Clinical trials: Endocrine System Disorder
Polycystic Ovary Syndrome
Intestinal Microbiota Survey of Polycystic Ovary Syndrome
Polycystic Ovary Syndrome is kind of disease with unclear etiology. Recent studies on intestinal microbiota have raised the possibility that dysbiosis of intestinal microbiota maybe a novel theory for the development of…
- Trial name
- NCT02937090
- Testing
- Blood Draw, Stool collection
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
T2DM (Type 2 Diabetes Mellitus)
Safety, Tolerance and Pharmacokinetics of THR-1442 in Chinese Healthy Subjects
The purpose of this study was to investigate Safety, tolerability and pharmacokinetics in Chinese healthy subjects.
- Trial name
- NCT05369078
- Testing
- THR-1442 20mg Single dose, THR-1442 20mg Multiple dose group
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Newsoara Biopharma Co., Ltd.
Diabetes Mellitus
Using Networks, Informatics, Technology, and Education in Care for People With Diabetes
The costs of diabetes care (in health care dollars \& human suffering) in the United States are second only to mental illness. Randomized control trials \& observational studies have shown that glycemic control is predictive of…
- Trial name
- NCT00421850
- Testing
- UNITED Planned Care
- Where
- United States
- Volunteers
- 3,491 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hypogonadism, Precocious Puberty
Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle
OBJECTIVES: I. Evaluate the sleep-entrained patterns of gonadotropin-releasing hormone (GnRH) and sex steroid secretion in normal and hypogonadal children. II.
- Trial name
- NCT00004335
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Mellitus, Coronary Artery Disease,
Young Toe-Brachial Index Assessment
The Toe-Brachial Index (TBI) that has been using in our laboratory is 0.6, but the average value we measured in normal individuals is about 1.0, furthermore, we can not find out the reference of TBI that is currently being used.
- Conditions
- Diabetes Mellitus, Coronary Artery Disease,, Vascular Diseases
- Trial name
- TBI (NCT02020850)
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes Mellitus
Effect of Fenugreek on Blood Sugar and Insulin in Diabetic Humans
The purpose of this study is to determine if bread containing fenugreek reduces blood sugar and insulin compared to identical bread without fenugreek.
- Trial name
- Fenugreek (NCT00597350)
- Testing
- Trigonella foenum-graecum (fenugreek)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type2 Diabetes Mellitus, Cardiovascular Diseases
Mil Familias-Santa Barbara's Operational Pilot to Understand Diabetes in the Latino Community
The Mil Familias Program is a 10-year initiative to reduce the burden of cardio-metabolic disease among Latino families in the Central Coast of California.
- Trial name
- MilFamilias (NCT03736486)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Type 2 Diabetes
Characterization of the Variability of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Healthy Subjects
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01454973
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Foundation for the National Institutes of Health
Hyperglycaemia (Diabetic), Healthy Volunteers
The Assessment of Single-Dose Safety,Tolerability, Pharmacokinetics and Pharmacodynamic of Globalagliatin Hydrochloride
This is a phase 1 randomized,double-blind,placebo-controlled study with single oral dose of globalagliatin hydrochloride (SY-004) administered to chinese healthy subjects to evaluated the safety, tolerability, pharmacokinetics…
- Trial name
- NCT03171623
- Testing
- globalagliatin hydrochloride
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Yabao Pharmaceutical Group
Diabetes, HIV Infections
The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism
The purpose of this study is to determine the mechanisms by which HIV protease inhibitors contribute to the development of diabetes in HIV-infected patients.
- Conditions
- Diabetes, HIV Infections, Insulin Resistance
- Trial name
- NCT00259727
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Diabetes, Weight Loss
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)
The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking.
- Trial name
- NCT06861790
- Testing
- tVNS, Complete Vagotomy, Anterior Vagotomy
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 2 Diabetes
A Study to Demonstrate the Bioequivalence of Sitagliptin/Metformin Combination Tablets and Co-administration of Sitagliptin and Metformin as Individual Tablets (0431A-095)
A three part study to demonstrate the bioequivalence of a single dose of the Final Market Image (FMI) of sitagliptin/metformin 50/500, 50/850 and 50/1000 mg Fixed-Dose Combination (FDC) tablet and co-administration of…
- Trial name
- NCT00961480
- Testing
- sitagliptin phosphate (+) metformin hydrochloride, Comparator: metformin 500mg, Comparator: sitagliptin
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Vitamin D Deficiency, Pre-Eclampsia
Vitamin D in Pregnancy
Danish pregnant women are recommended ad daily vitamin D supplement of 10 µg. Despite the fact that 9 out of 10 women take vitamin D supplements, more than 40% of pregnant women are vitamin D deficient, putting them at an…
- Conditions
- Vitamin D Deficiency, Pre-Eclampsia, Fetal Growth Retardation, Gestational Diabetes
- Trial name
- GRAVITD (NCT04291313)
- Testing
- Vitamin D3 (90µg), Vitamin D3 (10µg)
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Periodontitis, Diabetes
Gingival Crevicular IL-34 and CSF-1 Levels in Patients With Periodontitis and Uncontrolled Type 2 Diabetes
Type 2 diabetes mellitus is a metabolic disorder. There is a bidirectional association between periodontal disease and DM. Currently there is no data relationship between CSF-1 and IL-34, periodontal disease and diabetes.The aim…
- Trial name
- NCT04891627
- Testing
- Gingival crevicular fluid
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uşak University
Endocrine Diseases
Endocrine Studies in Health and Disease
This study will evaluate healthy normal volunteers and patients with a variety of endocrine disorders to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) train physicians in…
- Trial name
- NCT00006073
- Where
- United States
- Volunteers
- 3,090 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Abdominal Obesity, Insulin Resistance
The Effect of Nordic Recommended Diet on the Features of Metabolic Syndrome - Multicentre Study
SYSDIET (Systems biology in controlled dietary interventions and cohort studies) is one of the three centres in the NCoE Food, Nutrition and Health, 2007-2011.
- Conditions
- Abdominal Obesity, Insulin Resistance, Impaired Glucose Tolerance, Type 2 Diabetes
- Trial name
- SYSDIET (NCT00992641)
- Testing
- Experimental diet, Control diet
- Where
- 8 sites in Denmark, Finland and 3 more
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Diabetes Mellitus, Diabetic Retinopathy
Serum GPER-1 and Oxidant/Antioxidant Levels on Retinopathy in Diabetic Patients
Observational, comparative, cross-sectional study
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Hormones
- Trial name
- NCT04930224
- Testing
- The effect of GPER-1 on the formation of diabetic retinopathy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Independent Living, Disability Free Survival
A Clinical Trial of STAtin Therapy for Reducing Events in the Elderly (STAREE)
The STAREE study will examine whether treatment with statin (atorvastatin 40mg) compared with placebo will prolong disability free survival and reduce major cardiovascular events amongst healthy elderly people (≥70 years).
- Conditions
- Independent Living, Disability Free Survival, Elderly, Healthy
- Trial name
- STAREE (NCT02099123)
- Testing
- Atorvastatin
- Where
- 6 sites in Australia
- Volunteers
- 9,971 people, healthy volunteers welcome
- Sponsor
- Monash University
Type 1 Diabetes
Closed-Loop Glucagon Administration For Hypoglycemia Treatment
This study will test the hypothesis that a wearable automated bionic pancreas system that automatically delivers glucagon only can prevent or treat hypoglycemia vs. usual care for people with type 1 diabetes > 21 years old.
- Trial name
- NCT02181127
- Testing
- Glucagon-only Bionic Pancreas
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
COVID-19 Pandemic, Endocrine System Diseases
Hormonal Contributors to COVID-19 Infection (COV-ENDO)
The goal of this observational study is to measure the changes in the parameters of endocrine function and tissue sensitivity to hormones induced by SARs-CoV-2 infection.
- Trial name
- COV-ENDO (NCT05749770)
- Testing
- blood testing
- Where
- Italy
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
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