Clinical trials: Endocrine and Metabolic Diseases
Diabetes Mellitus, Type 1
A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes
This study is testing the effect of a new study medicine NNC0194-0499 in type 1 diabetes. The purpose of the study is to compare the effect of NNC0194-0499 on the blood sugar levels of participants with type 1 diabetes when taken…
- Trial name
- NCT07087795
- Testing
- NNC0194-0499, Semaglutide
- Where
- Germany
- Volunteers
- 96 people
- Sponsor
- Novo Nordisk A/S
Gestational Diabetes
Active Patient GDM
Among women with GDM, the investigators will determine if a strategy of (1) a website-based information and motivational resource bank; (2) biosensor/ePlatform-based physical activity and GWG tracking; and/or (3) a health coach…
- Trial name
- NCT03802877
- Testing
- Resource bank, ePlatform, Health coach
- Where
- 6 sites in Canada
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Diabetes Mellitus Type 1, Remission of Type 1 Diabetes
The Influence of Partial Remission Phase of Type 1 Diabetes on Patient Outcome
Natural course of diabetes mellitus involves gradual reduction of β cell mass within islets of Langerhans in the pancreas. Symptoms of diabetes present when the mass of insulin-producing cells reaches a point where insulin…
- Conditions
- Diabetes Mellitus Type 1, Remission of Type 1 Diabetes, Chronic Complications of Diabetes
- Trial name
- POZREM (NCT02220257)
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Poznan University of Medical Sciences
Diabetes, Gastroparesis With Diabetes Mellitus
PET Imaging to Delineate Macrophage Activation in Diabetic Gastroparesis
Macrophage-driven immune dysregulation has been shown to be involved in pathophysiology of diabetic gastroparesis. Currently, there are no non-invasive ways to study macrophage activation in humans.
- Trial name
- NCT04762719
- Testing
- PET/CT Scan with 11C-ER176, Core biopsy of gastric muscle
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Bone Marrow Failure Syndrome, Thalassemia
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation
In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum…
- Conditions
- Bone Marrow Failure Syndrome, Thalassemia, Sickle Cell Disease, Diamond Blackfan Anemia
- Trial name
- NCT03513328
- Testing
- Thiotepa--single daily dose, Thiotepa--escalated dose
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Diabetes, Care Delivery
Impact of Individualized Structured Information Provision to the Patients, on Diabetes Related Outcomes
Health professionals usually lead in the management of long term conditions such as Diabetes. In a conventional professionally driven compliance model of care, patients may be placed in a secondary role.
- Trial name
- WICKED (NCT02200965)
- Testing
- My Diabetes, My Information, My Plan Document
- Where
- United Kingdom
- Volunteers
- 17,002 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Type 2 Diabetes
Conditional Cash Transfer Intervention to Improve T2DM
This study will test the preliminary efficacy of diabetes-tailored CCT (DM-CCT), which will be conditional on participating in biweekly (every two weeks), nurse-led, virtual diabetes education/skills training and stress/coping…
- Trial name
- DMCT (NCT05559892)
- Testing
- DM-CCT, DM-UCT
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Type 2, Overweight or Obesity
Effects of Different ''Exercise Snacking'' Modalities on Glycemic Control in Patients With Type 2 Diabetes
Patients with type 2 diabetes (T2DM) face an increased risk of obesity, hypertension, and hyperglycemia, attributed to impaired cardiorespiratory fitness, elevated Hb1AC levels, and impaired lipid status.
- Trial name
- NCT06146036
- Testing
- HIIT snacks, Sprint snacks, Control
- Volunteers
- 20 people
- Sponsor
- University of Nis
Diabetes Mellitus, Type 1, Diabetes
The T1D Exchange Registry
The T1D Exchange Registry is a research study, conducted over time, for individuals with type 1 diabetes and their supporters. Participants volunteer to provide their data for research (for example, by answering questions in…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes, Type 1 Diabetes, Diabetes Mellitus
- Trial name
- T1D Registry (NCT04629586)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- T1D Exchange, United States
Healthy Subjects, Obesity
A Phase 1 Study of HEC88473 Injection in Healthy Subjects, Obese Subjects and T2DM Subjects
This is a single-center, randomized, double-blind, placebo-controlled, escalating single-dose and multiple-dose study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HEC88473 injection in healthy…
- Conditions
- Healthy Subjects, Obesity, T2DM (Type 2 Diabetes Mellitus)
- Trial name
- NCT05943886
- Testing
- HEC88473 injection
- Where
- China
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Dongguan HEC Biopharmaceutical R&D Co., Ltd.
Gestational Diabetes Mellitus
Home-Ultrasound in Routine High-Risk Care of Patients With Gestational Diabetes Mellitus (GDM)
This study evaluates the impact of incorporating home-ultrasound (home-US) devices into telemedicine care for patients with gestational diabetes mellitus (GDM).
- Trial name
- NCT07158970
- Testing
- Use of the Pulsenmore home ultrasound device for fetal assessment, guided remotely by a physician.
- Where
- Israel
- Volunteers
- 90 people
- Sponsor
- Wolfson Medical Center
Type 2 Diabetes, Mental Health Issue
Community-based CBT and T2D in Latino Population
The purpose of this project is to develop and test the acceptance and clinical efficacy of a cognitive behavioral therapy (CBT)-based lifestyle intervention, to help manage obesity and diabetes-related health outcomes, provided…
- Conditions
- Type 2 Diabetes, Mental Health Issue, Quality of Life, Weight Loss
- Trial name
- NCT05222373
- Testing
- CBT-based lifestyle intervention
- Where
- United States
- Sponsor
- Washington University School of Medicine
Diabetes
Diabetes Outcomes and Unmet Resources
This study will refine and test the effectiveness of CareAvenue, an automated e-health tool that informs and activates patients with uncontrolled diabetes to take steps in accessing resources and engaging in self-care.
- Trial name
- NCT03950973
- Testing
- CareAvenue, Guest Assistance Program
- Where
- United States
- Volunteers
- 667 people
- Sponsor
- University of Michigan
Diabetes Type 2, Diabetes
Study Evaluating the Metabolic Effects of pulsENDO Therapy in Adults With Type 2 Diabetes
This is a prospective, multicenter, randomized, double-blind, sham-controlled, adaptive study evaluating the pulsENDO system in individuals with type 2 diabetes (T2D) inadequately controlled on non-insulin glucose-lowering…
- Conditions
- Diabetes Type 2, Diabetes, Diabetes (DM), Weight Change
- Trial name
- pulsENDO (NCT07768631)
- Testing
- pulsENDO Therapy
- Volunteers
- 320 people
- Sponsor
- Endogenex, Inc.
Type 1 Diabetes
Islet Transplantation in Type 1 Diabetic Patients
Our hypothesis is that a successful clinical islet transplant program can be established at the University of Wisconsin using a steroid -free, sirolimus- and low dose tacrolimus - based immunosuppressive drug regimen (Edmonton…
- Trial name
- NCT00214253
- Testing
- Thiazolidinedione
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Wisconsin, Madison
Metabolic Syndrome, Diabetes
Biomarkers of Metabolic Syndrome and Prediabetes
The purpose of this study is to investigate the feasibility of using salivary biomarkers to screen for complications of metabolic syndrome including prediabetes.
- Conditions
- Metabolic Syndrome, Diabetes, Prediabetes, Hypertension
- Trial name
- NCT01086137
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- West Virginia School of Osteopathic Medicine
Type 1 Diabetes
Resistance Training in Type 1 Diabetes Mellitus
The purpose of this study is to learn how different resistance training programs affects blood sugar in young athletes with T1DM.
- Trial name
- NCT05315037
- Testing
- Resistance Training
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Louisville
Hypertension, Diabetes
Flavanol-Rich Cocoa and Cerebral Blood Flow
The purpose of the study is to learn whether or not cocoa has a beneficial effect on blood flow to the brain in older subjects with diabetes mellitus or hypertension (high blood pressure).
- Trial name
- NCT00825695
- Testing
- cocoa
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Brigham and Women's Hospital
Blindness, Cataract
Long Term Follow-Up of Diabetic Retinopathy
The efficacy of laser photocoagulation treatment for diabetic retinopathy has been demonstrated by several National Eye Institute (NEI) sponsored clinical trials.
- Conditions
- Blindness, Cataract, Diabetes Mellitus, Diabetic Retinopathy
- Trial name
- NCT00001395
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Eye Institute (NEI)
Type 2 Diabetes Mellitus, Hypercholesterolemia
Effects of Metformin Hydrochloride (HCl) in Combination With Colesevelam HCl, Compared to Metformin HCl Alone, in Patients With Type 2 Diabetes Mellitus and the Effects of Colesevelam HCl on Lipids and Glucose on Pre-diabetic Patients.
This is a 16-week double-blind, placebo-controlled (for colesevelam hydrochloride (HCl)) study in the type 2 diabetic subjects and pre-diabetic subjects.
- Conditions
- Type 2 Diabetes Mellitus, Hypercholesterolemia, Pre-diabetes
- Trial name
- NCT00570739
- Testing
- Metformin HCl tablets and Colesevelam tablets, Colesevelam
- Where
- 31 sites in United States, Colombia and 2 more
- Volunteers
- 502 people
- Sponsor
- Daiichi Sankyo
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