Clinical trials: Endocrine System Disorder
Secondary Hypogonadism
Evaluation of Pharmacokinetic and Safety Profile of Androxal in Male Subjects With Impaired Renal Function
To determine and compare the pharmacokinetics (PK) of a single dose of 25 mg Androxal in overweight male subjects with various stages of renal impairment and in volunteers with normal renal function.
- Trial name
- NCT01923857
- Testing
- Androxal 25 mg
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Type 2 Diabetes Mellitus, Hypertension (Without Type 2 Diabetes Mellitus)
Empowering Primary Care Providers and Patients to Improve Chronic Disease Outcomes: The EMPOWER Participatory Action Research (EMPOWER - PAR)
BACKGROUND Chronic disease management (CDM) presents enormous challenges to the primary care workforce due to the rising epidemic of cardiovascular risk factors.
- Trial name
- NCT01545401
- Testing
- EMPOWER-PAR Intervention
- Where
- Malaysia
- Volunteers
- 1,545 people
- Sponsor
- Ministry of Health, Malaysia
Type II Diabetes
A Study to Assess the Effect of Food on HR20033 and Pharmacokinetic After Multiple Dose in Healthy Volunteers
According to the objective, the trial is constituted by two study groups: one is food effect assessment group, and another is multiple dose pharmacokinetic assessment group.
- Trial name
- NCT05120219
- Testing
- FDC tablet
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Pancreatic Cancer
Adebrelimab Combined With Irinotecan Liposomal (II), Oxaliplatin, and 5-FU/LV Conversion Therapy for Locally Advanced Pancreatic Cancer
This trial is a prospective, single-arm, single-center, phase II clinical study, mainly targeting subjects with locally advanced pancreatic cancer, to explore the efficacy and safety of adebrelimab combined with irinotecan…
- Trial name
- NCT06766019
- Testing
- Adebrelimab combined with irinotecan liposomal (II), oxaliplatin, and 5-FU/LV
- Where
- China
- Volunteers
- 47 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pancreatic Cancer
BMS-247550 in Treating Patients With Advanced Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of BMS-247550 in treating patients who have advanced…
- Trial name
- NCT00016965
- Testing
- ixabepilone
- Where
- 95 sites in United States
- Sponsor
- SWOG Cancer Research Network
Diabetes
Glycemic Response to Six Meal Replacements in Persons With Type 2 Diabetes Mellitus
This will be a randomized, cross-over design. Subjects will be randomized to one of six interventions on six separate study days, 1 week apart.
- Trial name
- NCT03155867
- Testing
- Meal replacement
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Société des Produits Nestlé (SPN)
Diabetes Mellitus, Type 2, Home Visit
Home-Based Intervention to the Diabetics
Why is the research needed? This study reflects the complexity of the process that patients with diabetes are experiencing when staying at home away from the supervision of health professionals.
- Trial name
- NCT04104711
- Testing
- Home visits, health education
- Volunteers
- 81 people
- Sponsor
- Dilay AÇIL,PhD
Hypogonadism
Testosterone Replacement in Renal Failure
The purpose of this trial is to evaluate the effect of testosterone replacement in men with renal failure (on dialysis) who also have low testosterone.
- Trial name
- NCT02712944
- Testing
- Testosterone, Saline
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Texas Tech University Health Sciences Center
Polycystic Ovary Syndrome, Insulin Resistance
Serum Biomarker Levels Improvement in Poly Cystic Ovarian Syndrome: Impact of Metformin Compared to Healthy Controls
The goal of this interventional study is to assess the effect of drug metformin in improving the fertility hormones and reducing the inflammatory hormones in polycystic ovarian syndrome (PCOS) patients.
- Trial name
- NCT06479434
- Testing
- Metformin
- Where
- Pakistan
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Cancer, Tumor, Solid
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced…
- Conditions
- Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
- Trial name
- NCT05620134
- Testing
- JK08, Pembrolizumab, Lenvatinib Pill
- Where
- 11 sites in Belgium, Spain
- Volunteers
- 263 people
- Sponsor
- Salubris Biotherapeutics Inc
Insulin Dependent Diabetes Mellitus 1
Longevity of Multi-Slitted Catheter With Lantern Technology
To determine time to set failure when the Convatec Inset II with Lantern technology (Convatec Lantern) infusion set with multi-slitted catheter is worn for up to 10 days
- Trial name
- Lantern (NCT03819634)
- Testing
- Inset II with Lantern Technology
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Stanford University
Metabolic Syndrome
Effect of a High-Protein Diet and/or High-Intensity Training on Metabolic Syndrome
The objective of this study is to determine the combined effects of a high-protein diet and high-intensity training on metabolic syndrome risk factors in women aged 30-65.
- Trial name
- EPHIT (NCT01622634)
- Testing
- Sprint Interval Exercise, Higher PRO Diet, Higher CARB Diet
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Ovarian Cancer
Genomic Directed Salvage Chemotherapy With Either Liposomal Doxorubicin Or Topotecan
This pilot study will help us to determine the success of using a special technique called microarray technology to examine cancer genes in order to predict how individual women will respond to one of two therapies, liposomal…
- Trial name
- NCT00720096
- Testing
- Liposomal Doxorubicin, Topotecan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Insulin Resistance, Prediabetic State
Impact of Digital Therapeutic on Metabolic Parameters
The purpose of this prospective randomized controlled study is to evaluate the impact of a six-month digitally administered behavioral change program on body weight, glycemic control and other metabolic parameters in obese adults…
- Conditions
- Insulin Resistance, Prediabetic State, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT04573296
- Testing
- Vitadio, Conventional high-intensity lifestyle intervention program
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Vitadio s.r.o.
Pancreatic Cancer
BYL719 in Combination With Gemcitabine and (Nab)-Paclitaxel in Locally Advanced and Metastatic Pancreatic Cancer
The main purpose of this study is to see primarily if BYL719 is safe to be given to patients in combination with gemcitabine and nab-paclitaxel.
- Trial name
- NCT02155088
- Testing
- BYL719, Gemcitabine, (nab)-paclitaxel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Type 1 Diabetes
Kids Diabetes Telemedicine Study (KITES)
Randomised prospective single-center clinical trial evaluating the outcomes of children with type 1 diabetes followed up by remote telemedicine check-ups without their personal present at the outpatient clinic.
- Trial name
- KITES (NCT05484427)
- Testing
- Telemedicine
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital, Motol
Diabetes (DM), Diabetes (Insulin-requiring, Type 1 or Type 2)
MiniMed Fit Payload Wear Pediatric Study
The purpose of this study is to assess MiniMed Fit Payload adhesive components in different wear locations over a 7-day period to support development of the future commercialized patch pump in participants 7-17 years of age.
- Conditions
- Diabetes (DM), Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes in Children, Diabetes in Adolescence
- Trial name
- NCT07675161
- Testing
- MiniMed Fit Payload adhesive components
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Medtronic MiniMed, Inc.
Pancreatic Adenocarcinoma Resectable, Pancreatic Adenocarcinoma Locally Advanced
Effect on Tumor Perfusion of a Chemotherapy Combining Gemcitabine and Nab-paclitaxel (Abraxane) in Pancreatic Cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with conventional treatments having little impact on disease course.
- Conditions
- Pancreatic Adenocarcinoma Resectable, Pancreatic Adenocarcinoma Locally Advanced, Pancreatic Adenocarcinoma Metastatic
- Trial name
- NEOPAX-001 (NCT01715142)
- Testing
- Gemcitabine, Abraxane
- Where
- 2 sites in Belgium
- Volunteers
- 23 people
- Sponsor
- Jean-Luc Van Laethem
Polycystic Ovarian Syndrome (PCOS), Infertility
Theta Healing-Based Intervention in Women With Polycystic Ovary Syndrome
This randomized controlled study aims to evaluate the effect of a Theta Healing-based intervention on fertility concerns, self-compassion, and body image in women diagnosed with Polycystic Ovary Syndrome (PCOS).
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Infertility, Psychological Stress
- Trial name
- NCT07630441
- Testing
- Theta Healing-Based Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ankara Medipol University
Dialysis, Chronic Kidney Disease
Next Generation Advanced Insulin Delivery System in Adults With Diabetes and Advanced Renal Disease
The goal of this this randomized, clinical trial is to test an automated insulin delivery system (AID) in people with type 1 or type 2 diabetes who are on hemodialysis, peritoneal dialysis, or have advanced chronic kidney disease…
- Conditions
- Dialysis, Chronic Kidney Disease, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT06330194
- Testing
- 2nd Generation Automated Insulin Delivery (AID) system
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steno Diabetes Center Copenhagen
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