Clinical trials: Endocrine and Metabolic Diseases
Obesity, Type 2 Diabetes Mellitus
XW004 To Evaluate the Safety, Tolerability, PK, and PD of Oral Ecnoglutide Tablet in Healthy Adults
XW004 is an acylated human glucagon-like peptide 1 (GLP-1) analogue and is being developed for type 2 diabetes mellitus (T2DM) and obesity management.
- Trial name
- NCT05184322
- Testing
- T2026, Oral ecnoglutide tablet
- Where
- Australia
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Sciwind Biosciences APAC CO Pty. Ltd.
IUGR, Gestational Diabetes
PED NEONAT 20-000599 Fetal Body Composition
Obesity is an ongoing public health problem that is difficult to treat. There is evidence that obesity has fetal origins. Body composition, including visceral, subcutaneous, brown, and hepatic fat have been found to be important…
- Conditions
- IUGR, Gestational Diabetes, Pregnancy Related
- Trial name
- NCT04508751
- Testing
- 3T "Free-Breathing" Fetal Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes Mellitus, Type 2
Cognitive Training for Diabetes Self-Management
The overall objective of this study is to determine the effects of a comprehensive cognitive rehabilitation intervention on biological, cognitive, and diabetes self-management outcomes.
- Trial name
- NCT04831775
- Testing
- Memory, Attention, and Problem Solving Skills for Diabetes, Brain Games
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Type 2 Diabetes Mellitus
Intergenerational mHealth Diabetes Program OPPORTUNITIES PROGRAM IN TAIWAN
The primary purpose of the study is to understand the potential of mobile computing technology to improve chronic disease self-management, quality of life, and health outcomes of older adults to prevent or alleviate future…
- Trial name
- IMTOP (NCT02971241)
- Testing
- Intergenerational Mobile Technology Opportunities Program
- Where
- 2 sites in Taiwan
- Volunteers
- 617 people
- Sponsor
- University of Southern California
Type 2 Diabetes Mellitus
A Study to Examine the Pharmacokinetics, Tolerability, Safety and Efficacy of Exenatide Once Weekly Suspension
This study is designed to evaluate the pharmacokinetics, tolerability, and safety of exenatide once weekly suspension in both healthy subjects and in subjects with type 2 diabetes.
- Trial name
- NCT00894322
- Testing
- exenatide once weekly
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type 1
Recurrent Hypoglycemia in Type 1 Diabetes (Aim 2)
This study will explore the cerebral mechanisms of impaired awareness of hypoglycemia (IAH) in type 1 diabetics following exposure to experimental recurrent hypoglycemia (HG).
- Trial name
- NCT04387422
- Testing
- Experimental hyperglycemia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 2
Raclopride-PET/MRT
Cerebral insulin resistance plays an important role in the development of obesity and diabetes mellitus type 2. The aim of this project is to examine the effect of human nasal insulin on the dopaminergic system.
- Trial name
- NCT03637075
- Testing
- intranasal insulin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Atrial Fibrillation, Type 2 Diabetes
The Effect of High-Intensity Interval Training on Glucose Variability and Atrial Fibrillation Symptoms
The incidence of atrial fibrillation (AF), the most common heart rhythm disorder, is increasing. The symptoms of AF include: unpleasant heartbeats; difficulty breathing; tiredness; dizziness; and, reduced exercise capacity.
- Trial name
- Glucose-AF (NCT04190212)
- Testing
- High-intensity interval training + standard care
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hyperprolactinemia, Puberty Disorders
PROSA: Prolactin, Sex Hormones, Growth and Metabolic Biomarkers in Children and Adolescents on Antipsychotics
The objectives of this study are: 1. To determine the prevalence and degree of hyperprolactinemia in children and adolescents aged 7-18 years receiving antipsychotic medications 2.
- Conditions
- Hyperprolactinemia, Puberty Disorders, Metabolic Syndrome, Growth Disorders
- Trial name
- PROSA (NCT05033119)
- Where
- 3 sites in Denmark
- Volunteers
- 90 people
- Sponsor
- Ulla Schierup Nielsen
Vitamin D Deficiency, Secondary Hyperparathyroidism
Vitamin D Status in Males in Jerusalem Area and Its Correlation to Parathyroid Hormone (PTH) Level and Bone Mineral Density
Because of its high sun exposure, Israel was traditionally supposed to be protected from vitamin D deficiency, and the country food products hardly contain vitamin D supplements.
- Conditions
- Vitamin D Deficiency, Secondary Hyperparathyroidism, Osteomalacia
- Trial name
- NCT01025128
- Testing
- 25 OH vitamin D
- Where
- Israel
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Type 2 Diabetes Mellitus
Efficacy and Safety of Efpeglenatide Versus Placebo in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin Alone or in Combination With Sulfonylurea
Primary Objective: To demonstrate the superiority of once weekly injection of efpeglenatide in comparison to placebo in glycated hemoglobin (HbA1c) change in participants with type 2 diabetes mellitus (T2DM) inadequately…
- Trial name
- AMPLITUDE-S (NCT03770728)
- Testing
- Efpeglenatide SAR439977, Background therapy: Metformin alone or in combination with SU
- Where
- 48 sites in United States, China and 1 more
- Volunteers
- 312 people
- Sponsor
- Sanofi
Dry Eye Syndrome, Diabetes Mellitus Type 2
Comparison of Ocular Surface Features in Patients With Diabetes and Dry Eye Syndrome
The study aims to compare the differences of ocular surface features in controls and patients with diabetes and dry eye syndrome, to thoroughly evaluate the ocular surface health of diabetics, and to find out the relationship…
- Trial name
- NCT03576300
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Acromegaly, Type 2 Diabetes Mellitus
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
Growth hormone (GH) and Insulin-like growth factor-I (IGF-I) secretion are altered in acromegaly and type 2 Diabetes Mellitis (DM).
- Trial name
- NCT00915954
- Testing
- Oral Glucose Tolerance Test, Subcutaneous administration of recombinant human IGF-1
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Type 2 Diabetes Mellitus
Comparing Internet Blood Glucose Monitoring System and Continuous Glucose Monitoring System
Management of type 2 diabetes is an ongoing challenge for patients and their doctors. In order to prevent short and long term complications, patients need to monitor and control their blood sugar levels.
- Trial name
- NCT01162694
- Testing
- Remote Blood Glucose Monitoring, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Endocrine Research Society
Diabetes Mellitus
The Effect of Message Framing in Diabetic Foot Self-Management
This study aims to assess how effective gain- and loss-framed messages are in improving diabetic foot care behaviors and increasing self-efficacy levels compared to routine foot care messages.
- Trial name
- NCT06813794
- Testing
- Gain- Framed Messages, Lost Framed Messages
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people
- Sponsor
- Ataturk University
Diabetes
Effect of Apelin on Insulin Sensitivity in Type 2 Diabetic Volunteers
Preclinical studies have demonstrated in mouse models that (PYR1)-apelin-13 exerts a glucose-regulating action in vivo. The (PYR1)-apelin-13 effect on insulin sensitivity in healthy overweighed volunteers has been previously…
- Trial name
- APELINS-2 (NCT02724566)
- Testing
- apelin
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Toulouse
Chronic Disease
A Longitudinal Survey of Health in Bolivia
The purpose of the study is to gather baseline surveillance data about the current health status of adults with chronic health conditions in La Paz and El Alto, Bolivia and identify barriers to the management of NCDs during…
- Trial name
- NCT02384356
- Where
- 2 sites in Bolivia
- Volunteers
- 2,000 people
- Sponsor
- University of Michigan
Type 2 Diabetes
CGM Evaluation of Glucose Excursions in Basal Insulin Treated T2DM at Fasting Glucose Target
This is a trial to determine if patients who are well controlled and on basal insulin are treated with excessive basal dose.
- Trial name
- NCT01548222
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Diabetes Care Center
Hypogonadism, Diabetes
Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Trial.
Background: Men≥65 years often produce lower levels of testosterone, meaning there is less testosterone circulating to the tissues of the body.
- Conditions
- Hypogonadism, Diabetes, Sarcopenia, Osteoporosis
- Trial name
- NCT00104572
- Testing
- Androgel (Testosterone Gel), Anastrozole (Aromatase Inhibitor), Calcium Cardone 500mg with vitamin D 400 IU
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Type 1 Diabetes Mellitus
Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin
This is a pilot study to examine and compare the efficacy of supervised injections of long acting insulins degludec and glargine to protect youth with poorly controlled type 1 diabetes (T1D) from development of ketones.
- Trial name
- NCT03400501
- Testing
- Insulin Degludec, Insulin Glargine
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Yale University
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