Clinical trials: Endocrine Therapy Adverse Reaction
ER+ Breast Cancer, HER2-negative Breast Cancer
Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer
This study is a pragmatic international, multicenter, randomized, open label 3- arm trial of standard care vs. two pharmacological interventions: duloxetine or furosemide in patients with stage I-III ER+/HER2- early breast cancer…
- Conditions
- ER+ Breast Cancer, HER2-negative Breast Cancer, Breast Cancer Stage I, Breast Cancer Stage II
- Trial name
- NCT06407401
- Testing
- Duloxetine 60 MG, Furosemide 40 mg, Booklet for healthy behaviors
- Volunteers
- 399 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pancreatic Neoplasms, Pancreatic Cancer
Baduanjin for Quality of Life in Pancreatic Cancer Chemotherapy
Baduanjin is a traditional Chinese mind-body exercise originating from the Song Dynasty, integrating body adjustment, breathing regulation, and mental focus.
- Conditions
- Pancreatic Neoplasms, Pancreatic Cancer, Drug-Related Side Effects and Adverse Reactions (MeSH Term)
- Trial name
- BDJ-PC (NCT07791550)
- Testing
- Baduanjin Exercise
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer, Endocrine Therapy
Relationship Between Body Composition, Food Consumption, and Micro and Macronutrients With Gene Expression in Breast Cancer
The protocol involves measurement of 25 hidroxy vitamin D, gene expression of cytochrome and vitamin D receptor , endoxifen, tamoxifen, exemestane, and other metobolites related to nutrition and endocrine metabolism.
- Conditions
- Breast Cancer, Endocrine Therapy, Endocrine Therapy Adverse Reaction, Vitamin D Deficiency
- Trial name
- NUTRIBREAST (NCT04389424)
- Testing
- Tamoxifen, Exemestane, Anastrozole
- Where
- Mexico
- Volunteers
- 300 people
- Sponsor
- Instituto Jalisciense de Cancerologia
Metabolic Disturbance, Hyperprolactinemia
Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment
The goal of this clinical trial is to explore the potential of metformin in managing olanzapine-induced metabolic disturbance and hyperprolactinemia in patients with schizophrenia. The main questions it aims to answer are: 1.
- Conditions
- Metabolic Disturbance, Hyperprolactinemia, Schizophrenia
- Trial name
- NCT06326840
- Testing
- Metformin
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Taipei Medical University Hospital
Breast Cancer
Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer
Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog.
- Trial name
- NCT00260975
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Breast Cancer, Aromatase Inhibitors
Prevalence and Risk Factors for Pain and Related Adverse Reactions Among Breast Cancer Survivors on Aromatase Inhibitors
We obtained the occurrence of pain sensation, pain mood, sleep, etc. during endocrine therapy in breast cancer patients through telephone follow-up, and analyzed risk factors through artificial intelligence
- Conditions
- Breast Cancer, Aromatase Inhibitors, Endocrine Therapy, Pain
- Trial name
- NCT05628077
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Peking University People's Hospital
Ovarian Cancer, Cognitive Impairment
Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT
This is a phase I, dose-escalation and phase II dose-expansion clinical trial determining the maximum tolerated dose (MTD) and safety and tolerability of adding N-Acetyl-Cysteine (NAC) to ovarian cancer patients who are receiving…
- Trial name
- NCT04520139
- Testing
- N-Acetyl-Cysteine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Irvine
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Hypothyroidism, Exophthalmos
The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions
Iodine 131 (131I） treatment on Graves disease and Graves ophthalmopathy relationship has always been the focus of debate. Majority view is that the current treatment does not increase 131I Graves ophthalmopathy, therefore,Graves…
- Trial name
- NCT01204359
- Testing
- Iodine 131
- Where
- 2 sites in China
- Volunteers
- 627 people
- Sponsor
- Sun Yat-sen University
Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus
Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men
The aim of the study was to assess the effect of high intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetes males.It is a prospective study, conducted between march 2021 and July…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus, Statin Adverse Reaction, Hypogonadism, Male
- Trial name
- NCT05806723
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Hopital La Rabta
Ovarian Neoplasm
DOXIL for Consolidation Therapy in Ovarian Cancer.
The primary objective for this study is to evaluate the development, frequency and severity of hand foot syndrome (HFS) in ovarian cancer subjects treated with Doxil®, as consolidation therapy, on an every two week schedule.
- Trial name
- NCT00248248
- Testing
- liposomal doxorubicin
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Southeastern Gynecologic Oncology
Cardiovascular Diseases, Cardiotoxicity
Cancer Treatment Related Cardiovascular Toxicity: Comprehensive Myocardial and Vascular Phenotyping
Observational prospective cohort study designed to assess the mechanisms of fluoropyrimidine induced cardiovascular toxicity.
- Conditions
- Cardiovascular Diseases, Cardiotoxicity, Fluorouracil Adverse Reaction, Malignancy
- Trial name
- PC-TOX (NCT06048458)
- Testing
- Cardiovascular magnetic resonance with stress perfusion, CT coronary angiography, Retinal OCT angiography
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Schizophrenia, Diabetes
Medication Reviews in Severe Mental Illness
This study aims to investigate the potential beneficial effects of a medication review by a clinical pharmacologist on patients with coexisting severe mental illness and diabetes.
- Conditions
- Schizophrenia, Diabetes, Metabolic Syndrome, Severe Mental Disorder
- Trial name
- NCT05243160
- Testing
- medication review
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Ovarian Cancer
A Chinese Patent Medicine Yangzhengxiaoji Capsule to Improve the Nausea of Niraparib in the Maintenance Treatment in Ovarian Cancer
This study is an open-label, single-Arm， phase II clinical trial of a Chinese Patent Medicine Yangzheng Xiaoji Capsule to improve the adverse reaction nausea of Niraparib in the first-line maintenance treatment in advanced…
- Trial name
- NCT05641506
- Testing
- Yangzheng Xiaoji, Niraparib
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Type 2 Diabetes, Herbal Medicine Adverse Reaction
Safety and Efficacy of Herbal Tea in Type 2 Diabetics
Nearly 25% of the world's population relies on traditional medicinal systems but for professionals their effectiveness and even more safety are the main concern.
- Trial name
- DIABHerbMix (NCT04054284)
- Testing
- Antidiabetic Herbal Tea, Herbal Tea
- Where
- 3 sites in Croatia
- Volunteers
- 60 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Diabetes Mellitus Type 2
ACEIs and ARBs Treatment in Diabetic Patients -Drug Interactions and Adverse Drug Effects
Proteinuria is an expression of diabetic nephropaty in type 1 and type 2 patients. Hypertenshion treatment and decreasing urine protein excretion, slow down renal deterioration.
- Trial name
- NCT00437775
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Assaf-Harofeh Medical Center
Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders
Sex, Psychopharmacology, and Diabetes
The term sexual (SD) dysfunction covers conditions that prevent people from having a satisfactory sex life. SD is a frequent and sometimes debilitating complication of mental illness and a known adverse reaction to…
- Conditions
- Schizophrenia, Schizophrenia Spectrum and Other Psychotic Disorders, Diabetes Mellitus, PreDiabetes
- Trial name
- SECRET (NCT05951660)
- Testing
- Educational intervention
- Where
- Denmark
- Volunteers
- 256 people
- Sponsor
- Zealand University Hospital
Testicular Neoplasms
The Platinum Study Comparison Group
The patients enrolled on this new study will serve as an appropriate comparison group consisting of patients with the diagnosis of germ cell testicular cancer who were cured with surgical resection and did not receive…
- Trial name
- NCT02890030
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Lawrence Einhorn
Type 2 Diabetes Mellitus
Examination of Dermatologic Effects From Subcutaneous Injections of ISIS 113715
10 healthy volunteers will be enrolled to each receive two subcutaneous injections of ISIS 113715 in the abdomen on Study Day 1. Each subject will receive their two injections within a 5-minute period.
- Trial name
- NCT00365781
- Testing
- ISIS 113715
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Vasopressin Causing Adverse Effects in Therapeutic Use, Shock
Registry of Patients in Shock Treated With Vasopressin
Arginine-vasopressin (AVP) is a non-catecholaminergic hormone produced in the hypothalamus and released into the circulation via the neurohypophysis.
- Conditions
- Vasopressin Causing Adverse Effects in Therapeutic Use, Shock, Vasopressor Adverse Reaction, Vasopressin Deficiency
- Trial name
- NCT06422975
- Testing
- Vasopressin
- Where
- 24 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Hospital Universitario 12 de Octubre