Clinical trials: Endocrine Malignancy
Polycystic Ovary Syndrome, Vitamin D Deficiency
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
The purpose of this study is to investigate the mechanism that explain the beneficial clinical effect of vitamin D treatment in women with PCOS.
- Trial name
- NCT03644212
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Maimonides Medical Center
Narrative Medicine, Chronic Disease
Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students
A qualitative study assessing the impact of early narrative medicine practice on Medical Honors Program (MHP) students' attitudes regarding patient-centered interactions, through interviewing patients with chronic or…
- Conditions
- Narrative Medicine, Chronic Disease, Terminal Illness, Cancer
- Trial name
- NCT03041571
- Testing
- Patient Provider Orientation Scale, Interview performed by MHP student
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Ovarian Cancer
Evaluation of Polygenic Risk Score for Epithelial OVarian cancEr Risk Prediction: the PROVE Study
The goal of this observational study is to evaluate whether polygenic risk score (PRS) assessment can help predict the onset of epithelial ovarian cancer in women aged over 18, comparing those with a histologically confirmed…
- Trial name
- PROVE (NCT06935344)
- Testing
- Polygenic Risk Score, Biopsy on normal contralateral ovary, Pharmacogenetic profiles
- Where
- Italy
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Polycystic Ovary Syndrome
Adipocytokines and Polycystic Ovary Syndrome (PCOS)
Inflammation may play a role in the development of polycystic ovary syndrome (PCOS). In this study, the investigators investigated the expression of different mediators of inflammation in fatty tissue and in blood in women with…
- Trial name
- NCT00975832
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Polycystic Ovary Syndrome, Infertility
Graceful Lifestyle Changes Study for PCOS and Infertility
The purpose of this study is to help women with PCOS to improve their symptoms and ovulation rate through a lifestyle intervention program which introduces a specific diet, a physical activity regimen and mindfulness exercises to…
- Trial name
- GLC (NCT02630485)
- Testing
- Graceful Lifestyle Changes, Myo-inositol, Letrozole
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cancer
Pilot Study With the Aim to Quantify a Stress Protein in the Blood and in the Urine for the Monitoring and Early Diagnosis of Malignant Solid Tumors
Recent studies shows that extracellular vesicles (named "exosomes") released by cancer cells exhibit at their membrane the stress protein HSP70, contrary to exosomes released by normal cells.
- Trial name
- EXODIAG (NCT02662621)
- Testing
- blood samples, Urine samples
- Where
- France
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Georges Francois Leclerc
Ovarian Cyst
Single Versus Conventional Laparoscopy for Benign Adnexal Disease
Keyhole surgery for adnexal disease has traditionally been performed using three or four small incisions. The last years a new operating method has been introduced.
- Trial name
- NCT01288599
- Testing
- Laparoscopic surgery
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Polycystic Ovary Syndrome
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome
The primary objective is to determine if meals of different fat and fiber content affect postprandial plasma testosterone concentration in women with polycystic ovary syndrome.
- Trial name
- NCT00455338
- Testing
- Meal Composition
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ovarian Epithelial Cancer, Carcinoma in Situ
Lavage of the Uterine Cavity for the Diagnosis of Serous Tubal Intraepithelial Carcinoma
The current study aims at answering the scientific question, whether exfoliated cells from STICs get transported into the uterine cavity via the fallopian tube, and whether it is possible to detect those cells in the lavage fluid…
- Conditions
- Ovarian Epithelial Cancer, Carcinoma in Situ, Ovarian Cancer
- Trial name
- LUSTIC (NCT02039388)
- Testing
- Lavage of the Cavum uteri and proximal Fallopian tubes, performed in the luteal phase of the female cycle
- Where
- 14 sites in Austria, Belgium and 6 more
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pancreatic Cancer, Thyroid Nodule
A Study of Multiparametric Ultrasound Imaging Methods
The researchers are doing this study to see how well a type of ultrasound imaging called multiparametric ultrasound (mpUS), can be used to examine, evaluate, and provide information about different cancerous and non-cancerous…
- Trial name
- NCT07270237
- Testing
- Multiparametric ultrasound (mpUS) imaging
- Where
- 7 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreatic Adenocarcinoma
Prospective Evaluation of MRI Biomarkers in Pancreatic Ductal Adenocarcinoma
This is a prospective cohort study in participants with pancreatic adenocarcinoma who are undergoing surgical resection. Participants will have up to two magnetic resonance imaging (MRI) scans with and without intravenous…
- Trial name
- NCT02775786
- Testing
- MRIs with and without intravenous contrast (up to 2)
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Columbia University
Liver Cancer, Biliary Tract Cancer
Early-stage Detection of LIver, Biliary TRAct and PancReatic Cancers
LIBRARY is a prospective, multi-center, observational study aimed at detecting early liver, biliary tract, and pancreatic cancers by combining assays of cell-free DNA (cfDNA) methylation, serum protein, and microRNA.
- Conditions
- Liver Cancer, Biliary Tract Cancer, Pancreatic Cancer
- Trial name
- NCT06139042
- Testing
- Blood drawing
- Where
- China
- Volunteers
- 1,608 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Polycystic Ovary Syndrome
Oral Contraceptive and Cardiovascular Risk in PCOS
Oral contraceptive therapy is routinely used for the treatment of menstrual disturbances of patients with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00593294
- Testing
- Physical exercise, OC - Drospirenone plus Ethynylestradiol, Vitamin, polyvitamins tablets
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
Gastric Cancer, Pancreatic Cancer
Chemoradiation-Induced Nausea and Emesis: Quality of Life
The primary objectives of this study are: 1. To assess the preferences of cancer patients scheduled to receive chemoradiation and caregiver controls for side-effects of chemoradiation. 1.
- Conditions
- Gastric Cancer, Pancreatic Cancer, Cervical Cancer, Vulvar Cancer
- Trial name
- NCT00394602
- Testing
- Interview, Questionnaire
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Pancreatic Cancer
B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
The goal of this clinical trial is to develop a new cancer diagnostic and prognostic tool based on the dynamic and non-invasive detection of an exogenous volatile molecule, i.e., ethanol, from patients' samples.
- Conditions
- Breast Cancer, Pancreatic Cancer, Pulmonary Cancer, Volatile Organic Compound
- Trial name
- B-GLUCANCER2 (NCT07236177)
- Testing
- blood plasma sample, blood sampling
- Where
- France
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Uterine Fibroids, Adenomyosis
Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy
The aim of this RCT of study is to compare the standard TLH with adnexal preservation with TLH plus prophylactic bilateral salpingectomy (PBS) in terms of ovarian reserve and surgical outcomes
- Conditions
- Uterine Fibroids, Adenomyosis, Pelvic Pain, Pelvic Prolapse
- Trial name
- NCT02086344
- Testing
- PBS, TLH _adnexal preservation
- Where
- Italy
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University Magna Graecia
Polycystic Ovary Syndrome, Hyperandrogenism
Urinary DENND1A.V2 as a Predictor of Pubertal Hyperandrogenemia
Polycystic ovary syndrome (PCOS) is a common disorder marked by hyperandrogenism, oligo-/anovulation, and subfertility. The precise causes of PCOS are unclear, but the pathophysiology involves complex genetic and environmental…
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Puberty
- Trial name
- DENND1A (NCT02611128)
- Testing
- Phenotype/genotype assessment
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Effects of Chemotherapy
Assessing Fertility Potential in Female Cancer Survivors
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers.
- Trial name
- NCT01143844
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Polycystic Ovary Syndrome (PCOS)
14 Weeks Exercise Training on Lean Women With and Without PCOS
The aim of this project is to investigate the pathophysiology of PCOS in regards to the metabolic profile including defects in insulin sensitivity in skeletal muscle and adipose tissue, and to investigate the effects of exercise…
- Trial name
- NCT02429128
- Testing
- 14 weeks exercise training
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
HIV Infections, Men
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two…
- Conditions
- HIV Infections, Men, Treatment Adherence
- Trial name
- NCT05602376
- Testing
- U=U testing messaging scripts, U=U adherence messaging scripts
- Where
- 2 sites in South Africa
- Volunteers
- 3,642 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
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