Clinical trials: Endocrine Malignancy
Osteoporosis, Hypercalcemia of Malignancy
One Week Comparison Study of PTH and PTHrP Infusions
This is a dose escalation study to determine the maximum tolerable dose of Parathyroid Hormone-related Protein, PTHrP, or Parathyroid Hormone, PTH, that can be given safely over one week in healthy African-American volunteers.
- Conditions
- Osteoporosis, Hypercalcemia of Malignancy, Hyperparathyroidism, Bone Diseases, Endocrine
- Trial name
- NCT01333267
- Testing
- Parathyroid Hormone-related Protein (1-36), parathyroid hormone (1-34), PTH (1-34) and PTHrP (1-36)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pittsburgh
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
Changes in Serum, Follicular Fluid SREBP1c and LRG1 Levels in PCOS Patients and Correlation With Insulin Resistance
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disease that affects 6-20% of women of childbearing age worldwide.
- Trial name
- NCT06066034
- Testing
- HOMA-IR，ESHRE/ASRM
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gui Xiaoting
Cardiovascular Diseases, Cardiotoxicity
Cancer Treatment Related Cardiovascular Toxicity: Comprehensive Myocardial and Vascular Phenotyping
Observational prospective cohort study designed to assess the mechanisms of fluoropyrimidine induced cardiovascular toxicity.
- Conditions
- Cardiovascular Diseases, Cardiotoxicity, Fluorouracil Adverse Reaction, Malignancy
- Trial name
- PC-TOX (NCT06048458)
- Testing
- Cardiovascular magnetic resonance with stress perfusion, CT coronary angiography, Retinal OCT angiography
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Pancreatic Ductal Adenocarcinoma
Early Detection of Pancreatic Adenocarcinoma (PDAC) Using a Panel of Biomarkers
Urine and blood samples are being collected from patients with and without diseases of the pancreas. These samples will be tested with the aim of developing an accurate way of diagnosing diseases of the pancreas using the results.
- Trial name
- UroPanc (NCT04449406)
- Where
- 4 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Polycystic Ovary Syndrome
Plant Exosomes and Patients Diagnosed With Polycystic Ovary Syndrome (PCOS) 17
The purpose of this study is to see if substances contained in ginger or aloe plants, called exosomes, will treat and improve the condition polycystic ovary syndrome
- Trial name
- NCT03493984
- Testing
- Ginger exosomes, Aloe exosomes
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Louisville
Leukemia, Myeloid, Acute, Leukemia, B-cell
Precision Exercise in Children With Malignant Hemopathies
In the early years of life and during adolescence, physical activity is crucial for good development of motor skills. It is even more so for those children and young people who are forced to undergo anti-cancer therapies and…
- Conditions
- Leukemia, Myeloid, Acute, Leukemia, B-cell, Leukemia, T Cell, Lymphoma, Hodgkin
- Trial name
- SportTherapy (NCT04090268)
- Testing
- Sport Therapy
- Where
- Italy
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Milano Bicocca
Oral Microbiome, Pancreatic Cancer
Pancreatic Cancer and Oral Microbiome
Pancreatic cancer (PC) is a solid malignancy with a dismal prognosis. It has a 5-year survival rate of approximately 8%. This is due to the usually late diagnosis, to chemoresistance, and to intrinsic biological aggressiveness.
- Conditions
- Oral Microbiome, Pancreatic Cancer, IPMN, Parodontopathy
- Trial name
- NCT04993846
- Testing
- Dental plaque sampling, qPCR
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma
Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals
The purpose of this research is to see if adding blood-based tests and symptom review to standard-of-care pancreatic cancer screening procedures can identify cancer early among individuals with increased risk.
- Conditions
- Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06122896
- Testing
- Screening Blood Tests, Endoscopic Ultrasound, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Major Depression
Testosterone and Major Depression
Context - As men age, testosterone levels decline leading to symptoms that overlap with the symptoms of major depression. Little is known about the potential role of testosterone in the treatment of major depression.Objective …
- Trial name
- NCT00286546
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Polycystic Ovary Syndrome
Relationship of the Chinese Medical Constitution & Syndromes in Patients With Polycystic Ovary Syndrome
This study is a cross-sectional study. The purpose is to understand the characteristics of Chinese medicine constitutional syndrome in patients with polycystic ovary.
- Trial name
- NCT04425083
- Testing
- no intervention
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
Fallopian Tube Cancer, Ovarian Cancer
Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer
The purpose of this study is to learn about possible changes in brain anatomy and function, and in thinking abilities, such as memory skills, in patients with ovarian cancer who receive treatment with chemotherapy.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01591772
- Testing
- Neuroimaging & Neuropsychological Evaluation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer
Thiol-disulfide Homeostasis in Patients With Ovarian Cancer
Ovarian cancer is the third most common after endometrial and cervical cancer in societies with a high standard of living; It is the second most common type of gynecological cancer after cervical cancer in societies with a low…
- Trial name
- NCT05011539
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Tepecik Training and Research Hospital
Papillary Thyroid Carcinoma
Microwave Ablation and Surgical Resection for Micropapillary Thyroid Carcinoma
The study aimed to compare the efficacy and safety of papillary thyroid microcarcinoma (PTMC) treated with microwave ablation(MWA) and surgery resection (SR), and to explore the tumor characteristics suitable for each treatment…
- Trial name
- NCT04197960
- Testing
- Microwave ablation, Surgical resection
- Where
- China
- Volunteers
- 973 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men
A Study to Learn How Safe Elinzanetant is, How it Affects the Body, and How it Moves Into, Through and Out of the Body After Single and Multiple Doses in Japanese Healthy Female Adults
Researchers are looking for a new way to treat women who have symptoms that are caused by the sex hormonal changes that happen when a woman's body is going through the menopause.
- Trial name
- NCT04981431
- Testing
- Elinzanetant (BAY3427080)
- Where
- Japan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bayer
Cancer, Endometrial Cancer
Estrogen, Diet, Genetics and Endometrial Cancer
The purpose of this study is to see how people's diets, other aspects of their lifestyles, and their individual genetic makeup affect their chances of getting endometrial cancer (cancer of the uterus).
- Conditions
- Cancer, Endometrial Cancer, Ovarian Cancer, Corpus Uteri
- Trial name
- NCT00587886
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 1,315 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes
A Study to Learn More About How the Study Treatment Elinzanetant (or BAY3427080) Moves Into, Through and Out of the Body, How Safe it is and How it Affects the Body After Taking Single and Multiple Doses in Healthy Women Aged 40 to 65 Years
Researchers are looking for a better way to treat men and women with vasomotor symptoms, a condition of having hot flashes caused by hormonal changes.
- Conditions
- Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes, Healthy Volunteers
- Trial name
- NCT05381142
- Testing
- Elinzanetant (BAY3427080)
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Alcohol Drinking, Sex Behavior
Alcohol and Implicit Process in Sexual Risk Behavior in MSM
The current study is the first empirical investigation that directly addresses the correspondence between responses regarding indicators of risky sexual behavior while under the influence of alcohol in the laboratory and the…
- Conditions
- Alcohol Drinking, Sex Behavior, Men
- Trial name
- NCT03361384
- Testing
- Alcohol
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Thyroid Gland Carcinoma
An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy
This trial investigates whether hyperpolarized magnetic resonance imaging (hpMRI) can predict treatment response in patients with thyroid cancer and other malignancies of the head and neck undergoing radiation therapy and/or…
- Trial name
- NCT04589624
- Testing
- Hyperpolarized Carbon C 13 Pyruvate, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Ovarian Cancer
Clinical Significance of Germline BRCA Mutations
The goal of this study is to help us learn more about the roles of genes in cancers that run in families. Sometimes, we are born with genes that are changed or altered. Gene changes are called mutations.
- Trial name
- NCT00579488
- Where
- 7 sites in United States
- Volunteers
- 13,320 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Polycystic Ovary Syndrome
Molecular Basis of PCOS in Oocytes and Surrounding Cells
Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age that is characterized by elevated androgen levels, ovulatory dysfunction and polycystic ovarian morphology (PCOM).
- Trial name
- NCT04493788
- Testing
- Blood test, ultrasound and egg retrieval
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
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