Clinical trials: Endocrine Disorder
Diabetes
A Computer-Based Simulation of DKA Management
A 2-by-2 factorial cluster randomized controlled trial was performed to: 1) Compare the effects of supervised (coached) versus unsupervised (no coach) administration of the DKA simulator on trainees' knowledge of DKA management…
- Trial name
- DKA (NCT02799563)
- Testing
- Coach, Preselected number of cases, Coach, Self-selected number of cases, No coach, Preselected number of cases
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
Comparative Glucose Clamp Study of Wockhardt's Insulin Human Regular for Injection and Novolin R, in Healthy Subjects.
The purpose of this study is the comparative evaluation of the pharmacokinetics and pharmacodynamics of two recombinant regular human insulin injections administered subcutaneously in healthy volunteers under the conditions of…
- Trial name
- NCT00596063
- Testing
- Wosulin R, Novolin R
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wockhardt
Diabetes Mellitus
Study Of Single Ascending Doses Of PBL 1427 In Healthy Volunteers
PBL 1427 is a Dipeptidyl peptidase (DPP)-IV inhibitor being developed for treatment of type 2 diabetes. Although a number of DPP-IV inhibitors have been described, there still exists a need for new DPP-IV inhibitors that have…
- Trial name
- NCT01554293
- Testing
- PBL 1427 capsules
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Panacea Biotec Ltd
Diabetic Retinopathy
Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography
The purpose of this study is to identify alterations of the blood-retinal barrier (BRB) in diabetic retinas using a novel non-invasive approach based on the Fourier domain high-definition optical coherence tomograph (OCT).
- Trial name
- CNTM025A OCT (NCT01220804)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Heart Failure, Type 2 Diabetes
Transform: Teaching, Technology, and Teams
This initiative supports a quality improvement effort evaluating the use of strategies (including technology-based decision support, referral to a virtual GDMT team, and general educational tools/resources for clinicians and…
- Conditions
- Heart Failure, Type 2 Diabetes, Atrial Fibrillation
- Trial name
- T3 (NCT05572814)
- Testing
- Decision Support, Referral
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- American College of Cardiology
Insulin Resistance, Diabetes Mellitus, Type 2
New IR Biomarkers (Myokines) in Colombian People
Around the world, the prevalence of type 2 diabetes mellitus (T2DM) has been increasing since the last two decades, with approximately 347 million patients with diabetes by 2013 according to the World Health Organization (WHO).
- Trial name
- NCT03244449
- Testing
- No apply
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Los Andes, Columbia
Diabetes, Exercise Physiology
Elevated FFA and Skeletal Muscle Lipid Content
There is increasing evidence that skeletal muscle lipid content (IntraMyoCellular Lipid, IMCL) markedly increases the risk of metabolic complications, including insulin resistance and cardiovascular events.
- Trial name
- NCT01906333
- Testing
- Exercise, Glucose, Fasted
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Dental Implant Surgical Techniques, Diabetes Mellitus
Effect of Diabetes on Short İmplants in One- and Two-Stage Surgeries
The goal of this clinical trial is to compare one- and two-stage techniques for short implant surgery in diabetes. The main questions it aims to answer are: Is one-stage short implant surgery at risk of implant osseointegration…
- Conditions
- Dental Implant Surgical Techniques, Diabetes Mellitus, Short Dental Implants
- Trial name
- NCT06243276
- Testing
- One stage implant surgery, Two stage implant surgery
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Erzincan University
Gestational Diabetes Mellitus (GDM)
The Impact of Robot-assisted Digital Education on Prenatal Women's Health Literacy
This randomized controlled trial evaluates the effectiveness of a robot-assisted digital education program for pregnant women diagnosed with gestational diabetes mellitus (GDM).
- Trial name
- RADE (NCT06999421)
- Testing
- Robot with interactive animations, gesture recognition, and touch/voice-based input, Standard tablet (video playback only).
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Peripheral Artery Disease
Genetics of Peripheral Artery Genomics
Peripheral artery disease is a disease that contributes to significant morbidity and mortality of millions of Americans yearly. Very little is known about the pathophysiology of atherosclerosis in peripheral artery disease.
- Trial name
- NCT00615121
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 2 Diabetes, Prediabetes
Sweet Sensing in Type 2 Diabetes
Diabetes is a global challenge and the number of people affected by diabetes is expected to rise to 5.5 million by 2030, of which 90% are type 2 diabetes (T2D).
- Trial name
- NCT06804187
- Where
- United Kingdom
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type 2 Diabetes
Metabolic Benefits of Drinking Blueberry Tea in Type 2 Diabetes
Plant derived compounds, e.g. flavonoids from dark chocolate, green tea, or blueberries, show great potential as nutraceuticals for the treatment of various diseases such as type 2 diabetes (T2D).
- Trial name
- NCT02629952
- Testing
- Blueberry Tea
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
PreDiabetes, Insulin Sensitivity
Exercise Intervention for the Prevention of Prediabetes in Overweight Chinese
Overweight/obese Chinese and prediabetes will be recruited and divided into three age-matched groups including high intensity exercise, moderate intensity exercise, and non-exercise groups.
- Trial name
- NCT03240978
- Testing
- exercise intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Diabetes
Pharmacogenetics of Response to Sitagliptin (PRS)
This is a research study to find out how different people respond to a medication called sitagliptin. Sitagliptin is an FDA approved medication that is used to treat diabetes.
- Trial name
- PRS (NCT06813014)
- Testing
- Oral Glucose Tolerance Test
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Urinary Tract Infection, Diabetes Mellitus
Preliminary Testing of the Vitaliti CVSM Wearable, Vitaliti Spirotoscope, and Vitaliti IVD Station
The study objective is to satisfy the testing requirements for the Qualcomm Tricorder XPRIZE Competition. This requires an oversight model using the Vitaliti CVSM Wearable, Vitaliti Spirotoscope, and Vitaliti IVD Station to…
- Conditions
- Urinary Tract Infection, Diabetes Mellitus, Atrial Fibrillation, OSA
- Trial name
- NCT02856633
- Testing
- Vitaliti
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cloud DX Inc.
Pregnancy, Postpartum
HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children
Regular exercise during pregnancy and postpartum leads to health benefits for mother and child. Inactivity during pregnancy and after delivery is now treated as risky behavior.
- Conditions
- Pregnancy, Postpartum, Childbirth, Health Status
- Trial name
- HIIT MAMA (NCT05009433)
- Testing
- High intensity interval training program for pregnant women, Moderate intensity continuous training program for pregnant women, Standard obstetric care with extended education on healthy lifestyle
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Thyroid Cancer
Famitinib in Combination With Adebrelimab for the Treatment of Advanced Thyroid Cancer
This is a multi-cohort, open-label, single-centre, Phase 2 study aiming to investigate the efficacy and safety of a regimen using the multi-targeted kinase inhibitor Famitinib in combination with the PD-L1 antibody Adebrelimab…
- Trial name
- NCT06146985
- Testing
- 20 mg Famitinib & 1200 mg Adebrelimab
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Diabetes Mellitus
Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers
The current study was conducted to evaluate the prognostic implications of vitamin B12 admission on BMI and HbA1c levels in type 2 diabetic patients treated with Dapagliflozin as a routine medication.
- Trial name
- NCT06241638
- Testing
- Vitamin B12 0.5 MG/ACTUAT, Dapagliflozin 10mg Tab
- Where
- Jordan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Al-Balqa Applied University
Diabetes, Type I
Prevention of Clinical Onset of Type 1 Diabetes in High Risk First Degree Relatives
Prophylactic administration of metabolically active insulin can prevent or delay clinical onset of diabetes in a high risk group of nondiabetic siblings as defined by positivity for autoantibodies against IA-2 (IA-2-A).
- Trial name
- NCT00654121
- Testing
- Actrapid HM
- Where
- 3 sites in Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Healthy, Men
Metabolic Availability of Lysine From Wheat in Adult Men
Protein is the key determinant of growth and bodily functions. The quality of food proteins depend on their amino acid content and the amount of amino acids used by the body to make proteins.
- Trial name
- NCT03200652
- Testing
- Metabolic availability of lysine in wheat
- Where
- Canada
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
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