Clinical trials: Endodontic Treatment
Teeth with Root Canal Treatment
Evaluation of the Difficulty Levels of Restorative Procedures of Endodontic Treated Teeth
The goal of this observational study is to evaluate the difficulty levels of restorations of endodontically treated teeth. The main question it aims to answer is: Does the 8 predetermined criteria effect the difficulty levels of…
- Trial name
- NCT06871319
- Testing
- periapical x-ray, orthopantomography
- Where
- Turkey (Türkiye)
- Volunteers
- 654 people
- Sponsor
- TC Erciyes University
Rheumatoid Arthritis AND Apical Periodontitis
Effect of Endodontic Treatment on Inflammatory Markers, Disease Activity and Periapical Healing in Rheumatoid Arthritis Patients With Apical Periodontitis : A Prospective Interventional Study
SUMMARY TITLE: "Effect of endodontic treatment on inflammatory markers, disease activity and periapical healing in rheumatoid arthritis patients with apical periodontitis" RATIONALE: Chronic inflammation plays a pivotal role in…
- Trial name
- NCT06433232
- Testing
- ROOT CANAL TREATMENT
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Post Operative Pain
Effectiveness of Cryotherapy on Endodontic Pain
This is a randomized , prospective , control trial to assess the effectiveness of intracanal cryotherapy on post operative pain after root canal treatment in patients with symptomatic apical periodontitis
- Trial name
- Cy (NCT06785753)
- Testing
- Irrigation Solution
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Dental Pulp Necroses, Apical Periodontitis
Effects of Intracanal Cryotherapy on Endodontic Postoperative Pain
The goal of this clinical trial is to evaluate the effect of cold saline (2.5 degrees Celsius) irrigation on postoperative pain in patients who require root canal treatment in molar teeth because of dead dental pulp and infection…
- Conditions
- Dental Pulp Necroses, Apical Periodontitis, Post Operative Pain
- Trial name
- NCT05611736
- Testing
- cold saline, saline
- Where
- Saudi Arabia
- Volunteers
- 302 people
- Sponsor
- Qassim University
Irriversible Pulpitis
Analyzing the Impact of Occlusal Reduction on the Pain Following Root Canal Therapy in Molar Teeth With and Without Pain in Turkish Patients.
Introduction: This study aimed to compare the intensity of postoperative pain after single-visit root canal treatment of symptomatic or asymptomatic teeth following occlusal reduction.
- Trial name
- NCT06953856
- Testing
- occlusal reduction
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Pulpectomy Agents
Endodontic Treatment Using CTZ Paste in Primary Teeth
The aim of this study is to evaluate the efficacy of CTZ Paste in primary teeth, compared to endodontic treatment with Guedes-Pinto Paste.
- Trial name
- SLM2204 (NCT03731975)
- Testing
- CTZ Paste, GP Paste
- Where
- Brazil
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Endodontic Treatment of Primary Teeth
Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial
The maintenance of primary teeth until their exfoliation has been one of the main purposes of Pediatric Dentistry, are they representing the fundamental basis for proper occlusion of the permanent dentition.
- Trial name
- NCT02216942
- Testing
- Endodontic treatment using Vitapex, Endodontic treatment using Guedes Pinto
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Fausto Medeiros Mendes
Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment
Application of Advanced Platelet-Rich Fibrin Plus (A-PRF+) in Revascularisation of Necrotic Immature Permanent Teeth
The goal of this clinical trial is to evaluate the effectiveness of an advanced platelet-rich fibrin plus (A-PRF+) revascularization procedure to promote healing and root development in necrotic immature permanent single-rooted…
- Conditions
- Necrotic Immature Permanent Teeth, Regenerative Endodontic Treatment, Pulp Regeneration, Root Maturation
- Trial name
- A-PRF+ (NCT07092488)
- Testing
- Advanced Platelet-Rich Fibrin Plus (A-PRF+) Revascularization Procedure
- Where
- Croatia
- Volunteers
- 28 people
- Sponsor
- University of Zagreb
Apical Periodontitis, Coronary Artery Disease
hsCRP & CH Indices in Patients With Coronary Artery Disease With and Without Apical Periodontitis
Endodontic treatment is done in Patients with chronic pulp exposure in patients with Coronary Artery Disease and systemic inflammatory markers recorded before and and after treatment and compared with patients with Coronary…
- Trial name
- NCT06270693
- Testing
- Endodontic treatment
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Post-operative Pain
Reduction of Post-endodontic Pain After 3 Irrigation Regime
The goal of this research was to relate the occurrence of post-endodontic pain after single-visit RCT using there irrigating regime.
- Trial name
- RPEP (NCT03559140)
- Testing
- Applied saline solution at 2.5 oC (Cryotherapy group), Applied saline solution at 8oC (Cryotherapy ), Applied saline solution at room temperature (No cryotherapy)
- Where
- Mexico
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Post-operative Pain
Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryoirrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial.
To compare the effect of cryotherapy versus ketorolac tromethamine irrigating solutions used as a final flush in single visit endodontic treatment in mandibular molars, with symptomatic irreversible pulpitis and apical…
- Trial name
- NCT04733326
- Testing
- Ketorolac Tromethamine, Cryotherapy, Saline
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
MTA, Calcium Hydroxide
Influence of Temporary Filling Material Composition on the Success Rate of Endodontic Treatments
The aim of this study is through a randomized clinical trial, double blind, splitmouth, evaluate the success rate (contamination rate, periapical lesion relapse and the presence of exudate between the treatment's sessions) of…
- Conditions
- MTA, Calcium Hydroxide, Endodontic Treatment
- Trial name
- NCT03488316
- Testing
- Carie removal, Absolute isolation, Manipulation of the temporary filling material based on Calcium Hydroxide
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- PAULO VINICIUS SOARES
Chronic Apical Periodontitis
Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis
Introduction: Pulpal necrosis may lead to spread of the infection from the pulp to involve the apex of the tooth and surrounding bone which when asymptomatic with periapical radiolucency on radiograph, is called chronic apical…
- Trial name
- NCT04336709
- Testing
- Calcipex II, Metapex
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Root Canal Infection, Pain
The Effect of Solvent Usage on Post-treatment Pain
No clinical evidence has been yet published regarding the comparison of postoperative pain after removal of the root canal fillings with or without solvent.
- Trial name
- NCT03756363
- Testing
- Non-solvent, Solvent
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Irreversible Pulpitis
Effect of Conservative Root Canal Instrumentation on the Release of Inflammatory Mediators in Root Canal Treatments
The goal of this clinical trial is to evaluate the expression of inflammatory mediators in the crevicular fluid and periodontal ligament after one-visit root canal treatment of mandibular molars of patients with asymptomatic…
- Trial name
- NCT06237985
- Testing
- ProTaper Gold file system, OneShape file system, TruNatomy file system
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Effect of Drug
Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain
This study aims to compare the pain reduction efficacy of Trypsin-Chymotrypsin and Naproxen sodium after root canal treatment in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT06562816
- Testing
- Trypsin-Chymotrypsin, Naproxen Sodium 550mg
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Apical Periodontitis
Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer
The objective of the study is to evaluate and compare, clinically and radiographically, the outcome of non surgical primary/secondary root canal treatment using a hydraulic sealer or a zinc oxide-eugenol sealer.
- Trial name
- NCT04249206
- Testing
- Root Canal Treatment
- Volunteers
- 54 people
- Sponsor
- Cittadella Universitaria
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Pain
Comparison of Post Operative Endodontic Pain in Patients With Irreversible Pulpitis Treated With and Without Dexamethasone.
Root canal procedure is a common procedure in dentistry. Acute inflammatory response in peri-radicular tissues after root canal treatment is the main cause of post op pain.
- Trial name
- NCT06432712
- Testing
- Dexamethasone 4mg
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Shoaib Rahim