Clinical trials: Endocrine and Metabolic Diseases
Hyponatremia
Study of IV YM087 to Assess Efficacy and Safety in Patients With Euvolemic or Hypervolemic Hyponatremia
This study will investigate the application of a vasopressin antagonist in the treatment of hyponatremia most likely caused by inappropriate AVP secretion.
- Trial name
- NCT00380575
- Testing
- YM087
- Where
- 47 sites in United States, Canada and 2 more
- Volunteers
- 84 people
- Sponsor
- Cumberland Pharmaceuticals
Diabetes Mellitus Type 2
Effect of Androgel on Type 2 Diabetic Males With Hypogonadism
This is to study the effect of replacing testosterone on different inflammatory cells in type 2 diabetics with low testosterone levels.
- Trial name
- NCT00350701
- Testing
- androgel, androgel 10g
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University at Buffalo
Hypertension, Hormone Disturbance
12 Weeks of Resistance Band Exercise Impacts on Adiposity, Hormones, and Blood Pressure in Postmenopausal Women
The purpose of this study was to examine the impacts of a 12-week resistance band exercise program on body composition, aging-related hormones, and blood pressure in postmenopausal women with stage 1 hypertension.
- Conditions
- Hypertension, Hormone Disturbance, Adiposity
- Trial name
- NCT03919201
- Testing
- Resistance band exercise intervention, No exercise intervention group
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Pusan National University
Diabetes Mellitus, Type 2
Extension to a Study on the Efficacy and Safety of Vildagliptin Compared to Rosiglitazone in Drug Naive Patients With Type 2 Diabetes
This is an 80-week extension to a study to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to rosiglitazone in lowering overall blood glucose levels in people with type 2 diabetes who have not…
- Trial name
- NCT00138619
- Testing
- vildagliptin
- Where
- 2 sites in United States, Germany
- Volunteers
- 478 people
- Sponsor
- Novartis
Type 1 Diabetes
Evaluation of The Postprandial Impact of Automated Priming Bolus for Full Closed Loop Insulin Delivery
The purpose of this study is to understand the impact of the automated priming boluses on the safety and feasibility of a new fully automated AP controller.
- Trial name
- Rocket-BPS (NCT05528770)
- Testing
- FCL+BPS, FCL
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Marc Breton
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Type 2 Diabetes Mellitus
Efficacy and Safety Study of MP-513 in Combination With Thiazolidinedione in Patients With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety of MP-513 (Teneligliptin) in combination with thiazolidinedione (pioglitazone) in patients with type 2 Diabetes for 12 weeks administration and to evaluate the…
- Trial name
- NCT01026194
- Testing
- Teneli / Teneli + pio
- Where
- Japan
- Volunteers
- 204 people
- Sponsor
- Tanabe Pharma Corporation
Diabetes Mellitus, Type 1
PINIT Study: Primary Intranasal Insulin Trial
Type 1 diabetes (T1D) results from an autoimmune destruction of the insulin-producing beta cells. Administration of mucosal insulin in islet autoantibody-negative children who are genetically predisposed for T1D offers the…
- Trial name
- NCT03182322
- Testing
- intranasal insulin
- Where
- 2 sites in Germany
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Diabetes Mellitus
Special Drug Use Investigation of Glucobay OD
The objective of this study is to assess the efficacy and safety under practical use of Glucobay OD. A total of 5,000 patients are to be enrolled to the study and assessed during 1 year observation period.
- Trial name
- NCT01685502
- Testing
- Glucobay ODT (Acarbose, BAYG5421)
- Where
- Japan
- Volunteers
- 2,289 people
- Sponsor
- Bayer
Hypertension, Diabetes Mellitus
Examining Digital Health Care Delivery Models Through Medicaid Collaborative
The purpose of this study is to examine the intervention effectiveness and dissemination of digital health care delivery models for improving selected health outcomes in the Medicaid population.
- Conditions
- Hypertension, Diabetes Mellitus, Maternal Health
- Trial name
- MIC (NCT05555095)
- Testing
- digital health delivered multicomponent intervention
- Where
- United States
- Volunteers
- 22,340 people
- Sponsor
- OSF Healthcare System
Diabetes Mellitus, Type 1
Comprehensive Care in Type 1 Diabetes and Associated Outcomes
Quasi-experimental, retrospective, before and after study, with a control group, to evaluate the effect of an intervention based on disease management, on metabolic control and hospitalizations, in a group of patients with type…
- Trial name
- AIDDA (NCT03835195)
- Testing
- Diabetes Disease Management Program, Usual Care Process
- Where
- Colombia
- Volunteers
- 50 people
- Sponsor
- Universidad de Antioquia
Diabetes Mellitus
Bioequivalence Study of the Fixed Dose Combination of 5 mg Saxagliptin and 500 mg Metformin XR Tablet (Manufactured in Mt Vernon, IN) Relative to 5 mg Saxagliptin Tablet and 500 mg Metformin XR Tablet (Manufactured in Evansville, IN)
The purpose of this study is to demonstrate bioequivalence (BE) of a 5 mg saxagliptin/500 mg metformin extended release (XR) fixed-dose combination (FDC) tablet (manufactured in Mt Vernon, Indiana [IN]) to coadministered 5 mg…
- Trial name
- NCT01192139
- Testing
- saxagliptin, metformin XR, saxagliptin + metformin XR (FDC tablet)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Diabetes, Diabetes Mellitus, Type 2
Trial to Compare NNC0123-0000-0338 in a Tablet Formulation and Insulin Glargine in Subjects With Type 2 Diabetes Currently Treated With Oral Antidiabetic Therapy
This trial is conducted in Europe. The aim of this trial is to compare NNC0123-0000-0338 (insulin-338) in a tablet formulation and insulin glargine in combination with metformin with or without DPP-4 inhibitor in subjects with…
- Trial name
- NCT02470039
- Testing
- insulin 338 (GIPET I), insulin glargine
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Efficacy of TAK-559 in Treating Subjects With Type 2 Diabetes Mellitus
The purpose of this study was to determine the safety and efficacy of TAK-559, once daily (QD), in Type 2 Diabetes subjects.
- Trial name
- NCT00763022
- Testing
- TAK-559
- Volunteers
- 302 people
- Sponsor
- Takeda
Diabetes Mellitus, Type 2, Metabolic Syndrome
MK0916 in Patients With Type 2 Diabetes and Metabolic Syndrome (0916-005)
This study will test the safety and effectiveness of MK0916 in patients with Type 2 Diabetes Mellitus and Metabolic Syndrome. This is an early phase trial and some specific protocol information is in progress and not publicly…
- Trial name
- NCT00543595
- Testing
- MK0916
- Volunteers
- 154 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Prevention of Type 2 Diabetes Amongst South Asians With Central Obesity and Prediabetes
The investigators' general goal is to identify approaches to risk stratification and health promotion through lifestyle modification that are acceptable, effective and efficient for prevention of T2D in South Asian communities…
- Trial name
- iHealth-T2D (NCT02949739)
- Testing
- Intensive lifestyle modification
- Where
- United Kingdom
- Volunteers
- 5,244 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Type 1 Diabetes
Healthy And Positive Pathways for Young People With Type 1 Diabetes (HAPPY T1D)
In this 2-year randomized clinical trial, we will implement and assess the impact of a behavioral/psychoeducational intervention to reduce diabetes distress and improve glycemic outcomes in adolescents and young adults, aged…
- Trial name
- NCT05413239
- Testing
- Psychoeducation to reduce diabetes distress and improve glycemic outcomes
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- Joslin Diabetes Center
Type 2 Diabetes
Different Diets in Different Diabetes - 4DI PLAN'EAT Pilot Study
The goal of this clinical trial is to learn whether a diet adapted to a person's cultural background, combined with a supervised physical activity programme, improves blood sugar control better than standard dietary advice in…
- Trial name
- 4DI PLAN'EAT (NCT07887477)
- Testing
- Culturally adapted Mediterranean diet, Supervised walking programme, Standard dietary and behavioural counselling
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- University of Bologna
Diabetes, Metabolic Syndrome x
Botanical Oil Supplementation in Diabetic and Metabolic Syndrome Subjects
This study will compare how well a combination of borage and echium oils will reduce inflammation compared to fish oils and placebo oil in subjects that are diabetic or have metabolic syndrome.
- Trial name
- NCT01145066
- Testing
- borage/echium oil combination, fish oil, corn oil
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus
Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)
The purpose of this study is to compare the effects of 2.0 mg exenatide once weekly and insulin glargine, titrated to glucose targets using the algorithm described by Yki- Järvinen et al.(2007), with respect to glycemic…
- Trial name
- NCT00641056
- Testing
- Exenatide Once Weekly, Insulin Glargine
- Where
- 75 sites in United States, Australia and 14 more
- Volunteers
- 467 people
- Sponsor
- AstraZeneca
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