Clinical trials: Endocrine and Metabolic Diseases
Type 2 Diabetes Mellitus (T2DM)
A Study to Observe How Insulin Glargine 300 U/ml is Working and is Tolerated in Elderly Patients ≥75 Years of Age With Type 2 Diabetes
Primary objective: Glycemic control after initiation or switch to insulin glargine 300 U/ml in everyday clinical practice Secondary objective: Treatment satisfaction
- Trial name
- ELDERLY-T (NCT05607160)
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Sanofi
Type 2 Diabetes
Self-care Management Programme for Type 2 Adult DM Patients With Poor Glycemic Control
Type 2 diabetes becomes the most prevalence chronic disease worldwide. Most type 2 diabetes patient are under the care in public general out-patient clinic in Hong Kong.
- Trial name
- T2DM (NCT04092023)
- Testing
- nursing education
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Assessing the Impact of a Plant-Based Diet for Diabetes Prevention
The primary purpose of this study is to determine the sex-specific metabolic and molecular response, among adults with prediabetes, when moving from a Western Diet to plant-based diet.
- Trial name
- NCT06571279
- Testing
- Plant-based diet
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Jean L. Fry
Dyslipidemia Associated With Type II Diabetes Mellitus
Type 2 Diabetic Patients Maintained on Statin Therapy
Patients with diabetes mellitus (DM) are at increased risk of atherosclerotic cardiovascular disease (ACVD). The achievement of the LDL-C target with statins for the reduction of ACVD risk is recommended.
- Trial name
- NCT03784703
- Testing
- Atorvastatin 40 Mg Oral Tablet, Rosuvastatin 10 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Damanhour University
Type 2 Diabetes Mellitus
A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01 Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg, and to Evaluate the Effect of Food on the Pharmacokinetics of DA-1229_01 in Healthy Male Volunteers
This Phase I clinical study is to evaluate the safety/tolerability and pharmacokinetics of DA-1229_01 and to investigate the effect of food on the pharmacokinetics of DA-1229_01 in healthy male volunteers
- Trial name
- NCT02167061
- Testing
- DA-1229_01, E+M, DA-1229_01 fast
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Type 1 Diabetes
Investigation of Hyposafe H02 Device in Patients With Type 1 Diabetes
This clinical study is designed to collect data for further development of a hypoglycaemia notification algorithm. In addition, information regarding safety will be collected and analysed.
- Trial name
- NCT05495386
- Testing
- Hyposafe hypoglycaemia notification device (H02)
- Sponsor
- UNEEG Medical A/S
Diabetes
Reproducibility and Method Comparison Studies of the Quo-Test™ A1C System and the Quo-Lab A1C Test and CLIA Waiver Study of the Quo-Test™ A1C System
The Quo-Test A1C Analyzer and Reagent Test System (Quo-Test A1C System) are intended for the in-vitro quantitative determination of glycated hemoglobin in whole blood samples obtained from fingerstick or venous samples for…
- Trial name
- NCT01829061
- Where
- 3 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Quotient Diagnostics Limited
Diabetes Mellitus, Type 2, Severe Insulin Deficient Diabetes
The Effect of Glimepiride Compared With Sitagliptin as an add-on Therapy to Metformin in Severe Insulin Deficiency Diabetes
The purpose of the trial is to verify the effectiveness and safety of glimepiride compared with sitagliptin as an add-on therapy to metformin in severe insulin deficiency diabetes.
- Trial name
- NCT05386186
- Testing
- Glimepiride, Sitagliptin
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Peking University People's Hospital
Type 1 Diabetes, Rejection of Pancreas Transplant
Desensitization for Highly Sensitized Recipients of Pancreas Transplantation
This is an observational study for patients with type 1 diabetes, whom are already scheduled to have desensitization treatment to help increase the chance of receiving a pancreas transplant.The study staff will be looking at…
- Conditions
- Type 1 Diabetes, Rejection of Pancreas Transplant, Desensitization
- Trial name
- NCT00867386
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Northwestern University
Coronary Artery Disease, Type 2 Diabetes Mellitus
Comparison Between Pioglitazone and SES With type2 DM
Drug-eluting stents have been shown to decrease restenosis, but were associated with an increased rate of death, as compared with bare-metal stents.
- Trial name
- NCT00482183
- Testing
- Pioglitazone
- Volunteers
- 38 people
- Sponsor
- Showa University
Diabetes Mellitus, Type 2
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Empagliflozin in Chinese Female and Male Patients With Type 2 Diabetes Mellitus
the pharmacokinetics, pharmacodynamics and safety and tolerability of single and multiple oral doses of BI 10773 at low dose once daily (q.d.) and high dose q.d.
- Trial name
- NCT01316341
- Testing
- BI10773
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Boehringer Ingelheim
Obesity, Bariatrics
Comparing the Benefits and Harms of Three Types of Weight Loss Surgery -- The PCORnet® Bariatric Study
The main goal of this research project is to conduct a comparative effectiveness research study involving existing data in the PCORnet Common Data Model to provide accurate estimates of the 1-, 3-, and 5-year benefits and risks…
- Conditions
- Obesity, Bariatrics, Body Weight, Diabetes Mellitus
- Trial name
- PBS (NCT02741674)
- Testing
- Roux-en-y gastric bypass (RYGB) - historical, Adjustable gastric banding (AGB) - historical, Sleeve gastrectomy (SG) - historical
- Volunteers
- 65,093 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2
Vascular Function, Fish Protein Hydrolysates and Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease of abnormal carbohydrate metabolism which is related with high morbidity and mortality rates caused by its complications.
- Trial name
- NCT03318913
- Testing
- Fish protein hydrolysates
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Type 1 Diabetes Mellitus
A Study Evaluating Safety and Efficacy of BIOD-123 Compared to Insulin Lispro (Humalog®)
The purpose of this study is to evaluate the safety and efficacy of BIOD-123 compared to insulin lispro (Humalog®) when used as part of a basal-bolus regimen in patients with type 1 diabetes.
- Trial name
- NCT01686620
- Testing
- BIOD-123, Lispro (Humalog)
- Where
- 34 sites in United States
- Volunteers
- 132 people
- Sponsor
- Biodel
Type 2 Diabetes Mellitus
A Study to Assess Insulin Delivery With PaQ® in Patients With Type 2 Diabetes Mellitus
The purpose of the study is to obtain an assessment (efficacy, safety, and patient reported outcomes) of basal bolus insulin delivery with PaQ in insulin-using patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT02419859
- Testing
- PaQ® Insulin Delivery Device, Insulin, Asp(B28)-
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- CeQur Corporation
Type 2 Diabetes
Effect of Fish Oil on Adiposity and Atherogenic Factors in Type 2 Diabetic Women
1. whether the intake of n-3 PUFA has additional effects on insulin sensitivity and adiposity (total fat mass and adipocyte morphology and function) in T2D women. 2.
- Trial name
- NCT00371982
- Testing
- Fish oil (Maxepa)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Adrenal Hyperplasia, CAH - Congenital Adrenal Hyperplasia
Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia
This is a multicenter Phase 2, multiple dose, dose escalation study to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of SPR001 in adult patients with classic congenital adrenal hyperplasia (CAH).
- Trial name
- NCT03257462
- Testing
- SPR001
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Spruce Biosciences
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
An Evaluation of Home-Based Telemedicine Services
Tele-home health care, which providers for video interactions between home-based veterans and home care nurses, is a potentially useful adjunct to home care services.
- Conditions
- Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT00105846
- Testing
- Home care telemedicine
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes Mellitus, Obesity
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)
The molecular nature of insulin resistance in human muscle is still incompletely defined. Our data indicate that acetylation of mitochondrial proteins in humans is regulated by muscle contraction and is dysregulated in insulin…
- Trial name
- NCT03323827
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Arizona
WOUNDS
Efficacy Study of Ultrasound-Assisted Debridement to Influence Wound Healing
The UltraHeal Study is a randomized controlled trial to compare healing response of low frequency contact ultrasonic-assisted debridement in addition to best practice wound care to best practice wound care alone in a Vascular…
- Trial name
- UltraHeal (NCT01973361)
- Testing
- Ultrasound debridement, Best practice wound care
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
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