Clinical trials: Endocrine Disorder
Type 1 Diabetes, Diabetes in Children
The T1D Parent Check-In: A Preventative Intervention
The goal of this clinical trial is to learn how to best support families during the first year of a child or teen's Type 1 diabetes (T1D) diagnosis.
- Trial name
- NCT06160934
- Testing
- T1D Parent Check-in
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Diabetes, Implant Site Reaction
Laser Biostimulation on Implant Covered With PRF in Controlled Diabetics
the goal of this clinical trial is to evaluate laser biostimulation effect on osseointegration of implant covered by PRF(platelet rich fibrin) in controlled diabetic patients with compromised healing potential.
- Conditions
- Diabetes, Implant Site Reaction, Platelet Rich Fibrin
- Trial name
- PRF (NCT06444334)
- Testing
- low level Diode Laser, PRF platelet rich fibrin
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- National Research Centre, Egypt
Pituitary Macroadenoma
Radioactive Iodine Implants for Pan-invasive Pituitary Macroadenomas
This study is a single arm Phase II pilot trial. Patients enrolled on the trial will undergo implantation of high activity iodine-125 seeds into their pituitary adenoma.
- Trial name
- NCT01444209
- Testing
- Iodine Implants
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 1, Type 1 Diabetes
"FEXIS": (Feasibility of an Extended Wear CSII Set in Participants With T1DM)
Over 1 million patients globally currently manage their Type 1 Diabetes mellitus using continuous subcutaneous insulin infusion with an infusion set that needs to be changed every 3 days.
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Type 1 Diabetes Mellitus, Diabetes Mellitus, Insulin-Dependent, 1
- Trial name
- FEXIS (NCT04503564)
- Testing
- coil-reinforced soft polymer indwelling cannula
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Capillary Biomedical, Inc.
Type 2 Diabetes
A Study of ZT002 Injection in Adult Chinese Subjects With Type 2 Diabetes Mellitus (T2DM)
This study will comprise a randomized, double blind, placebo controlled, multiple ascending dose, safety, tolerability and pharmacokinetic study of ZT002 in subjects with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT07065032
- Testing
- ZT002 Injection
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Advanced Cancers
Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)
The goal of this clinical research study is to find the highest tolerable doses of the combinations of lenalidomide and other drugs that can be given to patients with advanced cancer.
- Trial name
- NCT01183663
- Testing
- Lenalidomide, Bevacizumab, Sorafenib
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- M.D. Anderson Cancer Center
Recurrent Cervical Cancer, Recurrent Ovarian Epithelial Cancer
Phase I Study of Intravenous Triapine (IND # 68338) in Combination With Pelvic Radiation Therapy With or Without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies
Drugs used in chemotherapy, such as 3-AP and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Recurrent Cervical Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Vaginal Cancer, Recurrent Vulvar Cancer
- Trial name
- NCT00335998
- Testing
- triapine, laboratory biomarker analysis, external beam radiation therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Pancreatic Cancer, PDAC
ACCENT: AMP945 in Combination With Nab-paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer
This is a multicentre, open label, two-part study to determine whether the focal adhesion kinase (FAK) inhibitor AMP945, when given prior to dosing with gemcitabine and nab-paclitaxel, improves response to therapy in first-line…
- Conditions
- Pancreatic Cancer, PDAC, Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT05355298
- Testing
- AMP945 ascending doses, AMP945 RP2D
- Where
- 13 sites in Australia, South Korea
- Volunteers
- 62 people
- Sponsor
- Amplia Therapeutics Limited
Diabetes Mellitus, Non-Insulin-Dependent, Hypertriglyceridemia
PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA
The primary objective of the study is to contrast the pharmacokinetic profiles of metformin and EPA delivered separately as co-administered products (metformin hydrochloride or Glucophage and icosapent ethyl or Vascepa) and…
- Trial name
- NCT02113163
- Testing
- Metformin Eicosapentaenoate, Metformin HCl and Vascepa
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Thetis Pharmaceuticals LLC
Diabetes Mellitus, Type 1
A Multiple Dose Study Investigating Pharmacokinetics and Pharmacodynamics of Subcutaneous NNC0363-0845 in Participants With Type 1 Diabetes Pharmacokinetics and Pharmacodynamics: How Insulin NNC0363-0845 is Transported Throughout the Body and How It Works
This study is designed to investigate the movement of insulin NNC0363-0845 throughout the body and how it works for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT05134987
- Testing
- NNC0363-0845, Insulin detemir
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Novo Nordisk A/S
Pancreatic Cancer, Adult, Cephalic Duodenopancreatectomy
Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study
Malnutrition is a common challenge in patients with pancreatic cancer undergoing cephalic pancreaticoduodenectomy (CPD), impacting postoperative recovery and overall prognosis.
- Trial name
- NCT06852014
- Testing
- Dietary Supplement: Experimental Treatment with nutritional suplement A + nutritional suplement B, Dietary Supplement: Dietary Supplement: Experimental Treatment with nutritional suplement B + nutritional suplement A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Diabetes Mellitus, Renal Impairment
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood…
- Trial name
- BIOMARKERS (NCT00948116)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Barts & The London NHS Trust
Metabolic Syndrome, Overweight or Obesity
Impact of Time-Restricted Eating on Metabolic Homeostasis, Inflammation and Oxidative Stress in Metabolic Syndrome
The main purpose of the clinical trial is to determine the health impact of a dietary intervention known as time-restricted eating (TRE) in patients with metabolic syndrome (defined as the presence of elevated fasting plasma…
- Conditions
- Metabolic Syndrome, Overweight or Obesity, PreDiabetes, Weight Loss
- Trial name
- TREMNIOS (NCT04328233)
- Testing
- Time-Restricted Eating
- Where
- Poland
- Volunteers
- 27 people
- Sponsor
- Nicolaus Copernicus University
Cardiovascular Diseases, Coronary Disease
Framingham Cycle V Offspring-Spouse Nutrition Studies
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005347
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pancreas Cancer, Pancreatic Adenocarcinoma
Dissecting the Pattern of Nodal Spread in Post-neoadjuvant Pancreatoduodenectomy
There has been long-standing debate about nodal dissection in pancreatoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC), with most studies examining the value of nodal yields, number of metastatic nodes and spatial…
- Trial name
- NCT06135649
- Testing
- Systematic lymphadenectomy
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- Universita di Verona
Advanced Solid Malignancies, Non-small Cell Lung Cancer (NSCLC)
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
The purpose of this study is to evaluate the safety, tolerability, and efficacy of BMS-986523 alone and in combination with anti-cancer agents in participants with advanced solid malignancies
- Conditions
- Advanced Solid Malignancies, Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC)
- Trial name
- NCT07223047
- Testing
- BMS-986523, Gemcitabine, Nab-Paclitaxel
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 252 people
- Sponsor
- Bristol-Myers Squibb
Overweight, Diabetes Type 2
The Efficacy of Bariatric Surgery Compared to Medical Therapy in Controlling Type2 Diabetes Mellitus in Patients With Non Morbid Obesity.
The growing incidence of obesity and type2 DM globally is widely recognized as one of the most challenging contemporary threats to public health.
- Trial name
- NCT02036138
- Testing
- Laparoscopic Sleeve Gastrectomy, Laparoscopic Roux-en-Y Gastric Bypass, Advanced Medical Therapy
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Hadassah Medical Organization
Diabetes Mellitus
Pharmacist-driven CGM Use in the Uninsured Population
This is a pilot study. The purpose is to (1) provide access to continuous glucose monitoring (CGM) to patients (purchased through a grant) and (2) systematically record and analyze the results of the glucose monitoring by the…
- Trial name
- NCT03477838
- Testing
- FreeStyle LibrePro CGM
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Effectiveness and Safety Study of the Abbott Sensor Based Glucose Monitoring Systems
The purpose of the study is to evaluate the safety and effectiveness of the Abbott Sensor Based Glucose Monitoring System Personal (System-P) and Abbott Sensor Based Glucose Monitoring System Professional (System-Pro) when used…
- Trial name
- NCT02283411
- Testing
- Abbott Sensor Based Glucose Monitoring System
- Where
- 6 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Abbott Diabetes Care
Prediabetes, Type 2 Diabetes
Pathobiology and Reversibility of Prediabetes in a Biracial Cohort
The reasons for the epidemics of diabetes and prediabetes, and why individuals from certain populations suffer at higher rates are not well known.
- Conditions
- Prediabetes, Type 2 Diabetes, Obesity
- Trial name
- PROP-ABC (NCT02027571)
- Testing
- Intensive Lifestyle Intervention (ILI)
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Tennessee
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