Clinical trials: Endocrine and Metabolic Diseases
Platelet Indices, Type 2 Diabetes
Platelet Changes in Type 2 Diabetes
This study examines changes in platelet indices in people with type 2 diabetes compared to healthy people. It checks if these changes relate to inflammation markers (like hs-CRP) and blood sugar control.
- Conditions
- Platelet Indices, Type 2 Diabetes, Inflammatory Markers
- Trial name
- NCT07363122
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Artery Disease, Diabetes Mellitus, Type 2
PIPAF Platelets in the Pathogenesis of Ageing Associated Frailty
This is a prospective observational study aimed at testing the existence of an association between frailty, inflammatory status, and degree of platelet activation and reactivity in elderly subjects with type 2 diabetes or…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Alzheimer Disease
- Trial name
- PIPAF (NCT05798637)
- Testing
- Standard of care
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Type 2 Diabetes, Renal Impairment
A Clinical Trial of the Study Medicine (PF-07081532) in People With Diabetes and Kidney Dysfunction
The purpose of this study is to understand the effects of kidney functional impairment may have on the study medicine (PF-07081532).
- Trial name
- NCT05510245
- Testing
- PF-07081532
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Pfizer
Type 2 Diabetes
Comprehensive Care Protocol in New Diagnosis of Type 2 Diabetes Mellitus and Associated Comorbidities in Primary Care
Introduction Type 2 Diabetes is a very prevalent chronic disease in our environment. It usually exists with other chronic diseases.
- Trial name
- PICDM2 (NCT03990857)
- Testing
- Comprehensive care protocol in new diagnosis of Type 2 Diabetes Mellitus and associated comorbidities in Primary Care
- Where
- Spain
- Volunteers
- 123 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
End Stage Renal Disease
Influence of DM on Artery Blood Flow and Complications After Radial Artery Cannulation
In atherosclerotic patients undergoing kidney transplantation, arterial cannulation is commonly performed for continuous monitoring of systemic blood pressure and intermittent assessment of arterial blood gases.
- Trial name
- NCT01897857
- Testing
- duplex Doppler ultrasonography
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Diabetes Complications, Diabetes Mellitus, Type 2
Comparison of Novo Rapid 30 Mix Injection FlexPen® and Humalog 25 Mix Injection KwikPen® in Type 2 Diabetic Patients
The purpose of this study is to investigate patient's usability, preference and blood glucose control for the new prefilled disposable insulin lispro mixture (Humalog Mix 25 injection KwikPen®).
- Trial name
- NCT00806975
- Testing
- KwikPen® and FlexPen®
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Nagaoka Red Cross Hospital
Type 2 Diabetes Mellitus
Sitagliptin/Metformin Fed Bioequivalence Study (0431A-080)
This study will demonstrate the bioequivalence of metformin after single dose administration of sitagliptin/metformin 50/500 mg fixed dose combination (FDC) tablet and concomitant administration of single doses of sitagliptin 50…
- Trial name
- NCT00929201
- Testing
- Sitagliptin phosphate/metformin hydrochloride FDC, Sitagliptin phosphate, Metformin hydrochloride
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Cystic Fibrosis
Absorption and Safety With Sustained Use of RELiZORB Evaluation (ASSURE) Study
Protocol 0000498: Multicenter, open label study to evaluate the effect of sustained RELiZORB (immobilized lipase) cartridge use during enteral feeding on fat absorption, as well as safety and tolerability of sustained RELiZORB…
- Trial name
- ASSURE (NCT02750501)
- Testing
- RELiZORB (immobilized lipase) cartridge, Impact Peptide 1.5
- Where
- 10 sites in United States
- Volunteers
- 49 people
- Sponsor
- Alcresta Therapeutics, Inc.
Type 2 Diabetes, Hypertension
Impact of Clinical Pharmacist-Led Intervention on Management of Diabetic Hypertensive Patients in Eastern Nepal
Diabetic-Hypertensives are at a higher risk of premature microvascular and macrovascular complications than diabetes alone. Proper lifestyle management, diet, disease monitoring, and medication adherence is essential in achieving…
- Trial name
- NCT05707481
- Testing
- Clinical Pharmacist-Led Educational Intervention
- Where
- Nepal
- Volunteers
- 92 people
- Sponsor
- Chettinad Academy of Research and Education (Deemed to be University)
Type 1 Diabetes
Study of Offspring of Women With Type 1 Diabetes
There is an increasing trend in the society for developing obesity, type 2 diabetes and cardiovascular diseases. It is therefore important to identify the risk factors behind this tendency.
- Trial name
- EPICOM (NCT01559181)
- Where
- 3 sites in Denmark
- Volunteers
- 584 people
- Sponsor
- Odense University Hospital
PreDiabetes
Efficacy and Safety of Digital Therapeutic in Adults With Prediabetes
The study aims to evaluate the efficacy and safety of a digital therapeutic (TH-001) for adult individuals with prediabetes.
- Trial name
- NCT05668819
- Testing
- TH-001
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Tesu Saglik Teknolojileri A.S.
PreDiabetes, Obesity, Childhood
Conventional and Metabolomic Predictors of Prediabetes & Insulin Resistance
The purpose of this study is to evaluate the longitudinal test performance of an array of conventional biomarkers of glycemia, including Hemoglobin A1c (HbA1c), and novel metabolomic biomarkers for identifying progression of…
- Trial name
- NCT05055219
- Where
- United States
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Mellitus, Hypertension
Artificial Intelligence Guided Personalised Medicine in Patients With Hypertension and Diabetes
Hypertension and diabetes are chronic diseases that require long-term management and disease control is often sub-optimal, leading to complications which place additional burden on patients and the healthcare system.
- Trial name
- NCT04769141
- Testing
- CURATE.AI
- Volunteers
- 40 people
- Sponsor
- Alexandra Hospital
Diabetes Mellitus Type 1
A Monocenter, Open-Label Glucose Clamp Study Examining the Metabolic Effect of Insulin Infusion Intervals for Basal Insulin Infusion in Patients With Type I Diabetes
This crossover, glucose-clamp study will investigate the impact of different basal insulin infusion rates on glucose control employing insulin pumps with different insulin delivery regimen.
- Trial name
- NCT00772356
- Testing
- Accu-Chek Spirit Insulin Pump, Comparator insulin pump
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Hoffmann-La Roche
Hyponatremia
Saline Infusion Test in Hyponatremia
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
- Trial name
- SITH (NCT06498856)
- Testing
- Isotonic saline infusion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Hyperglycemia, Renal Transplant Complication Primary Non-Function
Semaglutide Treatment for Hyperglycaemia After Renal Transplantation
Background: Post-transplant hyperglycaemia occurs frequently in renal transplant recipients within the first two weeks after transplantation.
- Conditions
- Hyperglycemia, Renal Transplant Complication Primary Non-Function, Diabetes
- Trial name
- Sema-RTx (NCT05702931)
- Testing
- Semaglutide 14 MG [Rybelsus]
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Type 2 Diabetes
MagDI Australia Study
The objective of the MagDI Australia Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side…
- Trial name
- NCT06473831
- Testing
- Magnet System, DI Biofragmentable
- Where
- 4 sites in Australia
- Volunteers
- 25 people
- Sponsor
- GT Metabolic Solutions, Inc.
Diabetes Type 2
Biphasic Insulin Aspart Versus NPH Plus Regular Human Insulin in Type 2 Diabetic Patients
Glycemic control is fundamental in the management of diabetes mellitus .If lifestyle intervention and full tolerated doses of one or two oral glucose lowering drugs (OGLDs) fail to achieve or sustain glycemic goals, insulin…
- Trial name
- NCT01889095
- Testing
- BIAsp 30, NPH/Reg
- Where
- Iran
- Volunteers
- 160 people
- Sponsor
- Tehran University of Medical Sciences
Obesity, Diabetes, Nutrition, Physical Health
Effects of Environmental Opportunities and Barriers on Physical Activity, Fitness, and Health in Hispanic Children in Wisconsin
This is a pilot community-based research study to examine the effects of specific environmental and social factors on physical activity, fitness, and health of middle school Hispanic children living in an inner-city community.
- Trial name
- NCT01180972
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Diabetes
Building a Behavioural Intervention Programme to Improve Self-Management of Diabetes
Effective control of diabetes requires patients to change their daily behaviour. The investigators propose an intervention programme for behavioural change with two components, targeting motivation and implementation.
- Trial name
- NCT05203575
- Testing
- Fast-forwarding in Cycle 1, Goal-Setting plus Weekly Nudge in Cycle 1, Fast-forwarding in Cycle 2
- Where
- Singapore
- Volunteers
- 225 people
- Sponsor
- National University of Singapore
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