Clinical trials: Endocrine and Metabolic Diseases
Gestational Diabetes
Impact of Blood Glucose at the First Trimester of Pregnant Women With Gestational Diabetes on Maternal and Fetal Outcomes and Metabolic Disorders: a Multi-central Prospective Cohort Study
The study is to investigate the impact of blood glucose management at the first trimester of pregnant women with gestational diabetes on the maternal and fetal outcomes and metabolic disorder.
- Trial name
- NCT01833559
- Testing
- Dietary control, Insulin
- Where
- China
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Chronic Kidney Disease, Type 2 Diabetes Mellitus
An Observational Study Called FIRST-2.0 to Learn More About the Use of the Study Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
This is an observational study, in which data from people in the United States (US) with chronic kidney disease (CKD) together with type 2 diabetes (T2D) are studied.
- Trial name
- FIRST-2 (NCT05703880)
- Testing
- Finerenone (Kerendia, BAY948862)
- Where
- 2 sites in United States
- Volunteers
- 15,948 people
- Sponsor
- Bayer
Diabetes, Nocturnal Hypoglycemia
Adjusting Insulin Delivery to Activity
Increased daytime activity in children and adolescents with type I diabetes is known to be associated with overnight hypoglycemia.
- Trial name
- AIDA (NCT02299479)
- Testing
- Dexcom G4 Platinum CGM, Activity monitor
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Pancreatitis, Pancreatic Neoplasms
Follow-up Study of Complications of Acute Pancreatitis
This is a follow-up study focusing on long-term complications of acute pancreatitis. The primary purposes include: 1. To assess the incidence of type 2 diabetes mellitus（2-DM）,impaired glucose tolerance, metabolic abnormalities…
- Conditions
- Pancreatitis, Pancreatic Neoplasms, Metabolic Diseases, Hypertension, Portal
- Trial name
- FSCAP (NCT02305914)
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Heart Failure, Diabetes
Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes
A pragmatic electronic health record (EHR) based randomized controlled trial to evaluate the utility of providing Ultromics EchoGo analysis results and recommendations for HF risk prevention therapies using an EHR embedded…
- Trial name
- NCT06593314
- Testing
- Message with EchoGo, Standard Message
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes
Closed-loop Control of Glucose Levels (Artificial Pancreas) for 5 Days in Adults With Type 1 Diabetes
Closed-loop strategy is composed of three components: glucose sensor to read glucose levels, insulin pump to infuse insulin and a dosing mathematical algorithm to decide on the required insulin dosages based on the sensor's…
- Trial name
- NCT02488616
- Testing
- 5-day intervention with single-hormone closed-loop strategy, 5-day intervention with sensor-augmented pump therapy, Insulin pump
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Type 1 Diabetes Mellitus
MSC Administration for the Management of Type 1 Diabetic Patients
The purpose of this study is to evaluate whether the administration of multipotent stromal cell also referred as to mesenchymal stem cells (MSCs), modified Type 1 Diabetes progression.
- Trial name
- DMT1-MSC (NCT02893306)
- Testing
- MSCs
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Universidad del Desarrollo
Diabetes Mellitus, Type 1, NASH
Effect of Dipeptidyl Peptidase- 4 Inhibitors on Non-Alcoholic Steatohepatitis and Type 1 Diabetes
Background: Non-alcoholic steatohepatitis (NASH) is an advanced form of non-alcoholic fatty liver disease (NAFLD) that can precipitate to advanced fibrosis and leads to cardiovascular morbidity and mortality.
- Trial name
- NCT06348706
- Testing
- Dipeptidyl peptidase 4 (DPP-4) inhibitor
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Type 2 Diabetes
A Phase 3 Study to Evaluate Efficacy and Safety of HDM1002 Tablets in Adults With Type 2 Diabetes Mellitus
This is a multicenter, randomized, double-blind, active-controlled, parallel-group study, which aims to provide data on the efficacy and safety of HDM1002 tablets compared with dapagliflozin in adults with type 2 diabetes…
- Trial name
- NCT07082114
- Testing
- HDM1002 100 mg, HDM1002 200 mg, HDM1002 400 mg
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Type 2 Diabetes, Non Alcholic Fatty Liver Disease
Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions ranging from liver steatosis (NAFL), steatohepatitis (NASH), advanced liver fibrosis and ultimately leads to cirrhosis in a significant proportion of…
- Trial name
- B-LIFT (NCT06035874)
- Testing
- Bempedoic acid
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Medanta, The Medicity, India
Type 2 Diabetes Mellitus
A 2 Year Trial of Patients With Type 2 Diabetes Focusing on Cardiovascular Diagnostics and Metabolic Control
The purposes of this study are: to investigate the extent of cardiovascular complications in a representative cohort (n=135) of adult patients with type 2 diabetes; to examine if modern non-invasive assessment can replace…
- Trial name
- NCT00133718
- Testing
- Combined lifestyle intervention and optimisation of pharmacological treatment
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Asker & Baerum Hospital
Diabetes Mellitus, Type 2
Short Message Service for Type 2 Diabetes
Diabetes is a chronic disease where type 1 diabetes (T1D) is due to autoimmune ẞ-cell destruction, usually leading to absolute insulin deficiency, type 2 diabetes (T2D) is due to a progressive loss of ẞ-cell insulin secretion…
- Trial name
- SMS4T2D (NCT04236206)
- Testing
- Mobile Phone Short Message Service
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Patients With Type 1 Diabetes
Allogeneic Islet Transplantation for the Treatment of Type 1 Diabetes
It is a multicentre, sequential, phase II clinical trial, aiming at evaluating the allogeneic islet transplantation for the treatment of type 1 diabetes.
- Trial name
- GRIIF (NCT01974674)
- Testing
- Allogeneic transplantation of intrahepatic islet
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Disease, Diabete Mellitus
Detection of Diabetic Foot Skin Damage Using Plantar Mechanical Parameters
Diabetes represents one of the major chronic diseases, with diabetic ulcers being a significant adverse prognosis. Approximately 80% of lower limb amputations are attributed to diabetic foot ulcers, which constitute a primary…
- Conditions
- Diabetic Foot Disease, Diabete Mellitus, Mechanical Factor
- Trial name
- NCT07470255
- Testing
- Detection of the elastic modulus of the plantar skin
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Diabetes Mellitus, Type 2
A Study of the Efficacy and Safety of Supaglutide in Healthy Participants
This study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of the investigational drug Supaglutide proposed dosing once (or twice) weekly in Chinese healthy subjects.
- Trial name
- NCT03745885
- Testing
- Supaglutide injection
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shanghai Yinnuo Pharmaceutical Technology Co., Ltd.
Hypertension, Heart Failure
Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity
The study is aiming to document the long-term safety and effectiveness of renal denervation in patients with hypertension and other diseases characterized by elevated sympathetic drive.
- Conditions
- Hypertension, Heart Failure, Chronic Kidney Disease, Diabetes
- Trial name
- NCT01888315
- Testing
- Renal denervation with Symplicity Flex Medtronic/Ardian, Renal denervation with EnligHTN St. Jude Medical, Renal denervation with Paradise Recor
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Saarland
Diabetic Nephropathy
Nephropathy In Type 2 Diabetes and Cardio-renal Events
The NID-2 study, a multicentric study (21 centres enrolled), was planned in two phases: Phase 1(observational study, completed in September 2005): after the identification of a type-2 diabetic population with typical Diabetic…
- Trial name
- NID-2 (NCT00535925)
- Testing
- SoC therapy, irbesartan, ramipril
- Where
- Italy
- Volunteers
- 850 people
- Sponsor
- University of Campania Luigi Vanvitelli
Obesity, Diabetes Mellitus
Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool
Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.
- Conditions
- Obesity, Diabetes Mellitus, Fatty Liver, Nonalcoholic, Leaky Gut Syndrome
- Trial name
- METABIOM (NCT04067440)
- Testing
- Microbial Swab
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Universität des Saarlandes
Type 2 Diabetes Mellitus
The Efficacy and Safety of Different Doses of SY-004 in Patients With Type 2 Diabetes Mellitus
This is a multicenter, randomized, double-blind, placebo-controlled phase II clinical study in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT04217291
- Testing
- SY-004
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Suzhou Yabao Pharmaceutical R&D Co., Ltd.
Diabetic Nephropathy
Benfotiamine in Diabetic Nephropathy
The purpose of this study is to investigate the effect of benfotiamine supplementation in patients with diabetic nephropathy, and to determine whether it will slow down the progression to end-stage renal disease (ESRD).
- Trial name
- Benfo (NCT00565318)
- Testing
- Benfotiamine
- Where
- Netherlands
- Volunteers
- 86 people
- Sponsor
- University Medical Center Groningen
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