Clinical trials: Endocrine System Disorder
Neoplasms, Solid Tumors
An Exploratory Study of Zanidatamab in HER2-positive Advanced Tumor After at Least One Line of Standard Therapy
The goal of this clinical trial is to learn if Zanidatamab can treat HER2-positive advanced tumors in adults. The main question it aims to answer is: What is the objective response rate of Zanidatamab in adult patients with HER-2…
- Conditions
- Neoplasms, Solid Tumors, HER2 Positive Solid Tumor, Endometrial Neoplasm
- Trial name
- NCT07631871
- Testing
- Zanidatamab
- Volunteers
- 10 people
- Sponsor
- Haihua Yuan
Advanced Cancer, Advanced Malignancies
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
The primary purpose of this study is to assess the safety and tolerability of AB598 in participants with advanced malignancies.
- Conditions
- Advanced Cancer, Advanced Malignancies, Bladder Cancer, Cervical Cancer
- Trial name
- ARC-25 (NCT05891171)
- Testing
- AB598, Zimberelimab, Fluorouracil
- Where
- 19 sites in United States, Australia and 1 more
- Volunteers
- 40 people
- Sponsor
- Arcus Biosciences, Inc.
Diabetes Mellitus, Type 2
Effects of a Small Protein and Lipid Preload on Glucose Tolerance in Subjects With Impaired Glucose Homeostasis
The purpose of this study is: to measure the size of the effect on glucose tolerance of a small mixed protein and lipid meal given as a pre-load in individuals with different glucose tolerance status to investigate the underlying…
- Trial name
- NCT02342834
- Testing
- Small mixed protein and lipid meal
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Diabetes Mellitus, Type 1
Islet Cell Transplants for Diabetes
The purpose of this study is to test the safety and efficacy of islet cell transplants for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT00303134
- Testing
- Islet Cell Transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Diabetic Kidney Disease
The Multi-Center Clinical Study of Tang Shen Prescription on Type 2 Diabetic Kidney Disease in Early Stage
This study is a randomized, double-blinded, placebo-controlled clinical trial on type 2 diabetic Kidney Disease in early stage ( microalbuminuria excretion rate = 20-200mg/min) to evaluate the therapeutic effect of tang shen…
- Trial name
- NCT03009864
- Testing
- Tangshen Prescription
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Pancreatic Carcinoma
Concurrent Chemoradiotherapy Combined With Immunotherapy in Patients With Potentially Resectable Pancreatic Cancer
The objective of this study is to evaluate the efficacy and safety of concurrent chemoradiotherapy combined with immunotherapy in patients with potentially resectable pancreatic cancer.
- Trial name
- NCT05634564
- Testing
- Tislelizumab, Gemcitabine, Nab paclitaxel
- Where
- China
- Volunteers
- 62 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Pancreatic Cancer
Protocol for High-Risk Assessment, Screening, and Early Detection of Pancreatic Cancer
The purpose of this study is to find out whether Endoscopic Ultrasound (EUS) can detect early stage pre-cancerous or cancerous changes in the pancreas in patients at high-risk for the development of pancreatic cancer.
- Trial name
- NCT01662609
- Testing
- Endoscopic Ultrasound (EUS)
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
Guadecitabine and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
The purpose of this study is to look at how patients respond to treatment with guadecitabine and pembrolizumab. The researchers will also be looking at the amount of time it takes for cancer to get worse when participants take…
- Conditions
- Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- NCT02901899
- Testing
- Guadecitabine, Laboratory Biomarker Analysis, Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Northwestern University
Type 1 Diabetes
Hybrid Closed-Loop Hotel Studies With Medtronic PID Controller
The primary objective of this study is to evaluate the safety and efficacy of the Medtronic hybrid closed-loop (HCL) system utilizing the proportional-integral-derivative algorithm with insulin feedback (PID-IFB) optimized to…
- Trial name
- NCT02280863
- Testing
- Medtronic Hybrid Closed-loop System - Android Platform, Medtronic Hybrid Closed-loop Integrated System
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus
Effect of Green Tea Extract on Arterial Stiffness in Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) has become the epidemic of the XXI century. This chronic disease is also highly prevalent and primarily associated with an increased cardiovascular mortality and morbidity due to micro and…
- Trial name
- NCT02627898
- Testing
- green tea extract
- Volunteers
- 24 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Diabetic Kidney Disease, Diabetes Mellitus, Type 2
Possible Ameliorating Effect of N- Acetylcysteine (NAC) on Type-II Diabetes Induced Nephropathy
The study is focused on the possible improving effect of N-acetylcysteine on nephropathy of type-2 diabetic patients. Study design: Prospective clinical based study.
- Conditions
- Diabetic Kidney Disease, Diabetes Mellitus, Type 2, Diabetic Nephropathies
- Trial name
- (NAC) (NCT04531163)
- Testing
- N Acetylcysteine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Ovarian Cancer, Breast Cancer
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
This is an open-label, phase 1, dose escalation and dose expansion study to determine safety and tolerability, and to determine the maximum tolerated dose and / or recommended phase 2 dose of LNCB74 in participants with advanced…
- Conditions
- Ovarian Cancer, Breast Cancer, Endometrial Cancer, Non-Small Cell Lung Cancer
- Trial name
- LNCB74-01 (NCT06774963)
- Testing
- LNCB74
- Where
- 17 sites in United States
- Volunteers
- 145 people
- Sponsor
- LigaChem Biosciences, Inc.
Pancreatic Cancer
Vorinostat Plus Radiation Therapy in Pancreatic Cancer
Primary Endpoint: To determine the maximum tolerated dose (MTD) of vorinostat + radiation therapy (RT) in patients with locally advanced pancreatic cancer (LAPC). Secondary Endpoints: 1.
- Trial name
- NCT00831493
- Testing
- Chemoradiation (Radiation Therapy), Vorinostat
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Diseases, Heart Diseases
Interest of the SPECT-CT Scan SUVspect in the New Generation of Gamma-cameras With Semiconductor
Since 2017, a revolution began in the departments of nuclear medicine, with the routine use of gamma-cameras with semiconductor.
- Conditions
- Thyroid Diseases, Heart Diseases, Bone Diseases, Brain Diseases
- Trial name
- GAMMA-CAM (NCT03414021)
- Testing
- SPECT-CT Scan
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Lille Catholic University
Ovarian Cancer
Engineered Immune Effectors Against Ovarian Cancer
This is a single-arm, open-label, phase I/II trial to evaluate the safety and efficacy of ovarian cancer specific cytotoxic lymphocytes (OC-CTLs) in women.
- Trial name
- NCT03362606
- Testing
- OC-CTLs
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Diabetes Mellitus, Type 1
To Examine the Lung When People With Diabetes Take an Inhaled Form of Insulin, Compared to Subcutaneous Insulin.
To examine the lung when people with diabetes take an inhaled form of insulin, compared to subcutaneous insulin.
- Trial name
- NCT00143104
- Testing
- Inhaled insulin
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Pfizer
Secondary Hyperparathyroidism, Hemodialysis
Paricalcitol Compared to Maxacalcitol in Chronic Kidney Disease Patients With Secondary Hyperparathyroidism
This study is a exploratory comparison of the efficacy and safety of paricalcitol injection with maxacalcitol injection in chronic kidney disease participants receiving hemodialysis with secondary hyperparathyroidism.
- Trial name
- NCT00990704
- Testing
- paricalcitol, maxacalcitol
- Where
- 14 sites in Japan
- Volunteers
- 47 people
- Sponsor
- Abbott
Stage IV Pancreatic Cancer
Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer
The Investigators in the PCRT team have developed a therapeutic regimen which attacks both the tumor compartment and the stromal compartment of pancreatic cancer and induces complete responses in a small percentage of patients…
- Trial name
- NCT01488552
- Testing
- Gemcitabine, nab-paclitaxel, FOLFIRINOX
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pancreatic Cancer Research Team
Diabetes
EFFECTIVENESS OF A TRIPLE NUTRITIONAL INTERVENTION AND PHYSICAL IN PREDIABETIC PATIENRS
Diabetes represents a substantial burden on health care systems. People with prediabetes IGT (impaired glucose tolerance) or IFG (impaired fasting glucose) are at high risk of developing diabetes, and up to 50% progress to…
- Trial name
- NCT06820775
- Testing
- A TRIPLE INTERVENTION NUTRITION AND PHYSICAL ACTIVITY
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- Bioaraba Health Research Institute
Diabetes Complications, Cardiovascular Diseases
Diabetes Complications and the Risk of Cardiovascular and Cerebrovascular Diseases
This study is intended to include 3000 diabetic patients in our hospital to collect complete medical history data, comprehensively improve the screening of diabetic complications and cardiovascular and cerebrovascular risk…
- Conditions
- Diabetes Complications, Cardiovascular Diseases, Cerebrovascular Disease
- Trial name
- NCT04983277
- Testing
- no intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
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