Clinical trials: Endometrial Disease
Subfertility
A RCT on the Effect of Endometrial Injury on Improving Ongoing Pregnancy Rate in Subfertile Women Undergoing FET Cycles
This is a randomised controlled trial on the effect of endometrial injury in the cycle preceding the frozen-thawed embryo transfer (FET) cycles.
- Trial name
- NCT02197832
- Testing
- Endometrial biopsy, control procedure, Pipelle catheter (Pipelle de Cornier, Laboratoire C.C.D., France)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Endometrial Cancer
Practice Patterns Among Gynecologic Oncologists on Tumor Genetic Testing in Endometrial Cancer
In order to formulate strategies to improve adherence to best practice guidelines, as well as utilization of novel therapies, investigators must understand current practice patterns surrounding tumor genetic testing in…
- Trial name
- NCT05877404
- Testing
- Surveys
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Endometrial Cancer
Screening for Endometrial Abnormalities in Overweight and Obese Women
The purpose of this study is to develop an endometrial biopsy screening program for endometrial cancer and its precursor lesions in overweight and obese women.
- Trial name
- NCT01922778
- Testing
- Endometrial Biopsy
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Infertility, Female
Impact of Endometrial Compaction in Euploid Frozen Embryo Transfers
The purpose of this pilot study is to evaluate whether a decrease in endometrial thickness (compaction) prior to progesterone exposure (endogenous or exogenous) to the day before a single frozen embryo transfer has an impact on…
- Trial name
- NCT04330066
- Testing
- Abdominal ultrasound measurement of the endometrial lining
- Where
- United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Boston IVF
Breast Cancer, Endometrial Cancer
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
This is a Phase 1/2, open-label, multicenter study evaluating the safety, tolerability, pharmacokinetics, pharmacodynamics and anti-tumor activity of TER-2013 in patients with advanced solid tumors harboring AKT/PI3K/PTEN pathway…
- Conditions
- Breast Cancer, Endometrial Cancer, Ovarian Cancer, Lung Squamous Cell Carcinoma
- Trial name
- NCT07109726
- Testing
- TER-2013, Fulvestrant injection
- Where
- 25 sites in United States, Ireland and 3 more
- Volunteers
- 248 people
- Sponsor
- Terremoto Biosciences Inc.
Cancer Survivor, Endometrial Carcinoma
Health and Recovery Program in Increasing Physical Activity Level in Stage IA-IIIA Endometrial Cancer Survivors
This randomized phase II trial studies how well a health and recovery program works in increasing physical activity level in stage IA-IIIA endometrial cancer survivors.
- Conditions
- Cancer Survivor, Endometrial Carcinoma, Stage I Uterine Corpus Cancer AJCC v7, Stage IA Uterine Corpus Cancer AJCC v7
- Trial name
- NCT03367923
- Testing
- Communication Intervention, Counseling, Fitbit tracker
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Stanford University
Ovarian Cancer, Fallopian Tube Cancer
HS-20089 in Patients With Ovarian Cancer and Endometrial Cancer
HS-20089 is an investigational antibody-drug conjugate (ADC) composed of a humanized IgG1 anti-B7-H4 monoclonal antibody conjugated to the topoisomerase I inhibitor payload via a protease-cleavable linker, with an average…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer
- Trial name
- NCT06014190
- Testing
- HS-20089
- Where
- 28 sites in China
- Volunteers
- 460 people
- Sponsor
- Hansoh BioMedical R&D Company
Advanced Relapsed or Refractory Germ Cell Tumours, Advanced Relapsed or Refractory Endometrial Cancer
A Study to Test How Well Different Doses of BI 3820768 Are Tolerated by People With Advanced Cancer (Solid Tumours)
This study is open to adults with advanced germ cell tumours, endometrial cancer, or ovarian cancer whose previous treatments were not successful.
- Conditions
- Advanced Relapsed or Refractory Germ Cell Tumours, Advanced Relapsed or Refractory Endometrial Cancer, Advanced Relapsed or Refractory Ovarian Cancer
- Trial name
- NCT07306559
- Testing
- BI 3820768
- Where
- 13 sites in United States, Belgium and 4 more
- Volunteers
- 187 people
- Sponsor
- Boehringer Ingelheim
Endometrial Cancer
TREC Lifestyle Beyond Cancer Study in Endometrial Cancer Survivors
This randomized, controlled study evaluates the efficacy of weigh loss interventions in endometrial cancer survivors, using novel technology-based weight loss platforms.
- Trial name
- NCT02466061
- Testing
- Telemedicine Weight Management plus Wi-Fi Scale (Arm A), Text for Diet (Text4Diet) Group (Arm B), Enhanced Usual Care Group (Arm C)
- Where
- 3 sites in United States
- Volunteers
- 207 people
- Sponsor
- Fred Hutchinson Cancer Center
Uterine Cancer
Prognostic Role of molEcular classiFication in Fertility-sparing treAtment of Endometrial canCEr
Endometrial cancer, the most common gynecologic malignancy in high-income countries, is increasing among reproductive-age women.
- Trial name
- PREFACE (NCT06799624)
- Testing
- Observation only
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Ovarian Cancer, Breast Cancer
A Follow-up Study of Women Evaluated and Treated for Infertility
To assess the relations of infertility causes and treatment to cancer risk, we will conduct a retrospective cohort study of approximately 12,000 women evaluated for infertility between 1965-1988.
- Conditions
- Ovarian Cancer, Breast Cancer, Endometrial Cancer, Thyroid Cancer
- Trial name
- NCT00342446
- Where
- United States
- Volunteers
- 12,193 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Carcinoma, Prostate Carcinoma
Screening and Staging of Benign vs Malignant Pelvic Abnormalities
This study evaluates whether newly developed non-FDA approved image processing techniques [Adaptive Image Reconstruction (AIR Recon) Deep Learning (DL) and Sonic DL] can provide improved quality and decreased time compared to…
- Trial name
- NCT07407959
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cancer of Ovary, Endometrium Cancer
The Effect of Logotherapy on Mental Health in Gynecological Cancer Patients
Gynecological cancers negatively affect women's sexuality, fertility, body image, and self-perception, resulting in deterioration in their psychological health.
- Conditions
- Cancer of Ovary, Endometrium Cancer, Cervix Cancer
- Trial name
- NCT05246462
- Testing
- Logotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Endometrial Cancer, Lymphadenectomy
Comparison of Transvaginal Paracervical and Transperitoneal Approaches in Lymphadenectomy During v-NOTES Surgery for Patients Diagnosed With Endometrial Cancer
The aim of this study is to compare two types of lymphadenectomy (transperitoneal vs. paracervical) during the lymphadenectomy phase of endometrial cancer staging surgery performed using V-NOTES, a new and advanced technique.
- Conditions
- Endometrial Cancer, Lymphadenectomy, Sentinel Lymph Node Biopsy, Minimally Invasive Surgical Procedures
- Trial name
- ENDONOTE (NCT06870903)
- Testing
- Extraperitoneal(transvaginal paracervical sentinel lymphadenectomy) group lymphadenectomy, Transperitoneal lymphadenectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Endometrial Cancer
Application of da Vinci SP for Endometrial Cancer Surgical Staging
Prospective Multicenter Observational Study The study involves the consecutive inclusion of every patient with endometrial cancer undergoing staging surgical treatment using a robotic approach with the da Vinci SP platform.
- Trial name
- NCT07027046
- Testing
- Robotic surgical staging
- Where
- 3 sites in Italy
- Volunteers
- 564 people
- Sponsor
- National Cancer Institute, Naples
Endometrial Cancer
Anti-PD-1 Antibody Combined With Anlotinib in the Treatment of Endometrial Cancer
The purpose of the study is to evaluate the Efficacy and safety of Anti-PD-1 antibody combined With anlotinib in the treatment of recurrent or advanced endometrial cancer.
- Trial name
- NCT04157491
- Testing
- anlotinib and anti PD-1 antibody
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Sun Yat-sen University
Endometrial Receptivity Diagnosis
Quantitative Identification of Implantation Receptivity by Single Cell Transcriptome Analysis
This project aims to study the endometrial transcriptome at the single cell level in both endometrial native tissue (biopsies) and endometrial fluid.
- Trial name
- NCT03091023
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Igenomix
Endometrial Cancer
Prospective, Observational Study of Low-risk Criteria for Node Metastasis in Endometrial Cancer
The purpose of this study is to evaluate the efficacy of low risk criteria for lymph node metastasis, that was determined by KGOG-2014 retrospective study, in women with endometrial cancer.
- Trial name
- PALME (NCT01527396)
- Where
- South Korea
- Volunteers
- 529 people
- Sponsor
- National Cancer Center, Korea
Endometrial Carcinoma, Endometrial High Grade Endometrioid Adenocarcinoma
Molecular and ctDNA Characterization of High-Risk Endometrial Cancer
This study seeks to better understand the recurrence of high-risk endometrial cancer. It will collect information about cancer genetics to find out various hereditary or cancer specific genetic variants that may have a role in…
- Conditions
- Endometrial Carcinoma, Endometrial High Grade Endometrioid Adenocarcinoma, Stage II Endometrial Cancer, Stage III Endometrial Cancer
- Trial name
- NCT07062016
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Endometrial Cancer
Combination Chemotherapy With Nintedanib / Placebo in Endometrial Cancer
This study will evaluate the role of addition of an anti-angiogenic agent (Nintedanib/placebo) to conventional combination chemotherapy as concomitant and maintenance treatment in primary advanced or with first relapse of…
- Trial name
- NCT02730416
- Where
- 37 sites in Belgium, Denmark and 5 more
- Volunteers
- 146 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
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