Clinical trials: Endocrine and Metabolic Diseases
Type 2 Diabetes
Oral Health Parameter-Based Diabetes Type 2 Indication Using Machine Learning
This study aims to explore the potential of using machine learning (ML) algorithms to predict Diabetes type2, based on oral health and demographic data.
- Trial name
- JFG (NCT06981286)
- Testing
- A dataset comprising participants withT2D will be used to evaluate the classification performance of various machine learning techniques.
- Where
- Sweden
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Blekinge Institute of Technology
Type 1 Diabetes Mellitus
A Study of an Automated Insulin Delivery System in Adult Participants With Type 1 Diabetes Mellitus (T1D)
The Automated Insulin Delivery (AID) System is an investigational insulin delivery device being developed for use for participants with diabetes.
- Trial name
- NCT03743285
- Testing
- AID System, Insulin Lispro
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eli Lilly and Company
Diabetes, Covid-19
Remote Continues Glucose Monitoring During the COVID-19 Pandemic in Quarantined Hospitalized Patients
This is a randomized controlled trial of isolated patients with diabetes admitted to Nordsjællands Hospital with or without COVID-19-pneumonia.
- Conditions
- Diabetes, Covid-19, Infection
- Trial name
- CGM-ISO (NCT04430608)
- Testing
- Dexcom G6
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Nordsjaellands Hospital
Polycystic Ovary Syndrome
Metformin Treatment in Polycystic Ovary Syndrome (PCOS)
PCOS occurs when a woman does not release an egg regularly each month, causing her periods to be irregular. Women with PCOS can also have increased hair growth on the face and body, acne, head balding, infertility, pre-diabetes…
- Trial name
- NCT02198417
- Testing
- Metformin ER
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Bariatric Surgery Candidate
Glycemic Index Variations In the Early Period Following Bariatric Surgery
The diverse community of gut microbes commonly referred to as the 'gut microbiome', is increasingly suggested to play significant roles in health and disease, and to affect even distant non-GI organs by metabolite signaling.
- Trial name
- NCT04263168
- Testing
- Continuous Glucose monitoring in the perioperative period
- Where
- Israel
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Type 2
BI 10773 add-on to Metformin in Patients With Type 2 Diabetes
The objective of the current study is to investigate the efficacy, safety and pharmacokinetics of five doses of BI 10773 compared to placebo given for 12 weeks as add-on therapy to on going metformin therapy in patients with T2DM…
- Trial name
- NCT00749190
- Testing
- BI 10773, sitagliptin
- Where
- 116 sites in United States, Argentina and 14 more
- Volunteers
- 495 people
- Sponsor
- Boehringer Ingelheim
Gestational Diabetes
Late Metabolic Effects of Metformin Therapy in Gestational Diabetes
Metformin in widely used as the treatment of gestational diabetes. However, it is not known whether exposure to metformin in utero has late metabolic effects on the child.
- Trial name
- DIARA2 (NCT02417090)
- Testing
- Insulin, Metformin
- Volunteers
- 173 people
- Sponsor
- Turku University Hospital
Type 2 Diabetes Mellitus
Effect of Nutritional Counseling Based on Diet Quality on Metabolic Control in Patients With Type 2 Diabetes Mellitus
Randomized clinical trial with outpatient patients with type 2 diabetes mellitus treated in Endocrinology Division, Hospital de Clinicas de Porto Alegre.
- Trial name
- NCT02488213
- Testing
- Nutritional Counseling, Usual Diet Guidance
- Where
- Brazil
- Volunteers
- 196 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiovascular Abnormalities, Chronic Kidney Diseases
Characteristics, Treatment, and Economic Burden of Patients With CVD,CKD or at High Cardiovascular Risk
The heavy disease burden is mainly due to diabetic complications. Diabetes is a major risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD).China has been the largest absolute disease burden of diabetes in…
- Conditions
- Cardiovascular Abnormalities, Chronic Kidney Diseases, Diabetes
- Trial name
- NCT03958760
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- West China Hospital
Obesity, Type 2 Diabetes
GOAL Life-Style Change Intervention to Prevent Type 2 Diabetes
Life-style change achieved in controlled experimental condition has been shown to prevent type 2 diabetes. The purpose of this study is to evaluate to what extent the life-style change can be achieved in a routine health care…
- Trial name
- NCT00398060
- Testing
- Cognitive-behavioral life-style counseling
- Where
- Finland
- Volunteers
- 389 people
- Sponsor
- Finnish Institute for Health and Welfare
Pancreatic Ductal Adenocarcinoma (PDAC), Pancreatic Neuroendocrine Tumor (NET)
Nutrition Intervention for Pancreatic Cancer
Patients with pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumor (NET)) commonly experience fat malabsorption due to exocrine pancreatic insufficiency (EPI) and leads to…
- Trial name
- NCT07554560
- Testing
- Structured Lipid Medical Food
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity, Type 2 Diabetes
An Efficacy and Safety Study of Beloranib in Obese Subjects With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate efficacy and safety of ZGN-440 (beloranib) in obese adult subjects with type 2 diabetes mellitus.
- Trial name
- NCT02324491
- Testing
- ZGN-440 for Injectable Suspension
- Where
- 16 sites in Australia
- Volunteers
- 152 people
- Sponsor
- Zafgen, Inc.
Type 1 Diabetes Mellitus (T1DM), End-Stage Renal Disease
Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden
The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease.
- Trial name
- NCT06883318
- Where
- Sweden
- Volunteers
- 115,000 people
- Sponsor
- Umeå University
Schizophrenia, Diabetes
Medication Reviews in Severe Mental Illness
This study aims to investigate the potential beneficial effects of a medication review by a clinical pharmacologist on patients with coexisting severe mental illness and diabetes.
- Conditions
- Schizophrenia, Diabetes, Metabolic Syndrome, Severe Mental Disorder
- Trial name
- NCT05243160
- Testing
- medication review
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Metabolic Disorders, Non-alcoholic Steatohepatitis
A Study to Understand the Safety, Tolerability, and Activity of Drug in Body Over a Period of Time of AZD2693, in Subjects of Non-Childbearing Potential in Overweight But Otherwise Healthy Subjects, and Healthy Chinese and Japanese Subjects
This Phase 1, first-in-human (FiH), single-ascending-dose (SAD) study, will assess the safety and tolerability and characterize the pharmacokinetics (PK) of AZD2693, following subcutaneous (SC) SAD administration of AZD2693 in…
- Trial name
- NCT04142424
- Testing
- AZD2693
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Pediatric Obesity, Type 2 Diabetes
Time Limited Eating in Adolescents With Type 2 Diabetes (KT2D)
To find the effectiveness of a diet plan (Time Limited Eating or TLE) on glycemic control, B-cell function, body fat, and body mass index (BMI) in adolescents with type 2 diabetes.
- Conditions
- Pediatric Obesity, Type 2 Diabetes, Time Restricted Eating
- Trial name
- NCT04536480
- Testing
- Time Limited Eating, Components Common to All Study Arms., Control
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Children's Hospital Los Angeles
Diabetes Mellitus, Type 1
Cellular Therapy for Type 1 Diabetes Using Mesenchymal Stem Cells
The goal of this study is to determine the safety and efficacy of fresh metabolically active allogeneic umbilical cord-derived mesenchymal stromal cells (UC-MSCs) for the treatment of new-onset type 1 diabetes (T1D) and to…
- Trial name
- NCT04061746
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Type 2 Diabetes
Financial Incentives And Nurse Coaching to Enhance Diabetes Outcomes (FINANCE-DM)-1
The objective of this protocol is to answer the questions: 1) Are financial incentives layered upon nurse education and home telemonitoring superior to nurse education and home telemonitoring alone in improving metabolic control…
- Trial name
- FINANCE-DM (NCT04203173)
- Testing
- FINANCE-DM, Active Comparator
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- State University of New York at Buffalo
Obesity, Obesity, Abdominal
Vestibular Stimulation to Trigger Adipose Loss Clinical Trial
There is an ongoing and worsening problem with obesity in the developed, and much of the developing world. Although it has long been realized that Western diets that are rich in sugar and fat play an important role in this, it…
- Conditions
- Obesity, Obesity, Abdominal, Metabolic Syndrome, Weight Loss
- Trial name
- VeSTAL (NCT03138369)
- Testing
- Vestibular nerve stimulator
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Neurovalens Ltd.
Diabetes Mellitus, Type 2
First Time in Human Study Using GSK2330672
The purpose of this study is to look at the safety and tolerability of increasing single doses of GSK2330672 in healthy volunteers.
- Trial name
- NCT01416324
- Testing
- 0.1 mg GSK2330672, 0.3 mg GSK2330672, 1 mg GSK2330672
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
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