Clinical trials: Endocrine and Metabolic Diseases
Diabetes Mellitus, Type 1
Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus
The long-term effects of high blood sugar include blindness, kidney failure, and nerve damage that can ultimately cause loss of limbs.
- Trial name
- NCT00187564
- Testing
- controlled-release oral alpha-lipoic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Insulin Dependent Diabetes, Diabetes (DM)
Integrating New Skills Into Diabetes Education With CGM
This study is designed to test the preliminary efficacy of a three-stage continuous glucose monitor (CGM) integration program for older adults who are taking insulin.
- Conditions
- Insulin Dependent Diabetes, Diabetes (DM), Diabetes (Insulin-requiring, Type 1 or Type 2), Diabetes Education
- Trial name
- INSIDE-CGM (NCT07463209)
- Testing
- Three-stage CGM integration program, One-time clinic-based CGM training, Self-directed CGM training
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetic Macular Edema
A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema
The objective of this study is to investigate the safety and efficacy of minocycline as a microglia inhibitor in individuals with diabetic macular edema (DME).
- Trial name
- NCT01120899
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Eye Institute (NEI)
Prediabetes, microRNA
Effect of Exercise on MiR-126 in Individuals With Prediabetes
This study aims to investigate the effect of a structured exercise program on microRNA-126 (miR-126) expression in individuals with prediabetes.
- Conditions
- Prediabetes, microRNA, Exercise
- Trial name
- EMiR-126-PD (NCT06809257)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Diabetes Mellitus, Diabetes Mellitus, Type 1
Umbilical Cord Mesenchymal Stem Cells Infusion for Initial Type 1 Diabetes Mellitus
The purpose of this study is to determine whether umbilical cord Mesenchymal Stem Cells of treatment for initial type 1 diabetes is safe and effective.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Mesenchymal Stem Cells, Umbilical Cord
- Trial name
- NCT01219465
- Testing
- umbilical cord mesenchymal stem cells
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qingdao University
Diabetes Mellitus, Type 1
Imaging Inflammation in Autoimmune Diabetes
The purpose of this study is to determine whether magnetic resonance imaging (MRI) with ferumoxtran-10 can be used to detect changes in the pancreas associated with autoimmune diabetes.
- Trial name
- NCT00585936
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes
Placebo Controlled Dose-Response Study of Rivoglitazone in Type 2 Diabetes
The purpose of this study is to assess the efficacy response of rivoglitazone HCl on the change in HbA1c after 12 weeks of treatment in patients with type 2 diabetes.
- Trial name
- NCT00575471
- Testing
- Rivoglitazone HCl
- Where
- 3 sites in Japan
- Volunteers
- 250 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Diabetes, Erectile Dysfunction
The Prevalence of Erectile Dysfunction (ED) and ED Related Quality of Life of Diabetic Men
Adult diabetic patients aged above 20 attending the diabetic clinic of National Taiwan University Hospital are invited to attend a face to face screening and interview.
- Trial name
- NCT00173134
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Cushing Syndrome
A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome
This is a Phase 3, double-blind, placebo-controlled, randomized-withdrawal study to assess the efficacy, safety and pharmacokinetics (PK) of relacorilant in patients with endogenous Cushing syndrome and concurrent type 2 diabetes…
- Trial name
- GRACE (NCT03697109)
- Testing
- Relacorilant
- Where
- 64 sites in United States, Austria and 9 more
- Volunteers
- 152 people
- Sponsor
- Corcept Therapeutics
Diabetes Mellitus
Ramadan Flash Glucose Monitoring Study
Many Muslim patients with diabetes observe dawn to sunset fasting during the month of Ramadan. Hyperglycaemia and hypoglycaemia are possible problems amongst these patients.
- Trial name
- RFGM (NCT04356898)
- Testing
- No intervention
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 321 people
- Sponsor
- Imperial College London Diabetes Centre
Pregnancy, Gestational Diabetes Mellitus, Class A2
Intrapartum Glycemic Control in GDMA2
This is a randomized, parallel, controlled, non-inferiority trial to assess the impact of a tight versus a more liberalized intrapartum glycemic control in gestational diabetic mothers on neonatal glycemia.
- Conditions
- Pregnancy, Gestational Diabetes Mellitus, Class A2, Neonatal Hypoglycemia
- Trial name
- NCT05647798
- Testing
- Blood sugar check every 2 hours, Blood sugar check every 4 hours
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inova Health Care Services
Osteoporosis, Osteitis Deformans
Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders
The purpose of this study is to determine whether the serum levels of certain calcium-binding proteins may be helpful in the diagnosis and management of metabolic bone diseases.
- Conditions
- Osteoporosis, Osteitis Deformans, Parathyroid Diseases
- Trial name
- NCT00403598
- Where
- Israel
- Sponsor
- Sheba Medical Center
Peripheral Neuropathy
The Effect of Plantar Vibration on the Progression of Peripheral Neuropathy
The purpose of this study is to assess the effect of vibration of the plantar surface of the foot on peripheral neuropathy.
- Trial name
- NCT00822198
- Testing
- plantar vibration
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Binghamton University
Type 1 Diabetes,, Bone
Skin Blood Flow in Patients With Type 1 Diabetes Mellitus Compared to Normal Controls
The effects of high serum glucose on bone could be direct or could be indirect through its effects on the microvasculature. Previous studies by Rendell et al and Brugler et al have found significant differences in skin blood flow…
- Trial name
- NCT01592539
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Creighton University
Obesity, Maternal, Gestational Diabetes
Nutrition Optimization and Community Upliftment for Postpartum Recovery
The goal of this clinical trial is to better understand how different strategies, timing, and enhancements to medically tailored food delivery will address structural inequities in the food environment, empower communities to…
- Trial name
- NOURISH-GDM (NCT06445530)
- Testing
- MFeast ENHANCED, MFeast Usual Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 2
Telemedical Devices in the Management of Type 2 Diabetes Mellitus to Improve Diabetic Control and Quality of Life
The aim of this study is to understand, in adult patients with Type 2 diabetes mellitus, if the use of telemedicine (monitoring and treatment without patients having to attend a healthcare facility) and home-based care is more…
- Trial name
- NCT04038528
- Testing
- telemonitoring of T2DM
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Centro Studi Internazionali, Italy
Type 2 Diabetes
Safety and Efficacy Study to Compare Vildagliptin to Pioglitazone as Adding on Metformin in Type 2 Diabetes
The purpose of this study is to compare the effect of 16 weeks treatment with vildagliptin to pioglitazone as add-on the therapy to metformin in patients with type 2 diabetes inadequately controlled with metformin monotherapy.
- Trial name
- NCT01882907
- Testing
- vildagliptin, Pioglitazone
- Where
- 15 sites in South Korea
- Volunteers
- 287 people
- Sponsor
- Pusan National University Hospital
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy
Primary Objective: To demonstrate the non-inferiority of Sotagliflozin 400 milligrams (mg) compared to Glimepiride on hemoglobin A1c (HbA1c) reduction at Week 52 in participants with Type 2 Diabetes (T2D) who have inadequate…
- Trial name
- SOTA-GLIM (NCT03332771)
- Testing
- Sotagliflozin (SAR439954), Glimepiride, Metformin
- Where
- 142 sites in United States, Bulgaria and 2 more
- Volunteers
- 954 people
- Sponsor
- Lexicon Pharmaceuticals
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Single Ascending Dose Study of MK-1092 in Healthy Participants and in Participants With Type 1 and Type 2 Diabetes Mellitus (MK-1092-001)
This is an active- and placebo-controlled, single-site, four-part trial of MK-1092 in healthy adult participants, in participants with type 1 diabetes mellitus (T1DM), and in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03170544
- Testing
- MK-1092, 4.0 nmol/kg, MK-1092, 8.0 nmol/kg, MK-1092, 16 nmol/kg
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes, Diabetes Mellitus, Type 1
Bioequivalence of Two NovoLog® Formulations in Subjects With Type 1 Diabetes
This trial is conducted in the United States of America (USA). The aim of this trial is to evaluate the clinical performance of two formulations of insulin aspart (NovoLog®) in subjects with type 1 diabetes.
- Trial name
- NCT01464099
- Testing
- insulin aspart
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Novo Nordisk A/S
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