Clinical trials: Endometriosis Related Pain
Endometriosis Related Pain
SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to determine the benefit and safety of relugolix 40 milligrams (mg) once daily, co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) compared with placebo for 24 weeks, on…
- Trial name
- NCT03204331
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 91 sites in United States, Australia and 9 more
- Volunteers
- 623 people
- Sponsor
- Myovant Sciences GmbH
Endometriosis, Endometriosis Ovary
Menstrual Blood Proteomic Profile in Women With Endometriosis (PROTEO-ENDO) Study
In this prospective case control study a total of 66 women (33 women with endometriosis) and (33 healthy women) will be recruited.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis-related Pain
- Trial name
- PROTEO-ENDO (NCT06214260)
- Testing
- Peripheral blood sample, Menstrual Blood sample
- Where
- Hong Kong
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Endometriosis
A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis
The main objective of the trial is to evaluate the efficacy of vipoglanstat on endometriosis-related non-menstrual pelvic pain (NMPP).
- Trial name
- NOVA (NCT07260669)
- Testing
- Vipoglanstat
- Where
- 44 sites in Bulgaria, Czechia and 5 more
- Volunteers
- 213 people
- Sponsor
- Gesynta Pharma AB
Endometriosis Related Pain, Quality of Life
Bowel ENDOmetriosis; Evaluation of Diagnostics and Quality of Life
Endometriosis on the bowel is a benign condition that can cause major complaints and severely affect the quality of life of women of fertile age.
- Conditions
- Endometriosis Related Pain, Quality of Life, Pain, Chronic, Bowel Dysfunction
- Trial name
- ENDO (NCT03779256)
- Testing
- 2D transvaginal ultrasound
- Where
- 3 sites in Australia, Austria and 1 more
- Volunteers
- 207 people
- Sponsor
- Oslo University Hospital
Endometriosis, Chronic Pain
Endocare for Pelvic-perineal Pain Related to Endometriosis Used at Home
Women with endometriosis experience recurrent pelvic-perineal pain impairing the quality of life, among other things. Endometriosis-related pain negatively impacts the sexual, family and work life.
- Conditions
- Endometriosis, Chronic Pain, Pelvic Pain
- Trial name
- NCT05172492
- Testing
- Endocare, Digital control
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Lucine
Endometriosis-related Pain
The HEROES Trial: Hyperbaric Oxygen Therapy for Endometriosis-Related Pain
Endometriosis, is a condition where tissue from the uterus, called endometrium, grows outside of the uterus. This effects up to 10% of women, and can lead to long-lasting, moderate to severe pelvic pain, infertility and other…
- Trial name
- HEROES (NCT06579040)
- Testing
- Monoplace Hyperbaric Chamber (Class III medical device)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Sunnybrook Health Sciences Centre
Endometriosis, Physical Inactivity
Chronic Pelvic Pain in Endometriosis
Endometriosis is a chronic, inflammatory disease affecting 10% (1 out of 10) of women of reproductive age. Pelvic pain is common among women with endometriosis.
- Conditions
- Endometriosis, Physical Inactivity, Chronic Pelvic Pain Syndrome, Quality of Life
- Trial name
- NCT05863663
- Testing
- questionnaire
- Where
- Hungary
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Endometriosis Thoracic, Endometriosis of Lung
Thoracic Endometriosis: A Cohort Study
Endometriosis is defined as the presence of endometrial glands and stroma outside the uterine cavity. It is an estrogen-dependent chronic inflammatory disease.
- Conditions
- Endometriosis Thoracic, Endometriosis of Lung, Endometriosis of Pleura, Endometriosis-related Pain
- Trial name
- TORENDO (NCT05527002)
- Testing
- Satisfaction of patients after medical and surgical treatment for thoracic endometriosis
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Endometriosis, Endometriosis Fertility
Evaluation of miRNAs in Endometriosis
We therefore propose a research project based on the prospective evaluation of miRNAs (blood and salivary) in patients with endometriosis diagnosed (by clinical examination and imaging) or suspected of endometriosis…
- Conditions
- Endometriosis, Endometriosis Fertility, Endometriosis-related Pain
- Trial name
- ENDOmiARN (NCT04728152)
- Testing
- Blood and salivar test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Groupe expert en endometriose-6 centre expert en endometriose
Endometriosis, Pelvic Pain
tDCS Versus tsDCS for Endometriosis-related Chronic Pelvic Pain Treatment
The purpose of the study is to compare the analgesic effect of 2 mA anodal direct current stimulation on the right primary motor cortex (M1) (tDCS) with a similar stimulation on the spine (D10) (tsDCS) in healthy volunteers (HV)…
- Conditions
- Endometriosis, Pelvic Pain, Transcranial Direct Current Stimulation, Spinal Cord Stimulation
- Trial name
- DCSErCPP (NCT02958423)
- Testing
- Transcranial DCS Healthy Volunteers, Transspinal DCS Healthy Volunteers, Transcranial DCS CPP patients
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jean Schoenen
Endometriosis-related Pain, Dyspareunia Deep
Pathways for Patient-centered Diagnosis and Management of Endometriosis-associated Deep Dyspareunia
The purpose of this study is to evaluate the acceptability and effectiveness of two tools that may help address the management of deep dyspareunia: 1) A phallus length reducer (PLR, brand name: Ohnut), consisting of 4…
- Trial name
- NCT04370444
- Testing
- Phallus Length Reducer, Self-assessment of dyspareunia
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- BC Women's Hospital & Health Centre
Endometriosis, Endometriosis-related Pain
Impact on Quality of Life of "Endo-App" (ELEA)
monocentric randomized controlled trial enrolment of endometriosis patients from certified endometriosis centers. Randomization to control group (no Endo App use) vs intervention group (Endo App use) 12 weeks use / no use of Endo…
- Conditions
- Endometriosis, Endometriosis-related Pain, Quality of Life
- Trial name
- ELEA (NCT04883073)
- Testing
- Use of Endo App
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Endometriosis, Endometriosis, Rectum
Patient Reported Outcomes After Surgery for Rectal Endometriosis
To describe the difference in patient reported outcomes after conservative treatment in comparison to radical rectal surgery in patients with deep endometriosis infiltrating the rectum (up to 15cm from the anus with at least…
- Conditions
- Endometriosis, Endometriosis, Rectum, Endometriosis-related Pain, Endometriosis; Bowel
- Trial name
- PROCURE (NCT04204707)
- Testing
- PROMS
- Where
- 2 sites in Belgium, Hungary
- Volunteers
- 294 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis Related Pain, Overactive Bladder
Study on the Safety of BAY1817080, How it is Tolerated and the Way the Body Absorbs, Distributes and Gets Rid of the Study Drug in Participants With Impaired Liver Function or Normal Liver Function
BAY1817080 is currently under clinical development to treat pain related to unexplained chronic cough or chronic cough not affected by a treatment (refractory and/or unexplained chronic cough, RUCC), or a condition where the…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04454424
- Testing
- BAY1817080, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Bayer
Endometriosis, Endometriosis-related Pain
The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.
- Trial name
- NCT04554693
- Testing
- Metronidazole Oral
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Endometriosis, Pelvic Pain
Cannabidiol for the Treatment of Pelvic Pain in Endometriosis (DREAMLAND)
The objective of this work is to conduct a randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of cannabis extract in women with endometriosis who have already undergone hormonal…
- Trial name
- DREAMLAND (NCT05670353)
- Testing
- Cannabis Derivatives, Hormonal Contraceptive Agents
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Endometriosis
Postoperative Desogestrel for Endometriosis Related Pain
Endometriosis is one of the most common disease in reproductive aged women.Surgical intervention has a significant symptoms relief. However, symptom recurrence is often after surgery.
- Trial name
- NCT01559480
- Testing
- Desogestrel
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Endometriosis Related Pain, Overactive Bladder
A Trial to Learn How a New Liquid Form of BAY1817080 is Tolerated and Taken up by the Body of Healthy Male Participants (Part A). By Labeling BAY1817080 With a Radioactive Substance (Carbon 14) Researchers Want to Learn How the Study Drug is Processed and Excreted by the Body After Dosing (Part B)
Researchers are looking for a new way to treat people suffering either from a condition where the bladder is unable to hold urine normally (overactive bladder), or a condition in which tissue similar to the tissue that normally…
- Conditions
- Endometriosis Related Pain, Overactive Bladder, Diabetic Neuropathic Pain, Refractory or Unexplained Chronic Cough
- Trial name
- NCT04487431
- Testing
- BAY1817080, [14C]BAY1817080
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer
Endometriosis-related Pain, Endometriosis
Enriched Environments in Endometriosis
The investigators propose to conduct a randomized behavioral trial that will produce a clinically useful multi-level integrative medicine model to be used in stress- and inflammation-related disorders that can easily be…
- Conditions
- Endometriosis-related Pain, Endometriosis, Pelvic Pain, Quality of Life
- Trial name
- NCT04179149
- Testing
- Environmental enrichment
- Where
- Puerto Rico
- Volunteers
- 56 people
- Sponsor
- Ponce Medical School Foundation, Inc.
Endometriosis, Endometriosis-related Pain
Rimegepant For Endometriosis Pain
The purpose of this study is to evaluate the efficacy of rimegepant 75 mg versus placebo in reducing endometriosis-associated pain (EAP) in women with moderate-to-severe pain and histologically confirmed endometriosis.
- Trial name
- NCT07795125
- Testing
- Rimegepant 75 MG
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Mayo Clinic