Clinical trials: Endocrine System Disorder
Pancreatic Cancer
Biomarkers in Plasma Specimens From Patients Treated on Study CALGB-80303
RATIONALE: Studying plasma samples from patients with pancreatic cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
- Trial name
- NCT01664169
- Testing
- laboratory biomarker analysis
- Volunteers
- 307 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Alcohol Dependence, Depression
The MEADOW PROJECT (Mending the Effects of Alcohol and Depression on Women) and The Bridge Program (Connecting Recovery Treatment and Behavioral Health)
The aim of this study is to evaluate an interpersonally-focused intervention (Interpersonal Psychotherapy) for women with co-occurring alcohol dependence and depression.
- Trial name
- MEADOW/Bridge (NCT00851669)
- Testing
- Interpersonal Psychotherapy for Co-occurring Alcohol Dependence and Major Depression (IPT-ADMD), Treatment as Usual
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- University of Rochester
Pancreatic Cancer, Pancreatic Adenocarcinoma
MK-0646 and Gemcitabine +/- Erlotinib for Patients With Advanced Pancreatic Cancer
Objectives: Primary Objectives: Phase I: Determine the maximal tolerated dose (MTD) of MK-0646 in combination with gemcitabine or gemcitabine plus erlotinib and recommended phase II dose.
- Trial name
- NCT00769483
- Testing
- MK-0646, Gemcitabine, Erlotinib
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer, Pancreatic Adenocarcinoma
EUS BD vs ERCP TP for Pancreatic Cancer
This Endoscopic Ultrasound guided Biliary Drainage (EUS-BD) vs. Endoscopic Retrograde Cholangiopancreatography (ERCP-TP) trial (BILPAL) is a randomized controlled multicenter trial that will provide evidence whether or not…
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Biliary Tract Neoplasms, Biliary Duct Obstruction
- Trial name
- BILPAL (NCT03063554)
- Testing
- Endoscopic Ultrasound Guided Biliary Drainage, ERCP
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Weill Medical College of Cornell University
T1DM - Type 1 Diabetes Mellitus
Allogeneic Anti-CD7 CAR-T for Type 1 Diabetes
Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by autoimmune destruction of pancreatic beta cells, leading to absolute insulin deficiency and lifelong dependence on exogenous insulin.
- Trial name
- NCT07528105
- Testing
- Allogeneic CD7-Targeted CAR-T Cell Injection
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Type 1, Hyperlipidemias
Efficacy of Colesevelam in Subjects With Type 1 Diabetes Mellitus
This is a prospective, randomized, double blind, parallel, placebo controlled clinical trial evaluating the efficacy of colesevelam HCl in reducing LDL in subjects with type 1 diabetes mellitus over a 12 week treatment period.
- Trial name
- NCT00938405
- Testing
- Colesevelam HCl
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Thyroid, PD-1
Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors
The purpose of this research study is to see if the amount of vitamin D in ones blood makes it more or less likely to develop thyroid gland toxicity when being treated with immunotherapy that blocks the activity of proteins…
- Conditions
- Thyroid, PD-1, Cancer
- Trial name
- NCT04615988
- Testing
- blood draw and questionnaire completion, questionnaire completion, blood collection
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Graves Ophthalmopathy
A Safety and Tolerability Study of Otelixizumab in Thyroid Eye Disease
The purpose of this study is to investigate the safety and tolerability of otelixizumab in patients with Graves' ophthalmopathy (thyroid eye disease).
- Trial name
- NCT01114503
- Testing
- Otelixizumab - low dose, Otelixizumab - medium low dose, Otelixizumab - medium high dose
- Where
- United Kingdom
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Pancreatic Neoplasms, Pancreatic Cancer
Immune Checkpoint Inhibition (Tremelimumab and/or MEDI4736) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer
Background: Stereotactic body radiation therapy (SBRT) is used to treat cancer. It is a way of giving very focused beams of radiation to tumors.
- Conditions
- Pancreatic Neoplasms, Pancreatic Cancer, Cancer of Pancreas, Cancer of the Pancreas
- Trial name
- NCT02311361
- Testing
- Durvalumab, Tremelimumab, Sterostatic body radiation therapy (SBRT)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Type 2 Diabetes Mellitus
Study to Evaluate the Efficacy and Safety of KBP-042 in Patients With Type 2 Diabetes
This is a multicentre, randomized, double-blind, placebo-controlled, parallel-group Phase II trial of twelve weeks of KBP-042 administered as daily s.c.
- Trial name
- NCT03230786
- Where
- 30 sites in Czechia, Denmark and 4 more
- Volunteers
- 255 people
- Sponsor
- KeyBioscience AG
Diabetes Mellitus Type 2
Effect of Moringa Leaf Capsules on Glycemic Control of Type 2 Diabetic Patients
A randomized clinical trial will be done on 50 patients , randomly divided into two groups by lottery method to compare the glycemic control in patients of Type 2 Diabetes Mellitus by the use of Moringa Oleifera (MO) capsules.
- Trial name
- NCT06125873
- Testing
- Metformin
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Islamabad Medical and Dental College
Diabetes Type 2
The Effect of Aliskiren on Endothelial Function in Pre-Diabetes and Diabetes
The purpose of this research is to study and determine the effects of Aliskiren on blood vessels and blood flow. The primary hypothesis is that Aliskiren will increase endothelial function by 30% or more in comparison to the…
- Trial name
- NCT01165983
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cryptorchidism
Transection Versus Ligation of Internal Spermatic Vessels in Laparoscopic Fowler-Stephens Orchidopexy
This is a comparative study to see the outcome of yransection versus ligation of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis in assisting the descent of the testis…
- Trial name
- NCT06558994
- Testing
- Transection of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis, Ligation of internal spermatic vessels in first stage laparoscopic Fowler-Stephens orchidopexy for intra-abdominal testis
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Testicular Cancer
Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy
Germ cell tumors, a relatively rare disease, but most common malignancy in young males, occur most frequently in testis. The incidence is about 1%, but is increasing in the majority of developed countries.
- Trial name
- GCT (NCT00772694)
- Testing
- sorafenib
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Fondation Wygrajmy Zdrowie
Type 2 Diabetes Mellitus (T2DM)
Mindfulness Training in Type 2 Diabetes
This study aims to evaluate the effects of mindfulness-based self-management education on diabetes-related difficulties and empowerment in individuals with type 2 diabetes.
- Trial name
- MindfulT2DCA (NCT07617766)
- Testing
- Mindfulness-Based Self-Management Education, Usual Care
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ataturk University
Ovarian Cancer, Peritoneal Cancer
Chemotherapy vs Hormonal Treatment in Platinum-resistant Ovarian Cancer Resistant or Refractory to Platinum and Taxane
A randomized study of chemotherapy versus hormonal treatment in patients with ovarian cancer resistant or refractory to platinum and taxane.
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Cancer of the Fallopian Tube
- Trial name
- NCT02728622
- Testing
- Tamoxifen, Chemotherapy
- Volunteers
- 241 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
Depression, Diabetes
A Helping Hand Among Low-Income Patients
Study Hypotheses (Ho) and Research Questions (RQ): Ho1. AHH will significantly improve patient depression treatment acceptance/adherence and depression symptoms vs UC at 6 and 12 months post-baseline. Ho2.
- Conditions
- Depression, Diabetes, Heart Disease
- Trial name
- AHH (NCT02147522)
- Testing
- Self-care management
- Where
- 3 sites in United States
- Volunteers
- 348 people
- Sponsor
- University of Southern California
Turner Syndrome
Turner Syndrome Prenatal Diagnosis Study
The goal of this study is to compare the features of Turner syndrome in girls who are diagnosed before birth because of fetal concerns versus those who are diagnosed when their mother has an amniocentesis for another reason.
- Trial name
- NCT01668251
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Children's Hospital
Diabetes Mellitus
Vascular Markers During OGTT in Diabetics and First-degree Relatives
Arterial stiffness is associated with increased risk for cardiovascular disease. Moreover, the integrity of endothelial glycocalyx plays a vital role in vascular permeability, inflammation and elasticity.
- Trial name
- NCT02244736
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Athens
Diabetes Mellitus, Lipohypertrophy
Glucose Variability in Subclinical Hypertrophy
Evaluation of insulin absorption at sites affected by clinically apparent lipohypertrophy through short-term continuous glucose monitoring has shown inconsistent results and it is yet unknown how or if subclinical lipohypertrophy…
- Trial name
- NCT02748434
- Testing
- Lipohypertrophy, Normal Subcutaneous Tissue
- Where
- 2 sites in Canada
- Volunteers
- 9 people
- Sponsor
- University of British Columbia
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