Clinical trials: Endocrine System Disorder
Menopause
The BALANCE Study - Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women
The menopausal transition is associated with a decline in oestrogen levels, contributing to adverse metabolic changes including increased central adiposity, systemic inflammation, and insulin resistance.
- Trial name
- BALANCE (NCT07565675)
- Testing
- ió everyday (a prebiotic- enriched gut health drink containing inulin)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Anovulation, FHA
FHA: Characterization of Metabolic Status, Brain Circuitry, and Stress-Reactivity
Functional Hypothalamic Amenorrhea (FHA), the spontaneous cessation of the menstrual cycle for at least 6 months after menstrual cyclicity has been established, is a common and reversible form of anovulation not due to…
- Conditions
- Anovulation, FHA, Eumenorrhea, Polycystic Ovary Syndrome
- Trial name
- NCT00453219
- Testing
- Screening evaluation, Meal Response, Blood Collection
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Insulin Resistance, Chronic Heart Failure
The Role of Insulin Resistance in Patients With Heart Failure and Type 2 Diabetes
The purpose of this cross-sectional comparative 2x2 trial study is to compare the degree of insulin resistance, myocardial function and selected metabolic parameters and to explore the pathophysiological mechanisms by which…
- Trial name
- CARMET2 (NCT02559128)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Diabetes
Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RZ-629 in Healthy Subjects and T2D
The main purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) biomarkers in single ascending doses (SAD), food effect, and multiple doses studies of RZ-629 in healthy…
- Trial name
- NCT06829563
- Testing
- RZ-629, Fasted, Fed
- Where
- Australia
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Rezubio Pharmaceuticals Co., Ltd.
Healthy Volunteers, Hepatic Insufficiency
A Single Dose Study of LY2605541 in Participants With Liver Impairment
The primary purpose of this study is to help answer the following research questions: To evaluate how much of the study drug (LY2605541) is in the blood of participants with varying degrees of liver impairment compared to those…
- Conditions
- Healthy Volunteers, Hepatic Insufficiency, Diabetes Mellitus, Type 2
- Trial name
- NCT01751399
- Testing
- LY2605541
- Where
- 2 sites in Germany, Hungary
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Reproductive Age, PCOS (Polycystic Ovary Syndrome)
Functional Proteins in Polycystic Ovary Syndrome
The concentration of functional proteins: kisspeptin, ghrelin, zonulin will be measured and compared in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR), in women with PCOS without IR, and in women without…
- Trial name
- NCT06793098
- Testing
- Measurement of kisspeptin concentration, Measurement of ghrelin concentration, Measurement of zonulin concentration
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Pregnancy Related, Pregnancy Disease
Fetal Autonomic Nervous sysTem Evaluation
The autonomic nervous system (ANS) is involved in cardiovascular, metabolic and cognitive processes, so its study in the fetus can provide relevant functional diagnostic and prognostic information.
- Conditions
- Pregnancy Related, Pregnancy Disease, Pregnancy Complications, Pre-Eclampsia
- Trial name
- FANTE (NCT06330987)
- Testing
- electrocardiograph
- Where
- Italy
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Type 2 Diabetes Mellitus
XW014 in Healthy Subjects and Patients With Type 2 Diabetes Mellitus (T2DM)
This is a Phase 1, randomized, double-blind, placebo-controlled, first-in-human (FIH) study to evaluate the safety, tolerability, food effect (FE), pharmacokinetics (PK), and pharmacodynamics (PD) of orally administered XW014 in…
- Trial name
- NCT05579314
- Testing
- XW014
- Where
- 3 sites in United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Sciwind Biosciences USA Co., Ltd.
Diabete Mellitus, Peripheral (Sensorimotor) Diabetic Polyneuropathy
Neurophysiological, Autonomic, and Sonographic Assessment of Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy causes pain, sensory loss, and foot risk; multimodal assessment enables earlier diagnosis and improved patient management.
- Trial name
- NCT07306884
- Testing
- Nerve conduction study, Nerve ultrasound, Autonomic assessment
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 2 Diabetes Mellitus, Osteoporosis
Osteoprosis in Type 2 Diabetic Patients- a Cohort Study
Some possible humoural and cellular mechanism for diabetes related osteoporosis/fractures were proposed and summarzied as the following, (1)Diabetes mellitus increases osteoclast function but decreases osteoblast function…
- Trial name
- NCT01846533
- Where
- Taiwan
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Type2 Diabetes Mellitus
Fiber Mix and Glycemic Response
This study determines the acute effect of a dietary fiber mix on blood glucose levels. Participants will consume the fiber mix as a drink and we will monitor changes in blood glucose levels.
- Trial name
- NCT03334643
- Testing
- Fiber mix
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Preterm Birth, Gestational Diabetes Mellitus (GDM)
Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology Compared to Other Fertility Treatments and Naturally Conceived Women: It is a Retrospective Cohort Study Conducted Over a 5-year Period at a Fertility Center in a Lebanese Hospital
Background: The number of couples experiencing difficulties conceiving and seeking treatment for infertility has increased dramatically over time.
- Conditions
- Preterm Birth, Gestational Diabetes Mellitus (GDM), Gestational Hypertension
- Trial name
- non (NCT06836843)
- Testing
- Since this is an observational study rather than an interventional study, the exposure type refers to all potential factors influencing pregnancy both before and during pregnancy
- Where
- Lebanon
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Type 1 Diabetes
Pancreas Volume in Preclinical Type 1 Diabetes
Type 1 diabetes (T1D) is characterized by a progressive destruction of insulin producing beta cells, resulting in a lifelong dependence on exogenous insulin.
- Trial name
- NCT02234947
- Testing
- MRI, US, and blood samples
- Where
- United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Florida
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIDDM, Obesity
Effect of Metformin, a Drug Used to Treat Diabetes, vs Placebo
Metformin is a drug used to treat patients with diabetes. The aim of this study is to examine the effect of Metformin along with a low-calorie diet on obese and/or overweight adults with an increased waist measurement.
- Trial name
- NCT05949008
- Testing
- Metformin Extended Release (ER) Oral Tablet
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Ovarian Cancer
Evaluation of Prognostic Monitoring for Women Who Have Completed Standard Treatment for Ovarian Cancer
The relationship between immune inflammation-related protein complexes inblood and recurrence or metastasis of ovarian cancer will be studied
- Trial name
- NCT05410015
- Testing
- Normal clinical treatment without intervention
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Healthy, Gestational Diabetes Mellitus in Pregnancy
A Mobile Health-enabled Lifestyle Intervention Among Women With History of Gestational Diabetes(GDM)
This study aims to explore: (1) the relationship between lifestyle factors (eating, movement behaviour, sleep and stress) and glycaemic profile, and (2) the feasibility of delivering lifestyle intervention through the proposed…
- Conditions
- Healthy, Gestational Diabetes Mellitus in Pregnancy, Diabetes, Gestational
- Trial name
- Reverse-DM (NCT05512871)
- Testing
- Personalized mHealth intervention to promote short-term metabolic and mental health among women with a history of Gestational Diabetes Mellitus (GDM)
- Where
- Singapore
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Type 2 Diabetes Mellitus
Orthogonal Polarisation Study in Young, Elderly and Type 2 Diabetics
Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease.
- Trial name
- NCT01476384
- Testing
- Glucose
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Polycystic Ovary Syndrome, Infertility, Female
Comparison of Ovulation Induction Cycle Outcomes Between Early and Late Dose Increments for Low Dose Gonadotropin Step-up Protocol Among Infertile Women Diagnosed With Polycystic Ovary Syndrome: Prospective Randomised Trial
Low dose gonadotropin step-up ovulation induction treatment is the universally accepted and utilized teratment protocol for infertile women diagnosed with polycystic ovary syndrome (PCOS).
- Trial name
- NCT04528849
- Testing
- Gonadotropin dose increment timing
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Immunosuppression, Hyperlipidemias
Cholesterol and Fatty Acid Synthesis in Islet and Liver Transplant Patients and Effect of Dietary Intervention
The purpose is to investigate possible mechanisms of increased blood lipid levels following transplantation, and also to see if a comprehensive dietary intervention is effective in reducing blood lipid levels in post-transplant…
- Conditions
- Immunosuppression, Hyperlipidemias, Diabetes Mellitus, Type 1
- Trial name
- NCT00947635
- Testing
- Dietary intervention - supplements
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Alberta
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