1000mg Extended-Release Tablets Versus Trijardy® XR Extended Release Film Coated Tablets
Randomized, Single Oral Dose, Two-period, Two Sequence, Open-label, Crossover, Bioequivalence Study to Compare Empagliflozin-Linagliptin-Metformin XR Tablet 25mg/ 5mg/1000mg (25mg Empagliflozin /5mg Linagliptin /1000mgMetformin…
- Trial name
- NCT07213895
- Testing
- Empagliflozin/Linagliptin/Metformin HCL, Trijardy® XR Extended release film coated tablets
- Where
- Jordan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
PreDiabetes
A Trial to Assess Diets Containing Beef vs. Poultry on Pancreatic Beta-Cell Function
The objective of this study is to assess and compare the effects of usual diets containing lean beef vs. lean poultry on pancreatic beta-cell responses in men and women with prediabetes.
- Trial name
- NCT05456477
- Testing
- Beef, Poultry
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Type 2 Diabetes
Cut Down on Carbohydrate Usage in the Diet of Type 2 Diabetes - Mechanisms of Effective Therapy of Diabetes by Selective Choice of Macronutrients - The Phenotype Study
Scientific evidence for the dietary treatment of type 2 diabetes is insufficient. The investigators hypothesize that a lower carbohydrate content in the diabetic diet than the recommended 55 E% will decrease the postprandial…
- Trial name
- CutDM (NCT02472951)
- Testing
- Low carbohydrate meals, Standard carbohydrate meals
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Oxidative Stress, Endocrine Disrupting Chemicals
Oxidative Stress and Bisphenol A (BPA) Impact With Polycystic Ovary Syndrome (PCOS)
Both oxidative stress and Bisphenol A (BPA) had been associated with polycystic ovary syndrome (PCOS). BPA, one of endocrine-disrupting chemicals (EDCs), is an environmental estrogen used in the synthesis of plastics, is a…
- Conditions
- Oxidative Stress, Endocrine Disrupting Chemicals, Polycystic Ovary Syndrome
- Trial name
- NCT01600872
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ming-I Hsu
Type 2 Diabetes
Diabetes Nutrition Education for American Indian and Alaska Native Communities
This study involves pilot testing a newly developed diabetes nutrition education program for American Indian and Alaska Native adults with T2D.
- Trial name
- NCT04254653
- Testing
- American Indian and Alaska Native What Can I Eat?
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 2 Diabetes, Insulin Resistance
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity
- Trial name
- NCT00422253
- Testing
- dietary intervention
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Peri-Implantitis
ICG-PDT, Periimplantitis, Diabetes Mellitus
In this study, the effect of photodynamic therapy (indocyanine green mediated) on the clinical, biological and inflammatory aspects was assessed in diabetic patients having peri-implantitis
- Trial name
- NCT04833569
- Testing
- ICG-PDT, peri-implant mechanical debridement
- Where
- Saudi Arabia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King Saud University
Diabetes Mellitus (DM), Type 2 Diabetes Mellitus (T2DM)
Improving the Activation Level of Diabetic Individuals
This study was planned to determine the activation levels of diabetic individuals and to improve the activation level. The study, planned as a descriptive and experimental type, is an attempt to increase the activation level of…
- Conditions
- Diabetes Mellitus (DM), Type 2 Diabetes Mellitus (T2DM), Patient Activation, Diabetes Self-management
- Trial name
- NCT06973954
- Testing
- Text Message Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Breast Cancer Risk, Cardiovascular Disease Risk
The RISC Registry--Risk Informed Screening Registry
Chronic diseases such as heart disease, cancer, and diabetes are the leading causes of death and disability in the United States. Six in ten adults have one chronic disease; 4 in 10 have two or more.
- Conditions
- Breast Cancer Risk, Cardiovascular Disease Risk, Cardiometabolic Risk, Diabetes
- Trial name
- RISC (NCT05848856)
- Testing
- Breast Cancer, Cardiometabolic, Cardiovascular Risk Screening and Follow up
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Precision Health Equity Initiative
Diabetes
Safety and Viability of an E. Coli Nissle Colibactin Knockout in Healthy Volunteers
E. coli Nissle (EcN) is a well-established human probiotic. However, it has been found that it produces colibactin, linked to colorectal cancer.
- Trial name
- SECONI (NCT05816577)
- Testing
- EcN Colibactin knockout, E Coli Nissle
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Max Nieuwdorp
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Role of Fasted Exercise on Improving Cardiometabolic Health
The aim of this randomised control trial is to investigate the role of fasted exercise on cardiometabolic health. Participants will be assigned to one of three conditions, fasted exercise, fed exercise and control (no exercise).
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT05742373
- Testing
- Exercise training in the fasted state, Exercise training in the fed state
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Type 2 Diabetes Mellitus
ECC5004 RBA FE Study in Healthy Participants
This study is a Phase 1, open-label, randomized, single dose, fixed sequence, crossover study designed to compare the relative bioavailability of 50 mg ECC5004 current tablet formulation (F1) and 50 mg ECC5004 new tablet…
- Trial name
- NCT06268145
- Testing
- ECC5004
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Eccogene
Periampullary Neoplasms, Pancreatic Cancer
Cohort Study on Nutritional, Metabolic, and Volumetric Assessment After Pancreaticoduodenectomy
Periampullary malignant neoplasms are among the most lethal gastrointestinal tumors. They are usually diagnosed at advanced stages and require complex surgical treatment.
- Conditions
- Periampullary Neoplasms, Pancreatic Cancer, Pancreaticoduodenectomy
- Trial name
- NCT07159672
- Testing
- Pancreaticoduodenectomy
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Marco Aurélio Ribeiro, PhD
Obesity, Diabetes
Time Restricted Feeding and Metabolic Rhythms
Current guidelines for the prevention and treatment of obesity focus on caloric restriction diets and increasing physical activity, but long-term compliance to these strategies is poor.
- Trial name
- Rhythm (NCT04009239)
- Testing
- Time Restricted Feeding
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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