Clinical trials: Endocrine Disorder
Diabetes Mellitus Type 2, Hypertension
Mobile Sipoo - Telemonitoring With Combined With Active Assistance Technology
Mobile Sipoo is a randomized controlled trial aiming to improve selfcare and outcomes of diabetes and hypertensive patients by introducing a remote patient monitoring system supported with automatic patient decision support.
- Trial name
- NCT01547156
- Testing
- Intervention group
- Where
- Finland
- Volunteers
- 56 people
- Sponsor
- VTT Technical Research Centre of Finland
Gastrointestinal Cancer, Colorectal Cancer
Exercise to Reduce Chemotherapy-Induced Peripheral Neuropathy
This randomized, controlled, pilot experiment will evaluate the effects of an aerobic walking intervention on OIPN (oxaliplatin-induced peripheral neuropathy) in patients with gastrointestinal (GI) cancer who are already…
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Cancer, Gastric Cancer
- Trial name
- NCT03515356
- Testing
- MI-Walk Intervention, Physical Activity Education Pamphlet
- Where
- 7 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Michigan Rogel Cancer Center
Neoplasms, Pancreatic
First-time-in-human (FTIH) Study of GSK3145095 Alone and in Combination With Other Anticancer Agents in Adults With Advanced Solid Tumors
In an unbiased CRISPR screen, RIPK1 was identified as a top gene contributing to immunotherapy resistance. In addition, RIPK1 has been reported to drive pancreatic oncogenesis.
- Trial name
- NCT03681951
- Testing
- GSK3145095, Pembrolizumab
- Where
- 6 sites in United States
- Volunteers
- 8 people
- Sponsor
- GlaxoSmithKline
Obesity, Diabetes
Comparison of Pulse Chips and Commercial Snacks on Food Intake, Appetite and Blood Glucose in Healthy Young Adults
Consumers are often forced to eat fast, convenient foods and snacks ("eat on the go") in order to match the pace of their lifestyles. However, these snack options more often than not offer little health benefit to the consumer.
- Trial name
- NCT03297931
- Testing
- Corn Chips + Onion Dip, Yellow pea chip + hummus, Pinto bean chip + hummus
- Where
- Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Type 2 Diabetes
Impacts of Intermittent Fasting on Energy Balance and Associated Health Outcomes
Obesity is a global concern with links to conditions such as diabetes. Historically, these conditions have been managed by reducing energy intake on a daily basis, which is often hampered by low adherence rates and compensatory…
- Trial name
- NCT02498002
- Testing
- Physical Activity Monitoring (Actiheart), Energy Intake Monitoring, Body Weight Monitoring
- Where
- United Kingdom
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Bath
Diabetes Mellitus, Type 2, Coronary Artery Disease
Optimizing Audit and Feedback for Primary Care
There remains a large gap between ideal and actual care provided to patients with chronic diseases. Performance feedback reports are often used as a foundation for quality improvement interventions.
- Trial name
- NCT00996645
- Testing
- Worksheet to facilitate goal-setting and action plans
- Where
- Canada
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Overweight, Diabetes
Functional Ingredients: Effect in Gastrointestinal System
The addition of fructans or unripe banana flour to frozen meals can change the hormonal parameters related to hunger and satiety, improve the bowel movements and increase in colonic bacteria population measured by microbiological…
- Conditions
- Overweight, Diabetes, Constipation
- Trial name
- NCT02467972
- Testing
- Ready-to-eat frozen soups added unripe banana flour, Ready-to-eat frozen soups added maltodextrin, Ready-to-eat frozen soups added inulin
- Where
- Brazil
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 2, Obesity
Culturally Adapted Dietary Clinical Trial in PR
This project will determine whether a diet culturally adapted to adults in Puerto Rico can effectively decrease cardiometabolic risk factors.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- PRECISION (NCT05962372)
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Diabetes Mellitus, Type 2
Glucose and Activity Tracking for Sedentary Behavior Interventions in Older People With Type 2 Diabetes (TRACK T2D)
The overarching goal of this explanatory mixed methods study is to evaluate how older people living with type 2 diabetes (T2D) integrate continuous glucose monitor (CGM) and activity data in diabetes self-management, and how this…
- Trial name
- NCT07524205
- Testing
- SB Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Prediabetes, Overweight , Obesity
Exercise, Chronotype, and Prediabetes
The goal of this clinical trial is to find out whether exercising at the right time of day, based on a person's natural body clock, leads to greater health benefits in people living with prediabetes.
- Trial name
- NCT07389005
- Testing
- Timing of exercise, Control
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- German Diabetes Center
Ovarian Cancer
Innovative Ovarian Cancer Biomarker Assays
Ovarian cancer is often diagnosed at a later stage because early symptoms can be mild or non-specific. Earlier detection of ovarian cancer could improve treatment options and outcomes.
- Trial name
- DISARM CSB (NCT07693894)
- Testing
- Investigational ovarian cancer biomarker assays
- Where
- 7 sites in Czechia, Greece and 3 more
- Volunteers
- 2,080 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Type 2 Diabetes
Single Ascending Dose Study With Healthy Male Volunteers and Type II Diabetic Patients
The purpose of this study is to assess safety and tolerability of AZD6714 after single ascending oral doses in healthy male subjects and type 2 diabetic patients.
- Trial name
- NCT00886366
- Testing
- AZD6714
- Where
- Sweden
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Type 2 Diabetes
A Registry-based Randomized Controlled Trial in Type 2 Diabetes With Cardiovascular Risk Factors (REMATCH)
Glycemic control is a mainstay of diabetes management to reduce the risk of microvascular complications and cardiovascular outcomes in people with type 2 diabetes (T2D).
- Trial name
- REMATCH (NCT06627322)
- Testing
- Dual-combination therapy, Triple-combination therapy, Dexcom G7, Pasta
- Where
- 2 sites in South Korea
- Volunteers
- 5,950 people
- Sponsor
- Kyu Chang Won
Diabetic Foot, Health Behavior
Manipulating Narrative Presentations of Information to Encourage Good Foot Care Practice in People With and Without Diabetes Mellitus
The study explores the role of health messages (narrative, non-narrative vs. control condition [no message]) to enhance good foot care practices among people with diabetes and the general population.
- Conditions
- Diabetic Foot, Health Behavior, Foot Diseases
- Trial name
- NCT04623151
- Testing
- Online leaflet about foot care
- Where
- United Kingdom
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of Chichester
Type 2 Diabetes Mellitus, Mild Cognitive Impairment
LIGHT-MCI Trial: GLP-1 Agonist, SGLT2 Inhibitor, and DPP-4 Inhibitor for MCI Remission in Type 2 Diabetes
This is an investigator-led prospective, randomized, open label, parallel study to explore and evaluate the therapeutic effects of Liraglutide, Empagliflozin and Linagliptin on the cognitive function in T2DM patients with mild…
- Trial name
- LIGHT-MCI (NCT05313529)
- Testing
- Liraglutide, Empagliflozin, Linagliptin
- Where
- 5 sites in China
- Volunteers
- 396 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Fallopian Tube Cancer, Peritoneal Cavity Cancer
Cyclophosphamide With or Without Celecoxib in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
- Trial name
- NCT00538031
- Testing
- cyclophosphamide, celecoxib
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- City of Hope Medical Center
Erectile Dysfunction, Stem Cells
Intracavernous Injection of Autologous Mesenchymal Stem Cells in the Treatment of Erectile Dysfunction Resistant to Oral Treatment in Patients With Type I Diabetes
Diabetes is a major concern in public health because of its high frequency and its negative consequences. Erectile dysfunction (ED) is present, regardless of age, in 50 to 75% of men with diabetes.
- Conditions
- Erectile Dysfunction, Stem Cells, Diabetes Mellitus, Type 1
- Trial name
- MESERIC (NCT03361631)
- Testing
- Autologous Bone Marrow derived Mesenchymal Stem Cells
- Volunteers
- 13 people
- Sponsor
- Central Hospital, Nancy, France
Acromegaly
Efficacy and Safety of Octreotide Capsules (MYCAPSSA) in Acromegaly
Octreotide capsule is a novel, orally-administered formulation of the commercially-available injectable drug octreotide. In a recent phase 3 trial, oral octreotide capsules demonstrated maintenance of biochemical response up to…
- Trial name
- OPTIMAL (NCT03252353)
- Testing
- octreotide capsules
- Where
- 60 sites in United States, Australia and 15 more
- Volunteers
- 56 people
- Sponsor
- Chiasma, Inc.
Dental Implant, Diabetes
Stability and Crestal Bone Changes Around Implants Placed at Crestal Versus Subcrestal Level in Controlled Type Two Diabetic Patients
The objective of this study is to assess clinically the peri implant tissues, the radiological marginal bone loss and the stability around implants placed at the crestal versus the subcrestal level in type 2 controlled diabetic…
- Trial name
- NCT05125445
- Testing
- Implants placed at bone crest, Implants placed 1mm Subcrestally
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Hams Hamed Abdelrahman
Healthy, Type 1 Diabetes
Subcutaneous Administration of Lisofylline to Healthy Normal Subjects and Subjects With Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Autoimmune diseases happen when the immune system does not identify part of the body as belonging to it.
- Trial name
- NCT00896077
- Testing
- Lisofylline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- DiaKine Therapeutics, Inc.
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